Search PubMed⌕ Search

Biomedical subjects

M H Jensen

Publications and source records attributed to M H Jensen.

At least 37 records · Page 2Linked to original sources
PubMed1984

Penetrating peptic ulcer and aortic aneurysm with aortogastric fistula.

The case of a 71-year-old woman with an aortogastric fistula caused by the combination of a penetrating peptic ulcer and an aortic aneurysm is reported. Treatment consisted of excision of the ulcer and primary prosthetic grafting of the aorta. Recovery was uneventful. The possible relationship between aortic aneurysm and peptic ulceration is discussed, as are therapeutic alternatives.

Aged↗
PubMed1983

Late changes following single dose roentgen irradiation of rat small intestine.

In female Wistar rats a 10 cm long exteriorized mid small intestinal segment was roentgen irradiated with 17, 19, 21 and 23 Gy as single exposures. Animals were killed in groups of 3 at intervals of 6 weeks from 2 to 50 weeks following irradiation. Irradiation injury was assessed using 8 macroscopic and histopathologic parameters, and an injury score for each animal was calculated. The parameters used were divided in 2 subgroups, early and late alterations, showing different types of development. The score for the early alterations decreased from 2 to 20 weeks following irradiation and then remained constant. The late alterations increased and seemed to stabilize about 8 weeks following irradiation. After the initial 20 weeks there was no progression of irradiation injury.

Animals↗
PubMed1982

Experimental fetal infection with bovine viral diarrhea virus. I. Virological and serological studies.

The serological and virological results of an experimental infection of bovine fetuses with bovine viral diarrhea virus are presented. Four fetuses, 120-165 days gestational age, were inoculated in utero with a second passage virus strain. Two fetuses received a sham-inoculum. A humoral immune response in the virus-inoculated fetuses, was demonstrated three weeks later. In three fetuses only IgM and IgG1 were detectable. The serum from the fourth fetus also contained IgG2 and IgA. Bovine viral diarrhea virus-neutralizing antibodies were detected in two fetuses. These two fetuses inoculated at 135-150 days gestational age, represent the youngest reported bovids, giving a specific response in three weeks following an experimental infection with bovine viral diarrhea virus. The fetal sera did not contain heat-labile factors, which could mediate the neutralization. The virus was not reisolated from any of the fetuses, but viral antigen was nevertheless demonstrated by immunocytochemical methods in sections of several of the fetal organs, primarily lymphoid tissues.

Animals↗
PubMed1981

The 5'-nucleotidase complex in sera from patients with gall stones--electrophoretic patterns and substrate specificity.

Various purine and pyrimidine mononucleotides seem to be dephosphorylated by a 5'-nucleotidase complex composed of four fractions in sera from both patients with gall stones and from normal subjects. Agarose gel electrophoresis, with the addition of Triton X-100, demonstrated that the faster (F-) fraction of the enzyme complex and the slower (S-) fraction both consisted of two sub-fractions (termed alpha and beta). The enzyme complex showed a uniform substrate specificity pattern, which was independent of the absolute enzyme activity.

5'-Nucleotidase↗
PubMed1981

Theophylline inhibition of renal and cerebral nucleoside formation.

1 Theophylline inhibits the enzymatic formation of purine nucleosides, among these adenosine (dephosphorylated adenosine 5'-monophosphate), in kidney and brain of the rat. 2 Some pharmacological effects of theophylline on regional blood flow and electrophysiological activity of the nervous system may be caused by inhibition of the endogenous formation of adenosine.

Animals↗
PubMed1981

Demonstration of bovine viral diarrhea virus antigen in cryostat- and paraffin-sections of bovine tissues by the immunoperoxidase technique.

An immunoperoxidase technique (IPT) for the demonstration of bovine viral diarrhea virus (BVDV) antigen in tissue sections is presented. The method was applied to cryostat sections and to alcohol fixed, paraffin embedded specimens. The specificity as well as the sensitivity of the IPT corresponded to the immunofluorescence technique (IFT), and the specimen processing methods used represented an improvement of the histomorphological preservation of tissue structures.

Animals↗
PubMed1980

The 5'-nucleotidase activity in normal human serum. Electrophoretic patterns and substrate specificity.

