Search PubMed⌕ Search

Biomedical subjects

M H Kheradpir

Publications and source records attributed to M H Kheradpir.

12 recordsLinked to original sources
PubMed1990

Partial splenectomy and partial splenic attachment for the treatment of portal hypertension.

Between 1973 and 1983 6 children with portal hypertension were treated at the University Children's Hospital Medical Centre in Teheran by transpositioning the spleen into the thorax. In one case with splenomegaly, ascites and 4 years of severe bleeding, this procedure was not possible. We therefore performed a partial splenectomy 7 years ago, with the view of a transpositioning into the thorax at a later date. Follow-up examinations revealed disappearance of the symptoms of portal hypertension. This led us to believe that this procedure could be adopted for the treatment of portal hypertension as an alternative to splenic transpositioning into the thorax and shunt operation. The precipitation and increase in collateral circulation with this method leads to rapid improvement.

Child↗
PubMed1990

Childhood urolithiasis in Iran with special reference to staghorn calculi.

Between 1972 and 1984 148 children with urolithiasis were studied and managed at the University Clinic Children's Hospital of Teheran. In 125 children the calculi were in the upper and in 23 children in the lower urinary tract. The maximum incidence was between the ages of 5-8 and 12 years. 25 children had malformations and 16 had metabolic disorders. Cystinuria was observed in 6 and xanthinuria in 3 cases. The main constituents of calculi analyses in the upper urinary tract were calcium oxalate followed by ammonium acid urate. In the lower urinary tract ammonium acid urate and oxalate were seen with equal frequency, followed by uric acid. 16 children had staghorn calculi with an age profile of 5-13 years. Predominant symptoms were flank pain and gross hematuria. In 4 cases the calculi were bilateral. The calculi were removed successfully by pyelotomy and extensive pyelolithotomy. In 2 cases with more branched-out staghorn calculi and separate fragments, a logitudinal extensive nephrotomy was performed. In the absence of recurrent stones, renal growth and function were satisfactory postoperatively. In the majority of the cases the analyses of the staghorn calculi revealed phosphate.

Adolescent↗
PubMed1989

Double ureter in children: surgical management.

Among 25 cases of double ureter which required surgical treatment, six were accompanied by ureterocele. Interpelvic anastomosis was performed in two cases with uretero-ureteral reflux. En bloc reimplantation was performed for ten double ureters, three of which had common ureteral orifice with reflux in both ureters. In three other cases there was a common segment with low bifurcation and ureteroureteral reflux which had to be excised in order to create two ureteral orifices in the bladder. Heminephrectomy with excision of the ureterocele combined with a simultaneous reimplantation of the ipsilateral ureter was performed in three cases. These cases were accompanied by a large ureterocele and reflux in the ipsilateral ureter. Upper-pole nephrectomy and partial ureterectomy without excision of the stump and ureterocele was performed in one case of small ureterocele without reflux. Excision of the ureterocele combined with en block reimplantation was performed in one case with relatively well preserved renal tissues. Follow-up results were satisfactory in the majority of the cases.

Child, Preschool↗
PubMed1989

[Sacral teratomas--organized forms].

Between 1939 and 1971 31 cases of sacrococcygeal teratomas were observed at Zurich Children's Hospital, in 5 cases the tumor contained well-developed organs. From 1970 to 1982 25 cases of sacrococcygeal teratomas were identified at Teheran Children's Hospital. In 2 of these cases the tumors were organized. At the same time we observed 2 other cases, one a well differentiated retroperitoneal teratoma, the other an ectopic third leg in the lumbosacral region. In the so-called organized teratomas we found all organs with the exception of heart, lung, kidney, eyes and vertebra. Malignant degeneration was not observed. It is probable that such organized tumors develop from a concentration of rich pluripotent cells at the end of the coccyx. An explanation for ectopic extremities could be the deplacement of pluripotent cells at an early stage of embryonic development.

Choristoma↗
PubMed1985

Childhood urolithiasis in Iran: a comparative study on the calculi composition of 121 cases.

