Biomedical subjects
M H Thomas
Publications and source records attributed to M H Thomas.
Letter: Plasma gold levels.
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Letter: Azathioprine and severe vaccinia.
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Chrysotherapy. A prospective study.
A 4-year prospective clinical study of chrysotherapy was designed to reexamine old beliefs and traditions, and to test potentially new approaches to chrysotherapy. The standard weekly dosage of 50 mg was compared to that based on 1 mg/kg body weight; no significant differences were found. The rapidly absorbed aqueous thiomalate was compared to the slowly absorbed oil repository thioglucose; the latter produced significantly less side effects and an appreciably higher percentage of improvement. Almost half (43%) of nonresponders on standard regimen had a satisfactory clinical response at higher dosage levels without increase in toxicity. Some of these findings vary so much with traditional beliefs and practices that the authors urge caution in their interpretation. But generally speaking these problems are technical and do not detract from the conviction that chrysotherapy is valuable and comparatively safe in the management of rheumatoid arthritis and that it deserves more widespread application in clinical practice.
Determination of sulfamethazine in swine tissues by quantitative thin-layer chromatography.
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Women and specialty choice: why not anesthesiology?
The number of women in all medical specialties increased during the 1970s and 1980s. Anesthesiology residency programs experienced unprecedented growth from 1980 to 1986. We reviewed statistics published by the American Medical Association to investigate the relationship between the increase in female residents in all specialties compared to that for individual specialties including anesthesiology, pathology, surgery, pediatrics, obstetrics/gynecology, radiology, internal medicine, and psychiatry. We found an above average rate of growth for female residents in gynecology, pediatrics, and internal medicine; pathology, radiology, psychiatry, surgery, and anesthesiology showed a below average rate of growth. Studies have shown a correlation between gender and choice of specialty. Factors influencing the differences in choice and the decrease in the percentage of women choosing anesthesiology are unknown.
Simultaneous determination of oxytetracycline, tetracycline, and chlortetracycline in milk by liquid chromatography.
A simple, rapid procedure is described for the simultaneous quantification of 3 tetracycline drugs in bovine milk. Samples are prepared by dilution with an EDTA/phosphate buffer solution and filtration through a molecular weight cutoff filter. Analytes are concentrated on-column using a reverse-phase gradient elution system of oxalic acid, acetonitrile, and methanol. The limits of quantitation are approximately 15-50 ng/mL and the limits of detection are 10-20 ng/mL, depending on the compound. For oxytetracycline, over the range 50-1200 ng/mL, the average recovery and intralaboratory coefficient of variation were 97% and 4.1%, respectively. Over the same range, these parameters were, respectively, 97% and 5.0% for tetracycline, and 89% and 6.4% for chlortetracycline. The applicability of this procedure is demonstrated by separation and detection of incurred tetracycline residues in milk from treated animals.
Myxoma masquerading as polyarteritis nodosa.
A patient who presented with multisystemic symptoms is described. A diagnosis of polyarteritis nodosa was made after arteriographic demonstration of multiple aneurysms in the mesenteric and splenic circulations. The occurrence of a 2nd myocardial infarction in the absence of markers of activity of polyarteritis nodosa led to coronary arteriography which demonstrated a large left atrial myxoma confirmed by echocardiography. Surgical removal of the myxoma was followed by resolution of most of his symptoms and serves to point out the mimicking of a generalized vasculitis by cardiac myxoma.
Evaluation of a degradation method for nitrosamine wastes.
Nitrosamines are being used with increasing frequency in biomedical laboratories. Disposal of these potentially carcinogenic compounds requires a decontamination procedure that is simple, efficient, and economical. Degradation of nitrosamine wastes by alkaline reduction and the analytical techniques for evaluating this method have been explored. Efficiencies of degradation vary from 9.0 to greater than 99.9 percent of a group of ten nitrosamines.