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Biomedical subjects

M Hafeez

Publications and source records attributed to M Hafeez.

13 recordsLinked to original sources
PubMed2001

Anomalous circumflex coronary artery: benign or predisposed to selective atherosclerosis.

Anomalous origin of the circumflex coronary artery from the right sinus of Valsalva is the most common coronary anomaly and is usually considered benign. Although several researchers in the past believed that aberrancy predisposes this vessel to accelerated atherosclerosis, this could not get wide acceptance owing to lack of convincing data. To examine the suggestion that atherosclerosis affects the anomalous circumflex artery more severely, the authors reviewed the clinical and angiographic features of patients with this anomaly identified from 2,684 coronary angiography procedures performed between January 1998 and March 2000 at their institution. The degree of atherosclerotic narrowing in the anomalous artery was compared with that in other coronary arteries in the same patient as well as in the nonanomalous circumflex arteries in controls. For comparison 3 control subjects were selected for each patient with anomalous circumflex artery, matched by age, sex, and clinical presentations. The results showed earlier and greater degree of atherosclerotic narrowing of the anomalous artery as compared to the other coronary arteries in the same patients as well as to nonanomalous circumflex arteries of age- and gender-matched control subjects with similar clinical characteristics. However, this predilection for atherosclerosis was evident only in anomalous vessels arising from the right side and pursuing a retroaortic course. The anomalous artery was responsible for myocardial infarction in 3 patients, all of whom were 60 years or older. Two of the patients with this anomaly and myocardial infarction underwent successful angioplasty with stent placement for symptomatic relief.

Age Distribution↗
PubMed1999

Detection of Taenia solium cysticercosis in pigs by ELISA with an excretory-secretory antigen.

Serodiagnosis of Taenia solium cysticercosis in pigs was conducted by an enzyme-linked immunosorbent assay with an excretory-secretory antigen. The antigen was obtained by in vitro cultivation of the cysticerci in a synthetic medium RPMI 1640. The sensitivity and specificity of the ELISA in detecting infection in pigs reared on free range was 92% and 100%, respectively. In addition, 33.33% of pigs in which infection could not be detected at meat inspection were found positive by ELISA. However, none of the sera from a group of farm-reared pigs were positive. No cross reactions were observed in pigs that contained either the cysticerci of Taenia hydatigena or hydatid cysts.

Animals↗
PubMed1991

Pathology and clinical features of gastro-intestinal lymphoma in Saudi Arabia.

The histopathology and clinical presentation of 19 cases of primary gastrointestinal lymphoma is described. Our patients are similar to others in the Middle East but have a lower incidence of diarrhoea and malabsorption. All revealed a widespread chronic inflammatory background. Four patients with primary gastric lymphoma had endoscopic biopsies from the duodenum; these biopsies were completely free from tumour but showed a moderate to severe diffuse lymphoplasmacytic infiltrate. Electron microscopy shows that tumour cells penetrate basement membranes and invade the epithelium which becomes thin and attenuated. Substances which inhibit lymphocyte tropism might be useful in preventing intestinal ulceration. The MALT concept has been found useful in classification of the tumours. Two patients with unusual mesenteric node histology are described and it is thought that the appearances may indicate a substantial capacity for differentiation in the group of tumours.

Adult↗
PubMed1989

Bioavailability, disposition kinetics and renal clearance of ampicillin following three routes of administration in sheep.

Bioavailability, disposition kinetics and renal clearance of ampicillin were investigated in 8 sheep following intravenous (i.v.), or intramuscular (i.m.) injection of 10 mg/kg or oral administration of 20 mg/kg dose. Peak of absorption was achieved in 26 +/- 9 min (mean +/- SD) after i.m. and 85 +/- 24 min after oral administration. The relative bioavailability of i.m. injected drug was 95 +/- 20 per cent compared to only 37 +/- 7 per cent following oral administration of double the dose. The disposition kinetics parameters of ampicillin were comparable in sheep with all three routes of drug administration. The renal clearance of ampicillin varied between 0.20 and 0.62 ml/min.kg while total body clearance was 50 to 64 ml/min.kg. The fractional urinary excretion of ampicillin in the first 8 hours after dosing was less than 1 per cent of the dose by all three routes.

Administration, Oral↗
PubMed1984

Case report: CT findings in lumbosacral agenesis.

This case describes a newborn paraplegic male with lumbosacral agenesis and related congenital anomalies, including bilateral hip dislocations, arthrogryposis, talipes equinovarus, as well as neurogenic bladder with urine incontinence. An extra-dural tumor, surgically excised and diagnosed as a lipoma, was identified on computed transaxial scans to be adjacent to an abruptly terminating dural sac. Caudal to the sac the scans demonstrated partial fatty replacement of muscle bundles and direct articulation of the iliac wings. A follow-up myelogram delineated the subarachnoid space, but could not distinguish the tumor from a deformed sac secondary to lumbar defects. Computed tomography is thus recommended as part of the general radiologic protocol for fully evaluating the spatial orientation and anomalies of this spinal defect.

Abnormalities, Multiple↗
PubMed1981

Studies on amphistomiasis in Andhra Pradesh (India) VI. Immunization of lambs and kids with gamma irradiated metacercariae of Cercariae indicae XXVI.

The life span and the pathogenicity of amphistomes developing from Cercariae indicae XXVI (Paramphistomum epicilitum) were considerably reduced when the metacercariae were gamma-irradiated at 2 krad or 3 krad. The higher irradiation dose resulted in the complete absence of the flukes in infected animals. Single vaccination of lambs and kids with 3000 metacercariae irradiated at 2 krad or 3 krad stimulated a significant degree of resistance against challenge with 5000 non-irradiated metacercariae. The resistance was more pronounced in the group vaccinated with metacercariae irradiated at 3 krad.

Animals↗
PubMedDate not supplied

The c/b ratio in the radiological monitoring of the hip joint in congenital dislocation of the hip.

We report a method of monitoring hip joint development for congenital dislocation of the hip in children. The c/b ratio was measured on serial radiographs of 41 hips in 38 patients. The measurement was compared to c/b ratio obtained from normal hips. It was used to detect concentric reduction or its loss by migration of the femoral head during growth. The age at diagnosis ranged from 8 months to 10 years 6 months. The normal c/b ratio was found to change little with age. Deviation of the c/b ratio from normal in congenital dislocation of the hip resulted in a poor outcome and identified cases requiring further surgical intervention. This measurement of c/b ratio is simple and accurate, using easily determined points. The graphic display promotes critical analysis of situation and allows selection of cases at risk for treatment.

Child↗