Within 12 years, 165 cases of urolithiasis were observed at the Children's University Hospital of Teheran. The incidence of urolithiasis amounts to 1 case in 300 paediatric hospitalizations. 160 calculi from 121 children were analysed by various methods: semiquantitative chemical analysis (Mercognost), x-ray diffraction, polarising microscopy on thin sections. In about 25% of the cases metabolic disorders or malformations were found responsible for urolithiasis. In 100 cases, stone formation was attributed to the upper and in 21 cases to the lower urinary tract. Calcium oxalates are the most frequent constituents, followed by ammonium acid urate. The core of the stones in the upper tract was mostly composed of calcium oxalate. Ammonium acid urate was the second important core component, but occurred especially enriched in the lower urinary tract. On the basis of these and literature data, the lack of ammonium acid urate in juvenile stones in Europe and the USA seems surprising. Thus, it must be assumed therefore, that ammonium acid urate is a key to understanding the formation of endemic calculi. The cases studied support that with increasing standard of living, the incidence of bladder stones decreases.

Adolescent↗
PubMed1985

Partial splenectomy in the treatment of thalassaemia major.

From 1981-1982 we performed partial splenectomy in 6 children with beta-thalassaemia major as an alternative to splenectomy to reduce transfusion and to preserve some splenic immune function. In two of our young patients with transfusion requirements of 150 ml/kg/year, where more than 2/3 of the spleen was removed, the number of transfusions was significantly reduced with prolonged intervals, haemoglobin rose with a marked improvement in the general condition, nutrition and growth. There were no major post-operative complications. 2 years' follow-up revealed no infection without sepsis prophylaxis.

Blood Transfusion↗
PubMed1985

[Partial splenectomy in homozygous beta-thalassemia].

Six children, 2 1/2 to 6 years old, with homozygous beta-thalassemia underwent partial splenectomy as indicated by splenomegaly and high blood transfusion requirement. A marked reduction of blood requirement has been achieved in 2 children with an annual blood transfusion volume up to 150 ml per kg body weight. The other four children required total splenectomy as blood requirement remained high and significant splenomegaly developed within few weeks after the partial splenectomy. The immunological function of the spleen residue remains still controversial and needs further evaluation. Partial splenectomy might be indicated therefore only in selected children with homozygous beta-thalassemia.

Blood Transfusion↗
PubMed1984

[An unusual form of bladder exstrophy].

A rare case of bladder exstrophy is presented. It is described as being similar to a superior vesical fissure, but it differs from it by the abnormal course of the urethra which is separated from the bladder and runs along the clitoris.

Bladder Exstrophy↗
PubMedDate not supplied

Morgagni-hernias during infancy.

Five cases of Morgagni hernia observed in Teheran Children's Hospital in 1973-1983 are reported. Four of the diagnosed cases were infants less than seven months of age and all presented respiratory symptoms: two of them accompanied by associated malformations. In four cases the hernia was present on the right side and in one on the left. The most common contents of the hernial sac were colon, small-bowel, liver, omentum and stomach. A transthoracic approach was advocated only in cases with solid content in the hernial sac or when differentiation from a solid mass was difficult. For the other cases the transabdominal approach was preferred. The operation chosen of treatment, gave satisfactory results in all the patients.

Abnormalities, Multiple↗
PubMedDate not supplied

Calculus anuria in childhood.

The incidence of calculus anuria is relatively high in Iran. Eighteen children with this picture were studied in our departments between 1972 and 1984. The cause of anuria was bilateral obstruction by the calculi (14 cases), unilateral obstruction with a nonfunctioning kidney (3 cases) or aplasia on the other side (1 case). As demonstrated by our study, the cause of stone formation was a metabolic disorder in 50% of the children. This indicates that with anuria created by calculi formation, more consideration should be given to the possibility of metabolic disorders than has so far been the case. Further research should therefore be carried out in this respect, particularly in cases of the lower age range with indications of parental consanguinity, multiple and bilateral calculi, repeated calculi and repeated admissions, which were frequently observed by us.

Anuria↗