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Biomedical subjects

M H Machado

Publications and source records attributed to M H Machado.

11 recordsLinked to original sources

[Hypertension associated with pregnancy. Epidemiologic study of 311 consecutive cases].

The epidemiologic aspects of 311 consecutive cases of hypertension associated with pregnancy seen in the Department of Obstetrics and Gynecology, Hospital de Santa Maria/University of Lisbon Medical School between January 1st 1988 and December 31st 1992, are reviewed. Seventeen cases were multifetal pregnancies. Using the criteria proposed by the American College of Obstetricians and Gynecologists the cases were classified as follows: Mild preeclampsia, 64 cases (7 in twins); severe preeclampsia 50 cases (5 in twins); chronic hypertensive disease, 81 (1 in twins); chronic hypertension with superimposed preeclampsia, 16 (all singleton pregnancies); transient hypertension of pregnancy, 84 (4 in twins); unclassified hypertension, 16 cases of singleton pregnancies. No maternal deaths occurred. The most frequent maternal complications (eclampsia, HELLP syndrome, abruptio placentae and acute renal failure) were seen in preeclampsia (mild and severe forms). Only 2 significant maternal complications were observed in the cases of superimposed preeclampsia on chronic hypertensive disease. In the other groups maternal complications were seldom seen. Excepting in transient hypertension, perinatal morbidity and mortality were frequent in all groups, specially in severe preeclampsia and superimposed preeclampsia, when the delivery occurred before 34 weeks; after that time of pregnancy there were no neonatal deaths in any of the groups and intrauterine growth retardation and fetal distress were the most common fetal complications in all groups. In the whole, uncomplicated chronic hypertension and transient hypertension of pregnancy were the clinical situations in which maternal and perinatal complications were milder and less frequent. No perinatal problems were found in the group of unclassified hypertension.

Chronic Disease

[Deep venous thrombosis during pregnancy].

Deep vein thrombosis is a rare event during pregnancy. A case which occurred in a 27-year-old nullipara at 36 weeks of pregnancy is reported. Related literature is reviewed, specially in what concerns diagnosis and therapy.

Adult

[The HELLP syndrome in pregnancy-related hypertension].

During a 5-year period, 13 cases of HELLP syndrome were seen in hypertensive patients in the Obstetrics Department, Santa Maria Hospital, Lisbon. In 7 cases the syndrome occurred antepartum and in 6 during early early puerperium; gestational age and clinical features were very different from case to case. Four cases of eclampsia and 2 cases of acute renal failure occurred in 5 patients; there were 2 intrauterine deaths. Maternal mortality was nil. HELLP syndrome always implicates an important hepatic involvement with deleterious effects on the clinical status of the patients. Since the syndrome is often diagnosed in the puerperium and major complications seen in our study group occurred in that period, we conclude that all hypertensive patients must be closely monitored during the first 48 hours after delivery.

Adult

[Teratogenic effects of exogenous agents].

Since the identification of Thalidomide as a potent human teratogen, the possible effects of a large number of drugs, and chemical, physical and environmental agents, on the embryo and the fetus have been raised without support of scientific demonstration. During the last ten years, a large number of papers were published on this issue, making the understanding of teratogenic mechanisms and effects a new field for investigation. This review is to show the recent trends and concepts on human teratogenesis induced by extrinsic agents, making it clear that the majority of them can not be seen as harmful to humans.

Abnormalities, Drug-Induced