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Biomedical subjects

M Hansen

Publications and source records attributed to M Hansen.

At least 325 records · Page 18Linked to original sources
PubMed1985

A broncho-biliary fistula probably due to exacerbation of chronic pancreatitis. A short review of the literature.

Broncho-biliary fistulae are generally secondary to echinococcal abscesses in the liver, less frequently to trauma, penetrating or not. A third group seems to follow biliary tract obstruction, surgical or non surgical. Congenital broncho-biliary fistulae seem to be extremely rare. We present here a case of broncho-biliary fistula probably secondary to an exacerbation of chronic pancreatitis. Liberal surgical drainage, safe closure of the diaphragm and early surgical intervention are mandatory and are emphasized.

Biliary Fistula↗
PubMed1984

Phase II trial of epirubicin in advanced squamous, adeno- and large cell carcinoma of the lung.

Epirubicin , a stereoisomer of doxorubicin with suggested lower potential for cardiotoxicity in animal tumor systems, was evaluated in a disease-oriented phase II trial in non-small cell lung cancer. The drug was given as a direct i.v. injection of 90 mg/m2 repeated every 3 weeks. Four partial remissions were observed among 75 evaluable patients. Forty-two of the 75 patients had received no prior chemotherapy. The predicted true response rate is equal to 5% (0.2-10%). Leucopenia (75% of patients), gastrointestinal disturbances (76% of patients) and alopecia (53% of patients) were common side-effects observed. Four patients had cardiac abnormalities after treatment with epirubicin (one sinustachycardia , two premature beats, one biopsy-proven cardiomyopathy with congestive heart failure). One patient developed a peripheral neuropathy possibly related to epirubicin . We conclude that epirubicin in the present dose and schedule is an inactive agent in patients with non-small cell lung cancer.

Adenocarcinoma↗
PubMed1984

Acute interstitial pneumonitis caused by Aleutian disease virus in mink kits.

In four Danish mink ranches acute interstitial pneumonitis caused excessive mortality among kits within the first 2 1/2 months after parturition. The disease was found to be due to an Aleutian disease virus (ADV) and could be reproduced experimentally in neonatal kits by inoculation with material from spontaneous cases, as well as with other strains of ADV. Experimental reproduction was only possible in kits from dams free of Aleutian disease (AD) whereas kits from dams experimentally or naturally infected with ADV developed no lung changes. Presently available evidence indicates that the initial lung lesions result from primary viral injury to type II alveolar cells, and that immune mechanisms, essential for the development of traditional AD, are not involved in the pathogenesis.

Aleutian Mink Disease↗
PubMed1983

Cefotaxime versus ampicillin, methicillin and netilmicin in combination for treatment of febrile episodes in patients with haematologic malignancy.

A prospective, randomized trial comparing treatment of 61 febrile episodes with cefotaxime (CTX) versus a combination of ampicillin, methicillin, and netilmicin (AMN) was carried out in 58 patients with leukaemia or malignant lymphoma, of whom 28 had a granulocyte count of less than or equal to 500 X 10(6)/l. The overall response frequency was 63% for CTX against 49% for the AMN combination, the latter figure being lower than generally reported in the literature. The difference was not statistically significant. In 21 episodes pathogens were isolated, 16 of them from the blood. All isolated bacteria but one, a strain of Bacteroides fragilis, were fully sensitive to at least one of the three antibiotics in the combination, and all but one, a strain of Listeria monocytogenes, were fully sensitive to CTX. These results indicate that CTX seems to be a promising alternative as monotherapy for empiric treatment of febrile episodes in patients with haematologic malignancies. Further investigations will, however, be required before completely rational choices between mono and combination therapy of febrile episodes in immunosuppressed patients can be made.

Adolescent↗
PubMed1983

Electron microscopic sub-classification of small cell carcinoma of the lung.

An electron microscopic study of 28 small cell carcinomas of the lung is presented. Cytoplasmic secretory granules, characteristic of endocrine cells of the human foetal lung were observed in a variable number of tumor cells. Two groups of tumors could be distinguished based on the morphology of the cytoplasmic secretory granules. Twenty-three tumors showed cells with granules resembling type 1 or P1 cells of the human fetal lung, and 5 tumors with granules resembling type 3 cells of the human fetal lung. No relationship was found between the light microscopic WHO classification of small cell carcinoma of the lung and the results obtained by electron microscopy. Increased serum calcitonin as well as inappropriate ADH secretion may be correlated with one of the two types of small cell carcinoma, but further investigations are needed.

Adrenocorticotropic Hormone↗
PubMed1983

Demonstration of autoantibodies against ACTH in serum from a patient with cancer of unknown origin.

We report the presence of autoantibodies against ACTH in plasma from a 46 year old man with poorly differentiated adenocarcinoma of unknown origin. There was no evidence of Cushing's syndrome. By radioimmunoassay and immunocytochemical technique the antibodies were found to possess specificity against the 13-24 aminoacid sequence of ACTH. This sequence includes the biologically active site. On the basis of our findings it is discussed whether the presence of the autoantibodies could reflect a fundamental immunological disturbance primarily or secondarily related to cancer.

Adenocarcinoma↗
PubMed1983

Continuous versus alternating combination chemotherapy for advanced small cell carcinoma of the lung.

In a 2-year period, 146 patients with small cell carcinoma of the lung, staged as having extensive disease, were randomized to receive either continuous chemotherapy consisting of (a) 1-(2-chloroethyl-3-cyclohexyl-1-nitrosourea, cyclophosphamide, methotrexate, and vincristine followed by (b) 4'-demethylepipodophyllotoxin 9-[4,6-O-(R) ethylidene-beta-D-glucopyranoside] and doxorubicin at progression of disease or a regimen of (a) alternating with (b). Seventy-six patients received the continuous regimen; 70 patients received alternating treatment. Response rates were 68 and 72%, respectively. The median duration of response was 16 weeks in patients receiving continuous treatment compared to 28 weeks in patients receiving alternating treatment (p less than 0.05). No survival time difference was observed between the groups, median survival being 36 and 38 weeks, respectively. Four patients became long-term survivors (5.6 +, 5.5 +, 5.1, and 4.7 + years). All received alternating therapy. Six toxic deaths were observed among patients receiving continuous therapy compared to only one death among those in the alternating regimen. In conclusion, alternating combination chemotherapy leads to prolonged duration of remission. Duration of survival is not prolonged in uncured patients, but an increased possibility of long-term disease-free survival cannot be precluded.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1982

Incomplete differentiation of Wolffian structures: a form of Kallmann's syndrome?

We have reported a sibship in which all three males had azoospermia and a normal 46,XY karyotype. The mechanisms for the production of azoospermia were Kallmann's syndrome and bilateral agenesis of the globus major (head of the epididymis) in the proband and bilateral agenesis of the vasa deferentia and seminal vesicles in the two brothers. It is suggested that this syndrome of agenesis of the testicular excretory system may be a variant of Kallmann's syndrome.

Adult↗
PubMed1982

[Differentiation of functional knee movement in hemophilic patients by means of ultrasonic topometry (author's transl)].

First experiences using UST (Ultra-Sound-Topometry) in functional analyses of the loco motor system show: The motor patterns in gait analyses can be analyses can be visualized in such high steric- and time-resolution, that even slightest disturbances can be seen and localized. The high resolution of the procedure allows exact analyses of the movement patterns within the joints. In the knee, for example, we could demonstrate, how in slight to marked pathology the stress in the cartilagenous layers is disturbed in different ways. Out of this, conclusions, concerning the intraarticular destructions and their effects on the kibernetic chain, can be made.

Biomechanical Phenomena↗