Search PubMed⌕ Search

Biomedical subjects

M H Grunwald

Publications and source records attributed to M H Grunwald.

At least 73 records · Page 4Linked to original sources
PubMed1991

Atypical clear cell acanthoma.

Two cases of clear cell acanthoma (CCA) with marked signs of cellular atypia and mitotic figures are reported. Although the nature of CCA is not completely understood, it is considered to be a benign epithelial tumor. Our cases show that these lesions can develop malignant features.

Aged↗
PubMed1991

[Macrophage migration inhibition factor as a diagnostic aid in drug eruptions].

The diagnostic value of the macrophage migration inhibition factor (MIF) test was evaluated in 90 patients with the clinical diagnosis of drug eruption. There were 40 males and 50 females who ranged in age from 15-84 years (mean 61.0). Controls were 120 patients being treated with drugs without adverse reactions and 21 patients with dermatologic disorders unrelated to drugs. Positive MIF responses for 1 or more drugs were observed in 71.1% of the patients with drug eruptions as compared to 4.2% and 9.5% of the control groups, respectively (p less than 0.001 for both). The proportion of positive MIF responses in those in whom drugs were implicated (45.2%) was significantly greater (p less than 0.0001) than in those with eruptions in whom drugs were not implicated (18%). The MIF test may be of aid in the diagnosis of drug eruptions and in the identification of the offending drugs.

Adolescent↗
PubMed1990

Acne keloidalis-like lesions on the scalp associated with antiepileptic drugs.

A man developed acne keloidalis-like lesions in the scalp during treatment with diphenylhydantoin and carbamazepine for epilepsy. These drugs were suspected to play a role in the pathogenesis of this skin disease in an unusual location, based on clinical evidence and on the in vitro test, mast cell degranulation (MCD).

Acne Keloid↗
PubMed1990

Macrophage migration inhibition factor (MIF) in drug eruption.

A controlled study was conducted to evaluate the macrophage migration inhibition factor test as a diagnostic aid in 50 patients with drug eruption. Two groups of patients served as controls: group A, 110 patients being treated with drugs without known cutaneous adverse reactions, and group B, 15 patients suffering from dermatologic disorders unrelated to drugs being taken. Positive macrophage migration inhibition factor responses were found toward a variety of drugs in 35 (70%) of the patients with drug eruptions, with no relation to the type of eruption or the duration of drug intake. The percentage of positive macrophage migration inhibition factor responses toward drugs in the patients with drug eruptions was higher than that in the two control groups (4.5% and 6.7%, respectively). The percentage of positive macrophage migration inhibition factor responses recorded for clinically "suspected" drugs was significantly higher than that recorded for the "nonsuspected" drugs.

Cell Migration Inhibition↗
PubMed1989

Specific cutaneous infiltrates in chronic myelogenous leukemia.

Specific leukemic infiltration of the skin is possible in all types of leukemia, and occurs most commonly in monocytic leukemias. We report the case of a 76-year-old woman with chronic myelogenous leukemia who showed specific cutaneous lesions one month before she died. In the absence of other signs of accelerated disease or blast crisis, cutaneous lesions should be considered an ominous sign in chronic myelogenous leukemia.

Aged↗
PubMed1988

Pseudocarcinomatous hyperplasia.

Pseudocarcinomatous hyperplasia is not fundamentally a hyperplasia of epidermal epithelium, but rather a hyperplasia of adnexal epithelia, namely, of follicular infundibula and eccrine ducts. All examples of pseudocarcinomatous hyperplasia are responses to an underlying inflammatory or neoplastic process. That process can usually be discerned beneath the pseudocarcinomatous hyperplasia in the biopsy specimen. Application of criteria that pertain mostly to architectural pattern (silhouette) enables pseudocarcinomatous hyperplasia to be differentiated histopathologically from squamous cell carcinoma.

Carcinoma, Squamous Cell↗
PubMed1986

Immunologic alterations in xeroderma pigmentosum patients.

Nine xeroderma pigmentosum (XP) patients were investigated. In comparison to a normal control group the XP patients had a reduced OKT-4 lymphocyte subpopulation, reduced response of lymphocytes to phytohemagglutinin in autologous serum, and diminished delayed hypersensitivity skin reaction. The possible contribution of ultraviolet irradiation to the observed immunologic alterations, and the link of these alterations to the susceptibility of patients for malignant transformation is discussed.

Adolescent↗
PubMed1986

Lichenoid eruption due to hydrochlorothiazide. Diagnostic aid of macrophage migration inhibition factor (MIF) test.

The case of a lichenoid photosensitive eruption induced by hydrochlorothiazide is described. The macrophage migration inhibition factor test identified hydrochlorothiazide as the offending drug out of the several suspected drugs taken by the patient. It is suggested that an allergic reaction towards hydrochlorothiazide was involved in the development of the photosensitive lichenoid eruption in this case.

Aged↗
PubMed1985

Coexistence of psoriasis vulgaris and bullous diseases.

The coexistence of psoriasis vulgaris and bullous diseases has been described in the literature, mainly with bullous pemphigoid. In the majority of cases the bullous eruption has been thought to be related to antipsoriatic treatment. We describe nine cases of psoriasis vulgaris that were associated with bullous diseases: five bullous pemphigoid, one cicatricial pemphigoid, and three pemphigus vulgaris. The association between psoriasis vulgaris and these bullous diseases may be explained on an immunologic basis.

Aged↗