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Biomedical subjects

M Hafez

Publications and source records attributed to M Hafez.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

HLA antigens and idiopathic epilepsy.

Fifty-two mentally normal Egyptian children with idiopathic epilepsy were human leukocyte antigen (HLA) typed. They were divided into two subgroups: generalized tonic-clonic seizures (36 cases) and absences (16 cases). When the frequencies of HLA antigens were compared statistically with those of 120 normal controls, HLA-A9 was found to be significantly higher in the total epilepsy group and the two subgroups. This finding, together with the low HLA-A9 gene frequency in our group of normal Egyptians as compared with other ethnic populations, strongly suggests an association between antigen A9 and one or more of the polygenes controlling the development of idiopathic epilepsy. The relative risk indicated that persons having antigen A9 are 16 times more susceptible to epilepsy than persons lacking it.

Adolescent↗
PubMedDate not supplied

Handling of induced hypercalcaemia in children with rheumatic and rheumatoid affections.

Induced hypercalcemia in rheumatic and rheumatoid children revealed the following : 1. Rheumatic and rheumatoid patients deal more effectively with induced hypercalcemia than control children. 2. A higher percentage of infused calcium in these patients is retained. This may by due to higher calcitionin activity relative to controls. 3. Induced hypercalcemia resulted in an increase in urinary 17 OH C.S. This is suggested to be due to stimulation of the adrenal cortex. These findings suggest that calcium infusion is an effective additional measure in the treatment of rheumatic and rheumatoid affection in the absence of contraindication to calcium.

Calcium↗
PubMedDate not supplied

Calcium and phosphorus metabolic changes in children with hepatic bilharziasis.

Investigations were done to study the calcium and phosphorus metabolic changes in 35 children with hepatic bilharziasis, of whom 12 were ascitic. Thirteen normal children served as controls. Despite a normal serum level of both calcium and inorganic phosphate in the Bilharzial group, yet both were increased in urine. The mean values obtained from the ascitic fluid were 70% and 90.2% of their serum levels, respectively. The corrected creatinine clearance was significantly diminished, while PEI was significantly increased, and the % TRP significantly decreased, with still a more marked decrease in the ascitic cases. Following a phosphate lead the serum inorganic phosphate level showed a significantly more rapid lowering in both bilharzial groups, as compared to the control group. On the other hand bilharzial cases responded to the intravenous calcium load by a significant retention of calcium in the serum.

Adolescent↗