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Biomedical subjects

M Harms

Publications and source records attributed to M Harms.

At least 55 records · Page 3Linked to original sources
PubMed1993

Genetic serum protein markers in eight south Indian caste and tribal populations.

A total of n = 769 unrelated male and female individuals from eight endogamous caste (Brahmin, Kapu, Yadava, Relli) and tribal (Bagatha, Kotia, Manne Dora, Konda Dora) populations living in various districts of Andhra Pradesh (India) have been typed for haptoglobin (HP) types and transferrin (TF), group specific component (GC) and alpha 1-antitrypsin (PI) subtypes. The genetic heterogeneity among these population groups is considerable. This can be explained by lacking or at least only minimal gene flow among these caste and tribal groups, by which differences in their genetic profiles caused by locally acting genetic differentiation factors such as drift could be preserved.

Alleles↗
PubMed1993

[Multiple filiform hyperkeratoses].

We report on a 41-year-old female patient who presented with a 3-year history of multiple filiform hyperkeratoses on the trunk. The family history revealed that her uncle had similar skin lesions. Another patient presented with filiform hyperkeratoses only on the palms of the hands and soles of the feet. This condition, referred to in English as multiple minute digitate hyperkeratoses, is a rare, mostly hereditary, disorder of cornification. As yet there is no official name for this dermatosis in German; we propose "multiple filiforme Hyperkeratosen".

Adult↗
PubMed1992

[Bacillary angiomatosis: apropos of a case].

We report a case of bacillary angiomatosis (BA), a recently described opportunistic infection, in a 30-year-old patient with Aids who was referred for a purplish vascular nodule on the forehead, of one-month duration, surrounded by similar smaller papules. For the previous 4 months he had suffered from progressive cachexia with fever, chills, night sweats, arthralgias and bone pain for which no infectious or malignant cause had been discovered after an extensive medical work-up. Histological examination of the skin lesions using Warthin-Starry staining revealed lobular vascular proliferation and protuberant endothelial cells with clumps of small bacilli. These findings were confirmed by electron microscopy. We believe that this is the first case of BA diagnosed in Switzerland and discuss the skin lesions, systemic symptoms and evolution under antibiotic treatment.

Acquired Immunodeficiency Syndrome↗
PubMed1992

Orbital and palpebral paraffinoma.

Paraffinoma is a well-recognized complication of paraffin injection. We describe a 44-year-old man who had an ethmoidectomy for chronic sinusitis. A communicating fracture of the ethmoid bone into the orbit occurred intraoperatively. The nasal cavity was subsequently packed with gauze containing a petrolatum-based antibiotic ointment. Bilateral, periocular swelling developed 1 week later. Optical and electron microscopic studies revealed a paraffinoma.

Administration, Intranasal↗
PubMed1992

Systemic corticosteroids do not prevent postherpetic neuralgia.

We review the use of corticosteroids in preventing postherpetic neuralgia (PHN) in a retrospective study over 5 years and 10 months. Out of 113 patients evaluable, 46 (40%) had PHN. 21 of these 46 patients (38%) had received prednisone (p = 0.49; n.s.). Duration and intensity of PHN were not different in the prednisone-treated group. This long-term study does not support the use of prednisone for preventing PHN.

Female↗
PubMed1992

Histiocytic lymphophagocytic panniculitis (Rosai-Dorfman disease): a case report.

A 68-year-old woman presented with a symmetrical enlargement of the face and submandibular area associated with essential thrombocytosis. Biopsy of the lesions revealed a septal and lobular panniculitis disclosing a lymphohistiocytic and plasma cell proliferation with lymphophagocytosis by histiocytes, compatible with Rosai-Dorfman disease. The lesions regressed spontaneously without therapy over a period of 4 months. Diagnosis was confirmed by electron-microscopic examination and immunocytochemical presence of S-100 antigen within the histiocytic cells. A 2-year follow-up did not demonstrate any evidence of recurrence.

Aged↗
PubMed1991

[The significance of protein C deficiency in dermatology].

The protein C system is a physiological inhibitor of coagulation and is important for the regulation of hemostasis. Protein C deficiencies can be inherited or acquired, and they lead to enhanced thrombophilia. A number of clinical entities that are also of interest to dermatologists have been related to protein C deficiency. Inherited protein C deficiency can become manifest in various ways, e.g. as purpura fulminans neonatalis, as recurrent episodes of thrombosis and as coumarin necrosis. Acquired protein C deficiency can be observed in the course of purpura fulminans, disseminated intravascular coagulation, hepatic failure or in the presence of antiphospholipid antibodies. The clinical features, the possible pathogenesis and the therapy of these manifestations are briefly discussed.

Humans↗
PubMed1991

[Lichen sclerosus et atrophicus].

A review of lichen sclerosus et atrophicus is presented in this article. Clinical manifestations, possible complications and histology are described. Particular emphasis is given to the aetiological hypotheses, which include genetic, autoimmune, hormonal and infectious mechanisms. Finally, the various treatments are discussed.

Adolescent↗
PubMed1990

[Hand dermatoses in children].

Dermatoses of the hand in children are part of an original entity which can be classified in two groups: a group involving exclusively the hands and another one which is predominantly involving the hands. Attention has been focussed mostly on hand dermatoses in children (acropustulosis of infancy, papular, acrodermatitis, hand foot and mouth disease, subungual, exostosis). We discuss also the diagnostic and therapeutic aspects of scabies in children.

Acrodermatitis↗
PubMed1990

Papular-purpuric "gloves and socks" syndrome.

We report five cases of an acute, self-limiting dermatosis that has not been previously described. It consists of a pruritic edema and erythema of the hands and feet in a gloves-and-socks distribution and is associated with oral lesions and fever. The clinical course is characterized by the rapid development of petechial purpura and clearing of lesions within 1 to 2 weeks. The disease appears to affect only young and otherwise healthy persons and occurs mostly during the spring. The etiology is unknown but might be of infectious origin.

Adolescent↗
PubMed1990

Silica granuloma mimicking granulomatous cheilitis.

A 45-year-old female presented with macrocheilitis of the upper lip. Histologically numerous well-demarcated granulomas were present in the dermis and hypodermis. Examination under polarized light revealed birefringent crystalline particles. The patient had suffered a road accident 25 years ago. This case illustrates the characteristic features of silica granuloma without systemic manifestations. The clinical presentation as macrocheilitis may mislead into the wrong diagnosis.

Diagnosis, Differential↗
PubMed1989

Quantitative cultures of biopsy specimens from cutaneous cellulitis.

To study the microbiologic features of cutaneous cellulitis prospectively, quantitative biopsy cultures were carried out in 25 patients who were hospitalized for an untreated cutaneous cellulitis. Biopsy specimens were obtained from both the center and the advancing edge of erythema. Only nine biopsy specimens (three central and six peripheral) (18%) of 50 yielded pathogens. Needle aspiration cultures were performed in seven cases: two yielded pathogens (28.5%). The density of microorganisms was low, ranging from less than 80 colony-forming units (CFUs) per gram of tissue to 1360 CFUs/g of tissue, except next to the edge of an ulcer (two cases), where densities reached 3.2 x 10(6) CFUs/g of tissue. Cutaneous cellulitis shows a discrepancy between the low density of microorganisms and the intensity of the inflammation. A factor other than infection must be implicated. This might be lymphatic failure, which is found in 72% of patients.

Bacteriological Techniques↗