Both the electrophoretic patterns and substrate specificity of the total 5'-nucleotidase activity at pH 7.4 in serum from 10 normal adults (19-49 years) were identical using various purine and pyrimidine mononucleotides as substrates. Different purified alkaline phosphatases were studied at the same time in the same manner. The serum enzymes showed substrate specificity qualitatively similar to that of the bovine liver enzyme. The electrophoretic study showed two fractions for both the liver enzyme and the serum enzymes with the different substrates, indicating that each of these are dephosphorylated by the same two, mutually different, enzyme molecules. Each of the other enzymes showed only a single fraction, which was identical for each enzyme with the various substrates.

5'-Nucleotidase↗
PubMed1980

Urinary loss of oxypurines in hypoxic premature neonates.

The daily urinary excretion of the oxypurines hypoxanthine, xanthine and uric acid during each of the first 3 days of life was determined in premature infants without hypoxia (PI) and in hypoxic premature infants (HPI) with the respiratory distress syndrome. The loss of uric aic was statistically significantly greater in the HPI during days 1, 2, and 3 of life, and so was the loss of xanthine on days 1, and 2, but not on day 3. As to the loss of hypoxanthine, no difference could be shown. In both groups of infants the excretion of hypoxanthine and xanthine together made up about 2% of the total oxypurine loss for each day, the loss of xanthine being the greater of the two. The results did not seem to bear relation to differences between the two groups concerning urinary output, birth weight, gestational age, method of delivery, or administration of exogenic purines. So it appears that the increased loss of oxypurines in HPI is caused by the impact of hypoxia, probably owing to be compromised cellular respiration with a subsequent general displacement of the purine metabolism in the catabolic direction.

Apgar Score↗
PubMed1979

Dephosphorylation of purine mononucleotides by alkaline phosphatases. Substrate specificity and inhibition patterns.

Three purine mononucleotides, adenosine-, inosine- and guanosine monophosphate, were used as substrates at pH 7.4 and at 10.4 for three alkaline phosphatases (orthophosphoric-monoester phosphohydrolase (acid optimum), EC 3.1.3.1) containing similar phosphate-binding serine groups at their esteratic sites. Substrate specificity was found for the enzymes from calf intestine and bovine liver. Alkaline phosphatase from Escherichia coli was nonspecific. A substrate-dependent and pronounced inhibition with the purine analogue 1,3-dimethyl xanthine was found for the enzymes from intestine and liver, but not for alkaline phosphatase from E. coli. A substrate-independent and pronounced inhibition was found for all three enzymes with the phosphomonoester p-nitrophenol phosphate as the inhibitor. Alkaline phosphatases may play an important role in the regulation of the intracellular content of purine mononucleotides.

Adenosine Monophosphate↗
PubMed1978

The hazard of acute epiglottitis.

This report is based on a 3 1/2 year's study of 33 cases of acute epiglottitis with 3 child deaths. Suspicion of acute epiglottitis in children with respiratory distress is always an indication for rapid direct laryngoscopy under general anaesthesia with intubation, and preparation for tracheotomy and bronchoscopy. Should the diagnosis of acute epiglottitis not be excluded during this procedure, then a free airway should be ensured by endotracheal intubation, even in cases of apparently less severe character, where the procedure would seem to be more prophylactic than therapeutic. Intubation is often very difficult. It is concluded that the patient should be received at the hospital by an E.N.T.--anaesthetic team conversant with the treatment of this potential killer.

Acute Disease↗
PubMed1977

Oxypurine excretion in normal newborn infants.

Hypoxanthine, xanthine, uric acid, 6-hydroxypurine, 2,6-hydroxypurine and 2,6,8-hydroxypurine, respectively, are the catabolic products of purine-containing compounds in the human body. Each of the compounds was determined, by enzymatic spectrophotometry, in the 24-hour urine samples of 23 newborn infants. The hypoxanthine excretions on the 1st, 2nd and 3rd days were 1.1 (0.7-1.6), 0.9 (0.1-1.4) and 0.7 (0.1-1.5) mumol/24 h/kg body weight. The xanthine excretion in the 1st, 2nd and 3rd days was: 0.5 (0.3-1.2), 0.6 (0.3-2.0) and 1.2 (0.4-1.9) mumol/24 h/kg body weight. The uric acid excretion in the 1st, 2nd and 3rd days was: 61 (33-150), 61 (20-142) and 76 (40-127) mumol/24 h/kg. All the values are given as median and 10% percentiles. The hypoxanthine excretion decreased significantly (p less than 0.05) and the xanthine increased correspondingly throughout the 3 days (p less than 0.05). The excretion of hypoxanthine plus xanthine showed no significant change throughout the 3 days, and comprised approximately 2.5% of the total oxypurine excretion.

Adult↗