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Biomedical subjects

M Hata

Publications and source records attributed to M Hata.

At least 307 records · Page 17Linked to original sources
PubMed1977

Double isotope derivative dilution method for the determination of prostaglandin F and E type metabolites in urine.

This method was developed for the quantitative determination of the main ureinary metabolite (MUM) of prostaglandin (PG) F and E type in man or experimental animal. This method was based on the extraction of PG-MUM after addition of 3H-PG-MUM, the esterification with 14C-acetic anhydride and the separation and purification by column chromatography. Excretion values of adult men were PGF-MUM 1.46--15.01 microgram/8 hr (n=11), PGE-MUM 0.8*--15.42 microgram/8 hr; and with women, PGF-MUM 0.41--7.75 microgram/8 hr (n=11), PGE-MUM 0.60--11.39 microgram/8 hr.

Animals↗
PubMed1976

Transplantation of human renal cell carcinoma to the nude mice: as an intermediate of in vivo and in vitro studies.

Five human renal cell carcinomas were transplanted successfully to nude mice fed and grown under a specific pathogen-free condition. The histology of the transplanted tumor tissue was a close reproduction of the original human cancer tissue in situ. The transplanted tumor tissue possessed an abundant supply of blood vessels, which was considered to be of host animal origin. All transplanted tumor cells grew easily when transferred to an in vitro cell culture system from the nude mice. In this latter cell culture system tumor cells demonstrated a growth pattern characteristic of epithelial cells. The electron microscopy of these cells showed some characteristic morphological features that indicated their cytological origin.

Adenocarcinoma↗