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Biomedical subjects

M H Brooks

Publications and source records attributed to M H Brooks.

72 records · Page 4Linked to original sources
PubMedDate not supplied

A spurious markedly increased serum estradiol level due to an IgA lambda.

OBJECTIVE: To alert physicians about the potential for erroneous laboratory determinations of hormone levels and emphasize the need to assess the overall clinical situation as well. METHODS: We present a case report of a woman with a dramatically increased serum estradiol (E(2)) level on radioimmunoassay and review the studies that led to the conclusion that this laboratory finding did not reflect her true estrogen status. RESULTS: In a 41-year-old woman, an unnecessary surgical procedure was performed because of a falsely increased serum E(2) level and a unilateral ovarian mass. The markedly increased serum E(2) measured by radioimmunoassay was found to be attributable to an IgA lambda that bound to the 125 I-labeled tracer of the assay. CONCLUSION: When repeatedly abnormal hormone levels and the clinical picture seem discrepant, use of a different assay method should be considered.

Journal Article↗
PubMedDate not supplied

Effect of fine needle aspiration biopsy on the histology of thyroid neoplasms.

We evaluated the effect of fine needle aspiration biopsy (FNAB) upon the histology of thyroid adenoma and differentiated thyroid carcinoma. When surgery was performed within three months of FNAB, infarction was found histologically in 8/82 (9.8%) of the tumors. It was extensive in four patients, with one patient having no residual neoplastic cells identifiable within the nodule. No infarction was seen in the histologic specimens from patients with similar pathology whose surgery was performed without prior FNAB. These findings confirm previous reports that infarction may be caused by FNAB and can be so extensive as to interfere with the histologic diagnosis.

Adenocarcinoma↗