Biomedical subjects
Publications and source records attributed to M Harms.
After a two month treatment with colchicine in small doses, a 43 year old patient suffered from a diffuse alopecia. The hairs were damaged and mostly broken 1-2 cm above the scalp. Microscopic examination with polarized light proves to be a very efficient and simple method of investigation of the hair.
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A 65-year-old male patient is described who presented with (1) large violet cutaneous plaques on the left side of the body, characterized by dense plasmocyte infiltration of the dermis which appeared benign and largely negative to immunofluorescence, (2) massive polyclonal cryoglobulinemia (type III) without paraproteins, and (3) intermittently marked peripheral monocytosis and thrombopenia without significant medullary changes. Compared with the cases reported in the literature, and after a thorough immunological investigation, this syndrome cannot be entirely assimilated to any entity described up to the present time. Hypothetically, a reactional disorder is the most likely.
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After topical application of the carcinogen DMBA on the rabbit's ear, tumors will always appear. These are clinically characterized by their important hyperkeratosis. Some of these tumors develop rapidly and disappear completely as do KA. Others do not reach such an important size but do not regress. None of these tumors looked like a malignant tumor and did not show signs of invasiveness nor metastasis. However the histological findings reveal in some cases precancerous and malignant aspects. The number of tumors can be increased by lengthening the application time of the carcinogen, by modifying the mode of application (repeated application and transport medium DMSO) and by irradiation.
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The authors observed one case of plasmocytic reticulosis which was noticable by its strictly left unilateral localisation, involving the face, the underscapular region, the shoulder and the elbow, the leg with an important augmentation of the left foot. Histologically, dense plasmocytic infiltration can be observed without anomalies. Electron microscopy confirmes the presence of plasmocytes at any stage of activity without monstruosities. This observation can not be classified in the forms that are actually described: Klüken's and Simonis' plasmocytic reticulosis, plasmocytomas with osseous and medullar lesions, extramedullar plasmocytoma.
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We report the case of a 48-year old man who after a disease-free interval of 7 years developed a relapse of pemphigus vulgaris (PV) presenting as pompholyx of the left foot. The patient was first thought to suffer from a dyshidrosic form of tinea pedis due to Trichophyton rubrum. Although the concomitant occurrence of a dermatomycosis and PV has been described previously, our case illustrates an unusual and misleading presentation of PV, which may delay the correct diagnosis.
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