Biomedical subjects

M H Torosian

Publications and source records attributed to M H Torosian.

58 records · Page 4Linked to original sources

PubMedDate not supplied

Unique presentation of a granular cell tumor as a paratracheal mass.

An unusual presentation of a granular cell tumor is reported with a review of the natural history and pathologic characteristics of this tumor. Our patient was asymptomatic and presented with a mass in the inferior right neck on routine physical examination. Preoperative radiologic evaluation suggested a parathyroid adenoma but the normal parathormone level was inconsistent with this diagnosis. At surgery, a firm mass was identified inferior to the right lobe of the thyroid gland and was found to represent a granular cell tumor densely adherent to the trachea. This case demonstrates a unique presentation for this relatively rare neoplasm which was treated with complete surgical resection.

Adult↗

PubMedDate not supplied

A simplified procedure for creating a urinary conduit in patients with a colostomy.

A simplified procedure for constructing a urinary conduit is described in patients who have already undergone fecal diversion with colostomy. Two patients are described in whom this method was utilized to create a urinary conduit without the need for an intestinal anastomosis. This procedure is especially suited to high-risk surgical candidates with comorbid medical conditions, multiple previous surgical procedures or prior pelvic radiotherapy in whom avoiding an intestinal anastomosis can significantly reduce postoperative morbidity. This simplified method for creating a urinary conduit is described in two patients and discussed as related to alternative methods for establishing supravesicular urinary diversion.

Adenocarcinoma↗

PubMedDate not supplied

A significant methotrexate-glutamine pharmacokinetic interaction.

Previous studies indicate that glutamine-supplemented diets decrease the enterocolitis associated with methotrexate administration. The influence of glutamine on the pharmacokinetics of methotrexate and the formation of its major hepatic metabolite, 7-hydroxy-methotrexate was examined in 36 adult, female Lewis rats. Animals were randomly assigned to receive either a 3% glycine-supplemented solid diet (GLY; 25.0% protein; 17.6 kJ/g, or 4.2 kcal/g) or a 3% glutamine-supplemented solid diet (GLN; 25.0% protein; 17.6 kJ/g, or 4.2 kcal/g) ad libitum for 35 days. Animals were separated into two groups (serum methotrexate pharmacokinetics, n = 20; or methotrexate renal elimination, n = 16) and given a 10 mg/kg dose of methotrexate. There was a 25% decrease in mean methotrexate total serum clearance in the GLN group compared with the control group (0.63 +/- 0.09 L.h-1.kg-1 and 0.47 +/- 0.13 L.h-1.kg-1, respectively, p = 0.01). Renal methotrexate elimination was decreased by 65%. There was no significant difference in methotrexate volume of distribution or half-life between the two groups. Glutamine decreases methotrexate systemic clearance, thus exposing the host as well as the tumor to greater methotrexate concentrations.

Administration, Oral↗

PubMedDate not supplied

Spontaneous pelvic hematoma simulating neoplasm: case report and literature review.

Spontaneous hematomas are rare and can present with acute or chronic symptoms. Our patient presented with deep vein thrombosis of the lower extremity associated with a spontaneous pelvic hematoma. This lesion was radiologically and clinically indistinguishable from a soft-tissue neoplasm. The case of a spontaneous pelvic neoplasm in an otherwise healthy young man is presented and the literature reviewed regarding issues of differential diagnosis and clinical management.

Adolescent↗