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Biomedical subjects

M Hallberg

Publications and source records attributed to M Hallberg.

27 records · Page 2Linked to original sources

Neonatal endocarditis requiring surgery.

A case of infective endocarditis in a neonate is reported. Echocardiography demonstrated a large (1 X 1.5 cm) vegetation on the anterior mitral leaflet protruding into the ventricle during diastole. The left atrium was enlarged and Doppler showed mitral regurgitation. Excision of the vegetation during effective antibiotic treatment involved no complications. Although histologically the endocarditis was in the early stage of healing, surgical removal of large, floppy vegetations is advocated because of the unpredictable risk of catastrophic embolization.

Anti-Bacterial Agents↗

The internal mammary artery as subclavian artery substitute in repair of coarctation of the aorta with subclavian flap technique.

In three children, aged 11, 11 and 13 years, long isthmic tubular hypoplasia of the aorta technically precluded resection and end-to-end anastomosis. The coarctation was instead corrected by means of a subclavian flap. Anastomosis between the distal end of the left internal mammary artery and the descending aorta permitted perfusion of the remaining portion of the subclavian artery. At invasive reexamination 6 months after surgery, there was adequate functional and anatomic relief of coarctation in all three children. The three mammary artery-aorta anastomoses were patent, which probably prevented the potential ischemia of the left arm after ligation of the subclavian artery.

Adolescent↗

Cuff pressures and Doppler gradients after coarctectomy. A long-term follow-up.

Fourty-six adult patients operated on as children with resection and end to end anastomosis because of coarctation of the aorta were studied. The age at operation was 7 to 13 years (mean age 10 years) and at follow-up 18 to 28 years (mean age 21 years). Arm and thigh cuff pressure was measured at rest, during and immediately after submaximal exercise. The systolic gradients were also estimated using continuous wave Doppler. Systolic blood pressure at rest was 150 mmHg or more in 12 patients (26%). The cuff pressure at rest correlated well with arm-leg gradients at rest and at work, and also with the Doppler gradients at rest. Doppler gradients slightly underestimated invasively measured gradients. The results imply that postoperative hypertension was explained by residual mechanical obstruction.

Adolescent↗

Amphetamine secretion in breast milk.

The excretion of amphetamine in human breast milk was studied in a nursing mother with narcolepsy, who was treated with 20 mg daily of a racemic preparation of amphetamine. The concentration of amphetamine was 3 and 7 times higher in breast milk than in maternal plasma on the 10th and 42nd days after delivery. Small amounts of amphetamine were found in urine samples from the infant.

Adult↗

Magnetic resonance imaging and angiography for the assessment of coarctation of the aorta.

Fifteen patients ranging in age from 9 to 25 years (median age 10 years), with coarctation of the aorta, were investigated with magnetic resonance (MR) imaging pre- and postoperatively. Three patients were examined because of suggested re-stenosis. Both MR examination and cineangiography were performed in 11 patients. The two techniques were comparable concerning the evaluation of both the site and the severity of coarctation as well as of the occurrence of collateral vessels. MR was considered suitable to replace angiography in the pre- and postoperative assessment of coarctation. The patients were preferably examined with a surface spine coil with ECG-gated sagittal, transverse and parafrontal images. The parafrontal images were necessary in order to minimize mistakes due to partial volume effects at the coarctation site. A surface coil placed over the sternum considerably improved the visualization of the internal mammary arteries.

Adolescent↗