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Biomedical subjects

M Hansmann

Publications and source records attributed to M Hansmann.

At least 145 records · Page 8Linked to original sources

Fetal weight estimation by real-time ultrasound measurement of biparietal and transverse trunk diameter.

Measurements of biparietal diameter and transverse trunk diameter with the use of linear array real-time B-mode scanning were performed on 100 fetuses within 72 hours of delivery to evaluate the reliability of Hansmann and associates, nomogram in predicting fetal weight. Under optimal conditions, 82% of predicted birth weights were within 10% of actual birth weight with a mean error of 150 gm (6%) and a correlation coefficient of 0.98. Predictions were most accurate in fetuses weighing less than 1,500 gm and in the 2,000 to 4,000 gm group and were least accurate in the infant weighing less than 1,500 gm and in the 2,000 to 4,000 gm group and were least accurate in the infant weighing more than 4,000 gm. Once the accuracy of the method was determined, It was applied to 100 consecutive cases to evaluate the feasibility of this technique in clinical practice. Measurements were unobtainable in 15%, but in the remainder, predictions were of sufficient accuracy throughout the range of fetal weights to complement clinical assessment in the management of high-risk pregnancies. Seventy-four percent of predicted weights were within 10% of actual birth weight; the mean error was 165 gm (7.2%) and the correlation coefficient was 0.97.

Birth Weight↗

[Cytogenetic, gynaecological and sonographic aspects of twin pregnancy with parental Robertsonian translocation 13/14 (author's transl)].

A prenatal chromosome analysis for a parental Robertsonian translocation 13/14 is absolutely imperative. In the present case of a twin pregnancy, it was possible to present the chromosome complement of only one foetus. Since this foetus showed the Robertsonian translocation in the same form as the phenotypically healthy mother, and since the ultrasound findings were normal, it was concluded that foetus I was normal. Further measures for the cytogenetic analysis of foetus II were abandoned after the first amniotic sample could not be analysed. At the time of the amniocentesis this child was retarded when compared to foetus I. Since the life expectancy of a possibly chromosomally unbalanced child is slight, it was not necessary for the parents to take further steps. During the rest of the pregnancy however, this difference in the development of the children evened out unexpectedly and two phenotypically healthy children were born. The implications of a delayed growth rate as an indication of abnormal foetal development are discussed.

Adult↗

Pregnancies following chronic intermittent (pulsatile) administration of Gn-RH by means of a portable pump ("Zyklomat")--a new approach to the treatment of infertility in hypothalamic amenorrhea.

In previous studies it could be demonstrated that in severe hypothalamic amenorrhea, which is associated with absent or deficient hypothalamic secretion of Gn-RH, ovarian function could be restored by chronic intermittent (pulsatile) administration of Gn-RH. In order to apply chronic intermittent administration of Gn-RH as a new mode of treatment of infertility in hypothalamic amenorrhea on an outpatient basis a portable device ("Zyklomat") was constructed consisting of a peristaltic pump, a computerized timing device and a Gn-RH containing bag, which delivers 50 microliters of a Gn-RH containing solution once every 90 minutes via an i.v. catheter into the circulation. It is the purpose of this communication to present this new method of treatment and the successful induction of the first two pregnancies with this method in two patients with severe hypothalamic amenorrhea.

Adult↗

Renin activity and concentrations of angiotensin I and II in amniotic fluid of normal and Rh-sensitized pregnancies.

Renin activity and the concentrations of angiotensin I and angiotensin II in amniotic fluid of second- and third-trimester pregnancies were determined by radioimmunoassay. Between the 28th and 38th wk of gestation, the mean renin activity in the amniotic fluid was higher than during early pregnancy (before the 18th wk of gestation). Both renin activity and the concentrations of angiotensin I and II were increased on some cases of Rh-incompatibility. One to two weeks after the administration of betamethasone to the mother with threatened premature delivery, the intra-amniotic renin--angiotensin system was slightly suppressed. In urine samples of newborns, angiotensin concentrations were in the same range as those found in the amniotic fluid; renin activity was very low or undetectable in the urine of male neonates (1--7 days of age). Thus, angiotensin II in the amniotic fluid may be derived both from fetal urine and/or as the product of enzymatic reactions in the amniotic sac; the latter is dependent not only on the presence of renin and converting enzyme but also on the local renin substrate (angiotensinogen) concentration.

Adult↗

[Ultrasonic biometry of the fetal crown-rump length between 7 and 20 weeks gestation (author's transl)].

In 370 examinations on 258 patients with known gestational age crown-rump length (CRL) of the fetus was determined by sonar between 7 and 20 weeks. From the results the mean and "2 SD" limits of CRL were derived by means of a non linear regression analysis. The measurements were further analysed to determine gestational age for a given CRL. Besides a velocity curve of CRL growth was calculated. It showed a maximum of 1.8 mm per day at 14 weeks. It was confirmated that sonar measurements of crown-rump length are very useful to estimate maturity of the fetus. The accuracy was found to be best in early measurements (+/-6 days at 7 weeks -+/-11 days at 20 weeks). In regard to clinical decisions reading errors have to be taken into consideration. To avoid them control examinations should be carried out.

Anthropometry↗

Sex determination in nuclei of amnion fluid cells.

Hypotonic treatment of amnion fluid cell-nuclei was found to enhance demonstration of Y chromatin and of autosomal fluorescence in interphase cell-nuclei following quinacrine mustard staining. In contrast, visualization of the Barr body was not improved by this treatment. Nuclear sex determination on cellular material from 200 samples of amniotic fluid was unequivocal in 197 cases; in only 3 cases were the findings uncertain. There were no erroneous determinations. In one instance maternal cellular tissue was observed in smear preparations. Nuclear sex determination presents a simple method of supplementing and substantiating prenatal chromosomal diagnosis.

Amniocentesis↗

[Clinical aspects and diagnosis of intrauterine growth retardation].

Low birthweight infants add to a great extent to perinatal mortality. Among this group children with intrauterine growth retardation differ from premature children with respect to their pre-, intra- and postnatal risk. Early prenatal diagnosis and monitoring is of great importance for the outcome and later development of these children.

Adult↗

[A mobile reanimation model (reanimationmobile) for initial newborn infant care].

A mobile unit for reanimation of the newborn is reported to be used alternatively in the deliveryroom or in the surgical tract. The following adventages are achieved: a large working plate easily accessible from three sides, a complete and variable instrumentation, an efficent warmth supply and the possibility for easy cleaning and desinfection.

Disinfection↗

[Topography of a reference plane for ultrasonic thoracometry (author's transl)].

A method of ultrasonic thoracometry is reported which uses the veins of the fetal liver as landmarks. The fact that the umbilical vein running from the anterior abdominal wall to the "sinus venae portae" is visible in B-scan display is the given presupposition. In a study about topography of the vein system of the fetal liver in 50 cases the description of a so called "sinus-plane" for sonar thoracometry is given. This reference plane is shown to be identical with the "lower apertura of the fetal thorax" recommended by Hansmann and co-workers since 1971. Thereby the nowadays well established method of thoracometry in obstetrical routine work gets a more accurate definition in regard to it's topography. This is not only of theoretical interest but will improve the conditions for more accuracy and reproducibility of the method.

Anthropometry↗