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Biomedical subjects

M Hatala

Publications and source records attributed to M Hatala.

At least 73 records · Page 4Linked to original sources
PubMed1977

Daily single-dose gentamicin therapy in experimental pyelonephritis.

The therapeutic efficacy of gentamicin given once or three times a day was compared in a model of experimental renal infection in rats. The same amount of gentamicin given either in a single injection or three injections a day produced no statistically significant difference in the treatment of incipient infection. The effect of this mode of administration on advanced infection depended on the length of the therapy. After five days, administration of the same dose given in a single injection or three injections did not result in significant differences. After ten days the therapy proved more effective when gentamicin was injected three times a day. In comparison a single daily dose, amounting to two thirds of the total dose when given three times a day every eight hours, revealed after five days of therapy a statistically significantly lower bacterial count in the kidney than three daily injections of gentamicin.

Animals↗
PubMed1977

Miconazole in systemic candidosis.

Results are reported on the effect of miconazole together with concurrent medication in the treatment of 7 patients with systemic candidiasis. Two patients were discharged from hospital in good condition. In two others, the clinical status normalized. One patient's status improved but he was subsequently readmitted. Two patients died. The excellent tolerance of miconazole by all patients was a particular feature of this trial.

Adult↗
PubMed1977

[Ourexperiences with clinical methods for localization of urinary tract infections].

On 35 patients with chronical relapsing urinary tact infections with different forms of the clinical course 3 localisation methods for the differentiation of infections of the upper and lower urinary tract, respectively, were evaluated. The results have shown that the bladder washout method was more reliable than the new kidney washout method. The latter method has, however, certain advantages, such as its simplicity and the catheterless accomplishment. The simplest method is the immunofluorescence investigation of the urinary sediment on the germs coated with antibodies. This method, however, still contains several unclear sources of error.

Adult↗
PubMed1976

Pharmacokinetics of tobramycin in rats with reduced renal parenchyma and in experimental shock.

Ten days after four-fifths nephrectomy in rats (four-fifths of the renal parenchyma removed), the total and renal elimination constants of tobramycin were lowered by one-half. The biological half-life of tobramycin doubled. These results suggest that soon after nephrectomy the residual nephrons are able to increase the rate of excretion of tobramycin. The increase in mass of the remaining renal tissue between day 10 and day 80 after nephrectomy had no effect on the biological half-life, on the total and renal elimination constants, and on the renal clearance of tobramycin. During endotoxin shock and burn shock, concentrations of tobramycin in serum decreased at a slower rate. The highest serum concentrations of tobramycin were observed in rats with shock due to burns.

Animals↗
PubMed1976

The influence of water diuresis on the course of experimental E. coli bacteriuria after unilateral nephrectomy in rats.

In rats of both sexes with experimental E. coli infection of the urinary bladder, we evaluated by quantitative bacteriology urinary and kidney tissue infection during low diuresis, during hydropenia, and during water diuresis. Particular attention was given to the question of whether the hypertrophying kidney following contralateral nephrectomy has the same sensitivity to infection ascending from the bladder as a normal kidney. The results showed that water diuresis results in a long-term significant bacteriuria with penetration of microorganisms into the kidney. However, we did not find that infection of a solitary kidney following contralateral nephrectomy was of any greater degree than infection in the kidneys of rats with both kidneys intact.

Animals↗
PubMed1975

Effects of various immunosuppressive drugs on the development of experimental renal infection in rats.

The effect of azathioprine, hydrocortisone and antihymocyte serum on the development of experimental colibacillary renal infection in rats was assessed by macroscopical findings in the kidneys, especially by determining the number of microbes in the infected organ, on day 7 after injection of the infectious agent. The greatest multiplication of bacteria and so the most pronounced macroscopical changes occurred after ALS treatment. There was statistically significant difference between ALS-treated group and the control group, whereas the differences between controls and the other experimental groups (Imuran, hydrocortisone) were non-significant.

Animals↗