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Biomedical subjects

M Hassan

Publications and source records attributed to M Hassan.

276 records · Page 16Linked to original sources
PubMedDate not supplied

Structural considerations in the metabolism of nitriles to cyanide in vivo.

In order to investigate structure-activity relationships that influence metabolism of nitriles to CN-, thiocyanate was measured, as an index of CN- release, in urine of rats given equimolar doses of nitriles. Significantly more SCN- was excreted after po than after ip administration of saturated (C2-C5) nitriles, but SCN- excretion was the same after both routes for n-hexanenitrile. Among saturated nitriles, SCN- excretion was maximal for the C3 and C4 compounds, propionitrile, n-butyronitrile, and isobutyronitrile, after both po and ip administration. SCN- excretion was not elevated after administration of the tertiary nitrile trimethylacetonitrile. Administration (po) of the unsaturated nitriles acrylonitrile, crotonitrile, and 3-butenenitrile yielded 37%, 5.6%, and 29% of the dose as SCN-, whereas after ip injection 4.5%, 4.6%, and 18% of the doses were excreted as SCN-, respectively. After iv injection of acrylonitrile, urinary SCN- content was not elevated, whereas 45% of an iv dose of the saturated analog propionitrile was excreted as SCN-. These results suggest that length of the carbon chain, presence of substituents at the alpha-carbon, position of double bonds, and, for some compounds, route of administration, are important factors influencing the release of CN- from nitriles.

Animals↗
PubMedDate not supplied

[Echography of the foot in newborn infants. Preliminary study].

Xrays are of a poor help in the diagnosis of the deformities of the foot in the neonate. As a modern imagying, ultrasounds allow to show the cartilaginous frames and also the soft-tissues. Some special views are used which can give interesting informations about the abnormal connexions of the hindfoot and also the midtarsal joint. This procedure is also used for the follow up during the treatment in order to appreciate its efficiency.

Clubfoot↗