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Biomedical subjects

M H Greene

Publications and source records attributed to M H Greene.

At least 109 records · Page 6Linked to original sources
PubMed1978

Familial non-Hodgkin lymphoma: histologic diversity and relation to other cancers.

Familial non-Hodgkin lymphoma (NHL) cases were classified according to the histologic criteria (modified) of Rappaport, to determine the extent of morphologic similarities of the tumors. In four families affected members had different tumor histologies that may be observed in an individual patient as the lymphoma progresses. In two families, the affected relatives had tumors of seemingly discordant histology. These tumors may nonetheless be etiologically related as indicated by the pattern of laboratory abnormalities, especially immunologic, in affected as well as unaffected members. The 20 cases had a reversal of the sex ratio (M/F) usually seen in NHL: 0.5 instead of 1.3. Other tumors observed in these families included primary hepatocellular carcinoma, pulmonary adenocarcinoma, Hodgkin disease, and acute lymphocytic leukemia - all of which have been associated with inborn or acquired immunodeficiency states.

Carcinoma↗
PubMed1978

Subsequent cancer in patients with chronic lymphocytic leukemia--a possible immunologic mechanism.

Among 4,869 patients with chronic lymphocytic leukemia (CLL) from the series of the End Results Program of the National Cancer Institute, Bethesda, Maryland, second primary cancers developed in 234 patients, compared to 204.9 expected. The risk was significantly elevated for malignant melanoma, soft-tissue sarcomas, and lung cancer. The frequency of rectal cancer was also elevated, but not significantly. The excess risk for these specific sites persisted throughout the period of follow-up, suggesting a susceptibility state that complicated the leukemic process rather than suggesting methodologic, diagnostic, or therapeutic effects. Immunologic defects to CLL may be involved in the etiology of excess risk for these sites, because a similar array of nonlymphoid tumors was seen following therapeutic immunosuppression among renal transplant recipients.

Colonic Neoplasms↗
PubMed1978

Disseminated cryptococcosis presenting as palpable purpura.

Disseminated cryptococcosis with palpable purpura as the initial clinical manifestation developed in a patient with diffuse histiocytic lymphoma. Cryptococcal vascular injury in a thrombocytopenic cancer patient best explains this previously unreported presentation of cryptococcosis. Purpuric presentations of disseminated fungal infection are likely to increase in frequency as cancer therapy becomes more aggressive.

Biopsy↗
PubMed1978

Precursor lesions in familial melanoma.

Familial occurrences of malignant melanoma may be related to an inherited syndrome of precursor cutaneous lesions with distinct clinical and histologic features. Recognition of the syndrome in the relatives of melanoma patients identifies a subset of family members at high risk for melanoma, facilitating their early diagnosis and treatment. Further studies of these families may provide insight into the biology of malignant melanoma and the pathophysiology of malignant transformation in benign nevi.

Female↗
PubMed1977

Nasopharyngeal cancer among young people in the United States: racial variations by cell type.

U. S. mortality and incidence statistics for nasopharyngeal cancer showed a fourfold excess risk of sarcomas in white children under age 10, and a fourfold to sevenfold excess of carcinomas in teen-age blacks. Mortality from nasopharyngeal carcinomas in young people was greater in the South than in the North, with the excess mortality in blacks linked to rural residence and low socioeconomic status. These and other characteristics of nasopharyngeal carcinoma in young persons suggested that environmental (perhaps infectious) agents are involved in this age group. These patterns contrasted with nasopharyngeal carcinomas developing after age 25, when the rates predominated in Chinese Americans. Nasopharyngeal cancer in the United States had three age peaks, with racial and epidemiologic distinctions that seemed to reflect different etiologies.

Adolescent↗
PubMed1976

The spread of addiction-the role of the "average addict".

A survey of an accidental sample of 100 addict-clients indicates that approximately two-thirds of addicts induct others into the heroin culture. Typically, the number of new users recruited in this way is no more than one or two new users contacted by each experienced addict. The problems of interdicting the transmission process is complicated not only by the large numbers of persons involved in that process, but is further complicated by the fact that new users are recruited relatively early in the experienced users' careers when they are least likely to be known to treatment or law enforcement officials. The work of interdicting the spread of phenomenon is still further complicated by the fact that heroin is transmitted between friends under circumstances the experienced user can characterize, if with some possible exaggeration, as involving an effort to share a pleasurable experience and/or to meet others' requests.

Adult↗
PubMed1975

Controlling the abuse of illicit methadone in Washington, DC.

Methadone hydrochloride has been found to be medically safe when administered in the setting of a well-organized heroin addition treatment program. The abuse of illicit methadone, outside the therapeutic setting, has aroused considerable controversy, particularly with regard to the public health hazards of primary methadone addiction, overdose, abuse, and childhood poisoning. We attempted to document the nature and extent of these negative aspects of the diversion of methadone into the illicit drug market, using data collected between 1969 and 1974 in the District of Columbia. The data illustrate the severe problems created by the widespread availability of illicit methadone, and document that, with the appropriate controls, the large-scale use of methadone in addiction treatment is feasible with minimum risk of methadone addiction and overdose in the community.

Administration, Oral↗
PubMed1975

The resurgence of heroin abuse in the District of Columbia.

Prospectively collected drug abuse trend surveillance data suggest that the rate of heroin use in Washington, D.C. is rising following a two year decline in the magnitude of this problem. Supportive data include increased potency of street level heroin, increased numbers of heroin-related deaths, increased detection of heroin positive urine specimens in the D.C. Superior Court arrestee population, increased demand for addiction treatment services and rising property crime rates. Increased prevalence of heroin use has not yet been associated with an increase in incidence, suggesting that former heroin users have begun to use once again following a period of abstinence. Analysis of heroin specimens seized across the United States suggests that cities formerly dependant upon European (white) heroin have now developed a new heroin distribution system which supplies Mexican (brown) heroin. This has offset the reduction in heroin use observed during 1972-1973 concomitant with the East Coast heroin shortage and widespread introduction of addiction treatment services.

Adult↗
PubMed1975

Evolving patterns of drug abuse.

The sharp rise in drug abuse in the past decade has led to the development of new sources of information on drug-abuse trends. These include surveys, drug-related emergencies, drug-abuse treatment, hepatitis rates, and various types of law enforcement information. This paper summarizes data currently available for heroin, marijuana, cocaine, amphetamines, and barbiturates. Heroin use occurred in epidemic form in the late 1960s. Some cities, which had experienced a subsequent decline in heroin use, recently have reported an increase again. Marijuana use has increased steadily. The abuse of amphetamines and barbiturates appears to be growing. Trends on cocaine use are unclear. The development of ongoing, quantitative data-collection systems is beginning to clarify many of the issues regarding drug-use patterns and trends. With the possible exception of survey data, however, each indicator provides data only on selected segments of the drug-using population.

Amphetamines↗