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Biomedical subjects

M Hamza

Publications and source records attributed to M Hamza.

At least 73 records · Page 4Linked to original sources
PubMed1988

An autosomal recessive disorder with retardation of growth, mental deficiency, ptosis, pectus excavatum and camptodactyly.

Two strikingly similar brothers issued from consanguineous parents in the second degree present the following patterns of anomalies: retardation of growth, mental deficiency, ocular abnormalities, pectus excavatum and camptodactyly. The ocular abnormalities include ptosis, microphthalmia and hypertelorism. No endocrine or metabolic aberrations were found. The authors conclude that the disorder has probably an autosomal recessive mode of transmission.

Abnormalities, Multiple↗
PubMed1988

Infantile botulism.

We present the first two known cases of infantile botulism in Oklahoma. The first case was due to type B toxin; the second was due to type A toxin. Both cases demonstrate most of the classic features of what now appears to be the most common form of botulism. Infantile botulism is an underrecognized but reversible cause of hypotonia. In most cases, the prognosis is excellent with institution of appropriate supportive care. The recognition of cranial nerve palsies or a history of constipation should raise the suspicion of infantile botulism. Aminoglycoside antibiotics and other agents that may precipitate or exacerbate neuromuscular blockade should be used with extreme caution in hypotonic infants until the cause of the hypotonia is clearly identified.

Botulinum Toxins↗
PubMed1988

Parainflammatory leukoencephalomyelitis: clinical and magnetic resonance imaging findings.

Parainflammatory leukoencephalomyelitis is a broad term used to include the spectrum of disorders that affect the central nervous system following infection, immunization, or other noxious stimuli. There is a wide range of clinical and pathologic severity, ranging from acute cerebellar ataxia to acute hemorrhagic leukoencephalopathy. With the improved survival of these patients, magnetic resonance imaging provides a window to the pathologic process, which can aid in the long-term management of these patients. Although lesions of the brainstem and spinal cord correlate well to clinical symptoms, multiple cortical lesions may be present without specific localizing signs. The distribution of magnetic resonance lesions is different from that commonly seen in multiple sclerosis. In some cases, prolonged immunosuppression may be required to prevent recrudescence of the inflammatory response.

Cerebellum↗
PubMed1988

[Arterial involvement in Behçet's disease].

Ten cases of Behçet's disease with arterial lesions were observed in a series of 500 patients over a period of 12 years. The majority of patients were male (9/10) aged between 24 and 36 years with a mean of 30 +/- 5 years. The first group (3 cases) presented with thrombosis of the radial and superficial femoral arteries, the second group (4 cases) presented with aneurysm of the subclavian artery, common and external iliac arteries, brachiocephalic trunk and abdominal aorta and the third group (3 cases) had a combination of thrombosis and aneurysm of the pulmonary, external iliac and renal arteries.

Adult↗
PubMed1988

[Pathogenic concepts, nosological limits and diagnostic criteria of Behçet's disease].

Behçet's disease, a multi-system disease, raises aetiological and classification problems. Its aetiology is unknown, although several factors have been incriminated in its pathogenesis: immunogenetic, toxic, viral, hormonal,... It overlaps with several groups of diseases: seronegative spondyloarthritis, connective tissue diseases, angiitis, uveomeningitis and aphthosis. Several diagnostic criteria proposed by various authors are discussed.

Behcet Syndrome↗
PubMed1988

[Pathology and physiopathology of Behçet's disease].

The etiology of Behçet's disease, a multisystems disease, is unknown. Epidemiological, clinical and experimental data indicate that genetic factors and other environmental factors of viral or toxic origin, are necessary for the disease to develop. Sex, age of occurence, presence of familial forms, and frequency of the HLA-B5 gene form the immunogenetic support. The geographic distribution, the results of some virologic studies, and the fact that the disease may be reproduced in animals by organo-chlorinated derivatives, form the support of the environmental factor. Study of the interferon gamma system and T lymphocytes sub-populations is in favor of a viral etiology. Hormonal factors may modulate the clinical manifestations of the disease. Circulating immune complexes may be responsible for certain lesions: uveitis, arthritis, erythema nodosa, and central nervous system involvement. The lymphocytes cytotoxic activity and the increased chemotactile activity are supposed to be the physiopathological base of aphtha, papulo-pustulous skin lesions and the pathergic phenomenon.

Behcet Syndrome↗
PubMed1988

Natural killer cells in Behçet's disease.

We studied natural killer (NK) cell activity and numbers in the peripheral blood obtained from patients with Behçet's disease (BD) in inactive and convalescent stage, and from healthy controls. Ratios of helper/suppressor cells (OKT4/OKT8) were below 1.0 in patients with active stage and were normal in the convalescent stage of BD. A relative increase of OKT8+ cells and at the same time of Leu 7+ cells was obtained in the active and convalescent BD stages. Double marker analysis revealed that the sub-population of cells expressing both the T8+ and the Leu 7+ antigen (T8+/Leu 7+) was increased in patients with active stage, and normal in the convalescent stage. The frequency of cells reactive with Leu 11 monoclonal antibody (active NK cells) was evaluated in patients with BD. Data from peripheral blood showed an increased sub-population of T8+/Leu 7+ double marker cells, and a decreased Leu 11+ cell sub-population in patients with active BD, but the majority of Leu 7+ cells in patients with convalescent stage lacked OKT8 antigen when investigated in a double marker system. A parallel increase of Leu 11+ cells was observed in the convalescent stage. This phenotypic analysis was carried out with the NK in vitro functional evaluation of cell populations from peripheral blood. NK cell activity in the clinically active stage of BD was significantly lower than that of healthy controls and patients in the convalescent stage. The decrease of peripheral blood NK function in patients with active BD may be related to the presence of immature forms of NK cells and/or to the increased percentage of T8+/Leu 7+ cells.

Adult↗
PubMed1987

Uptake and binding of teniposide (VM26) in Krebs II ascites cells.

With [3H] VM26 as marker, the uptake and binding of teniposide have been made in cells of Krebs II ascitic tumors. The intracellular accumulation of drug displayed a passive diffusion and a saturation kinetics with an apparent Michaelis-Menten constant of 37.54 10(-6) M and a flux of 13.4 nM/min/mg of protein. VM26 was rapidly taken and an equilibrium was established with the extracellular drug in about 30 min. The steady-state accumulation was diminished by Na+ and Ca2+ absence and VP16-213, whereas, K+ and Mg2+ have no effect. Energy dependence of the system was characterized by a Q10 of 1.75 +/- 0.2 and the uptake was reduced by ouabain and iodoacetamide, when 2-4-dinitrophenol and glucose absence were without appreciable change. The study of the efflux showed that about 87% of the uptaken drug was removed, the residual amount being probably irreversibly bound. The intracellular accumulation of the drug was associated with various cell organelles, however, only the nuclear fraction demonstrated a high affinity binding.

Animals↗