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Biomedical subjects

M H Rathore

Publications and source records attributed to M H Rathore.

At least 37 records · Page 2Linked to original sources
PubMed1993

Effect of immunity to the carrier protein on antibody responses to Haemophilus influenzae type b conjugate vaccines.

The anticapsular antibody responses to some Haemophilus influenzae type b (Hib) conjugate vaccines may be enhanced by prior or simultaneous administration of the carrier protein used in the conjugate. Currently, there are two Hib conjugate vaccines licensed in the USA for use in infants beginning at 2 months of age: Hib polysaccharide coupled to an outer membrane protein complex of Neisseria meningitidis (PRP-OMPC), and Hib oligosaccharides conjugated to CRM197, a non-toxic mutant diphtheria toxin (HbOC). The PRP-OMPC conjugate vaccine is immunogenic in infant monkeys and infant humans in the absence of carrier priming or additional carrier vaccination. The mechanism responsible for this immunogenicity is unknown but may relate to the adjuvanticity of the OMPC carrier. In contrast, data from infant rhesus monkeys and infant humans suggest that there may be a need for vaccination with diphtheria toxoid in order to maximize anti-PRP antibody responses to the HbOC conjugate. In addition, immunization with HbOC alone appears to be insufficient to elicit an antibody response to diphtheria toxoid. Thus, the need for additional vaccination with diphtheria toxoid in order to generate consistent anti-PRP antibody responses to HbOC may be a result of failure of the CRM197 protein carrier to elicit T-cell help. In infants in whom diphtheria-tetanus-pertussis (DTP) vaccination is deferred because of medical contraindications, vaccination with the PRP-OMPC conjugate would appear to be preferable to HbOC because of the ability of the former to elicit antibody responses in the absence of diphtheria toxoid vaccination.

Animals↗
PubMed1993

Human herpesvirus 6.

Human herpesvirus 6 (HHV-6) is a relatively recently discovered virus. Although systematic studies on the spread of this virus are lacking, considerable data have been collected regarding the prevalence of HHV-6 infection. A number of laboratory methods are available for the diagnosis of HHV-6 infection, but currently these tests are usually available only in research laboratories. HHV-6 has been implicated in a number of infectious and lymphoproliferative and malignant diseases. While the relationship between HHV-6 and human immunodeficiency virus is not yet clear, HHV-6 has been shown to cause exanthema subitum and acute febrile illness in young children. At this time no adequate antiviral therapy is available for HHV-6 infection.

Herpesviridae Infections↗
PubMed1993

Ehrlichia chaffeensis and Rochalimaea antibodies in Kawasaki disease.

Sera from 38 patients with Kawasaki disease were tested for immunofluorescent antibodies to Ehrlichia chaffeensis, Rochalimaea henselae, and R. quintana Oklahoma. Only 2.5% of the patients tested positive for E. chaffeensis, and 5% were positive for R. henselae and R. quintana Oklahoma. Our data suggest that Ehrlichia and Rochalimaea spp. do not play a unique role in the etiology of Kawasaki disease.

Antibodies, Bacterial↗
PubMed1993

Human ehrlichiosis in Florida.

Human ehrlichiosis has been relatively recently identified in the United States. We report a case of human ehrlichiosis recently diagnosed in Jacksonville. A high index of suspicion in an appropriate clinical setting is needed to make this diagnosis. This disease is most often confirmed by serologic tests. Patients benefit from antimicrobial therapy.

Animals↗
PubMed1992

Infection due to Ehrlichia canis in children.

Human ehrlichiosis has a wide spectrum of presentation. This report presents two cases that demonstrate the diversity of the manifestation of ehrlichiosis, from life threatening to a mild viral-like illness. Diagnosis requires an understanding of the epidemiology and clinical manifestation of this infection and a high index of suspicion.

Child, Preschool↗
PubMed1992

Suppurative group A beta-hemolytic streptococcal infections in children.

Group A beta-hemolytic streptococci (GABHS) have once again become an important cause of serious suppurative disease in children. A 100% increase in the rate of GABHS bacteremia and an increased frequency in GABHS bacteremia in previously healthy children were observed in 1989 through 1990 compared with 1984 to 1988. Streptococcal isolates were characterized and patient demographic data were tabulated from children hospitalized with GABHS suppurative infections in 1989 through 1990. The differences in clinical manifestations and strains of GABHS were examined in patients with bacteremia, with or without focal site of infection, and in those with focal infections without bacteremia. Bacteremic children were significantly younger and had higher white blood cell counts at admission. No patient had a toxic shock-like syndrome. Although no specific strain was associated with suppurative infections, serum opacity reaction-negative organisms were more frequently associated with focal infections without bacteremia. The data suggest that GABHS may have become more virulent. Physicians should consider GABHS as an important cause of serious suppurative infection in children.

Age Factors↗