Biomedical subjects
M H Mehta
Publications and source records attributed to M H Mehta.
Huge swelling over the tip of tongue.
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Cholelithiasis associated with a variant of annular pancreas.
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The radiologic diagnosis of internal jugular vein thrombosis.
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Congenital thoracic wall deformities.
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Congenital midline subgaleal cyst.
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Iniencephalus apertus.
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Enlarged thymus treated by steroids.
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Hepatitis B immune globulins and HIV antibodies.
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Long-term follow-up of fused and unfused idiopathic scoliosis.
We reviewed 77 unfused and 91 fused patients with idiopathic scoliosis who first attended between 1949 and 1965. Both groups were re-examined at least 10 years after reaching skeletal maturity, with attention to progression of the Cobb angle, increased in vertebral rotation, back pain and psychosocial problems. We found that spinal fusion protects the scoliotic spine from further deterioration during adult life except for those with severe curves and marked rotation. Fusion also significantly reduced the incidence of severe pain and allowed patients to carry out heavy physical work, but did not confer complete immunity from backache. Surgery improved the appearance, but patients were not always completely satisfied with the cosmetic result.
Common pancreaticobiliary channels and their relationship to gallstone size in gallstone pancreatitis.
Bile reflux into the pancreatic duct after impaction of a stone in a common pancreaticobiliary channel has been suggested to be the initiating factor in gallstone pancreatitis. Such reflux would require that the impacted stone be smaller than the length of the common channel. The incidence of common channels was studied and gallstone size was compared with common channel length in patients with gallstone pancreatitis and those with cholelithiasis or choledocholithiasis without pancreatitis. Sixty-seven per cent of patients with gallstone pancreatitis had a common channel present on intraoperative cholangiography versus 32% of patients with cholelithiasis or choledocholithiasis without pancreatitis (p less than 0.005). Common channel length was greater than the diameter of the smallest stone in nine of 27 patients with gallstone pancreatitis and in 13 of 109 patients with cholelithiasis or choledocholithiasis without pancreatitis (p less than 0.025). In conclusion, common channels are more frequent in patients with gallstone pancreatitis than in patients with other biliary tract disease. Furthermore, gallstone pancreatitis is associated with stones that are smaller than the common channel, which favors obstruction of both pancreatic and bile ducts while allowing reflux of contents between them.
Characterisation of collagen from normal and scoliotic human spinal ligament.
Acid-soluble and pepsin-soluble collagens have been isolated from spinal ligaments of normal and scoliotic individuals. Polyacrylamide gel electrophoresis of native and cyanogen bromide-treated collagens, and amino acid analysis, showed that the ligament collagen is almost all of the Type I variety with only trace amounts of Type III present. There was no evidence for abnormal ratios of collagen alpha-chains, or underhydroxylation of proline and lysine in the scoliotic ligament. These results indicate that collagen biochemistry is normal with respect to type, post-translational modification and cross-linking in spinal ligaments of patients with idiopathic scoliosis. Elastin and proteoglycan were only minor components of the ligaments. The nature of the non-collagenous part of the ligament is unknown, although it contains some proteins with a hydrophobic nature.
Day surgery for cataracts and iris-clip implant insertions.
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Intravenous arteriography - a photographic alternative to digital arteriography.
Intravenous arteriography is a useful method which should be considered for those patients in whom arterial catheterization is a risk. The technique permits visualization of the entire aorta and its major branches. While inferior to conventional arteriography, the diagnostic information provided by intravenous arteriography is adequate for most patients with aortic aneurysm or major stenotic lesions. Detail can be improved by using subtraction techniques. Images comparable to those produced by digital angiography can be obtained at relatively low cost.
Flow-chart for sequential cholecystography.
A protocol designed to integrate oral cholecystography with ultrasonography and scintiscanning of the gallbladder is presented. The planned use of these modalities will permit a 95% clinically useful assessment on a single visit to the x-ray department.
Intra-abdominal sepsis--ultrasound evaluation.
The advent of grey-scale ultrasound has made this facility an irreplaceable tool for diagnostic imaging techniques. Although well established in obstetric management, its application to abdominal "body" scanning is not yet fully realized and accepted. These case presentations demonstrate the role of ultrasound in the diagnosis, localization and clinical management of patients with intra-abdominal sepsis. It is emphasized that ultrasound should be used early in the work-up of such problems and is rapidly becoming the investigation of choice. The diagnostic information provided facilitates management, reduces the need for complex investigations and occasionally makes surgery unnecessary.
Pain provoked scoliosis. Observations on the evolution of the deformity.
The case reports of 5 children with scoliosis provoked by painful vertebral lesions of osteoid osteoma and eosinophilic granuloma reveal that the final outcome of the deformity is determined by the interaction of 2 factors: the age of the child (in relation to his growth velocity); the duration of symptoms. Complete resolution in 2 children with scoliosis of 10 months' and one year's duration respectively, and partial regression of a curve which has been present for 6 years in another child draws attention to the fact that spontaneous correction of structural scoliosis can and does occur in a growing child. In the light of this and other evidence it is suggested that early idiopathic scoliosis could possess the potential for spontaneous correction.