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Biomedical subjects

M H Aprison

Publications and source records attributed to M H Aprison.

At least 55 records · Page 3Linked to original sources
PubMed1977

A rapid column chromatographic procedure for the routine measurement of taurine in plasma of normals and depressed patients.

A rapid method has been developed for the routine measurement of taurine in plasma. A preliminary clean-up step has made it possible to assay multiple samples in a relatively short period of time using the excellent sensitivity and specificity of the analytical column of the automatic amino acid analyzer. The speed and specificity of the method permits its use for the routine measurement of taurine in blood samples. Employing this method, a value of 45+/-4nmol taurine per ml platelet free plasma (mean+/-S.E.M.) was obtained for normal healthy adults. Analysis of plasma from depressed patients who are free of drugs as well as from depressed patients under treatment with drugs gave values of 29+/-2 and 25+/-3 nmol taurine per ml platelet free plasma (mean+/-S.E.M.), respectively.

Adult↗
PubMed1976

Cholinergic changes during conditioned suppression in rats.

Levels of acetylcholine were significantly elevated in the telencephalon and diencephalon + mesencephalon of rats killed by near-freezing during conditioned suppression of food-reinforced lever pressing, whereas levels of serotonin, dopamine, and norepinephrine were not altered. These neurochemical changes were not seen in rats serving as controls for conditioning experience, activity levels, or stimulus presentation.

Acetylcholine↗
PubMed1976

Neurochemical correlates of behavior: levels of amino acids in four areas of the brain of the rat during drug-induced behavioral excitation.

The levels of GABA, aspartate, glutamate, glycine and alanine were determined in 4 specific brain areas (telencephalon, diencephalon-mesencephalon cerebellum and pons-medulla oblongata) of rats killed during a period of drug-induced behavioral excitation. Behavioral excitation was obtained in adult, male Wistar rats working on a Sidman shock-avoidance schedule following administration of 2 mg/kg tetrabenazine (TBZ) 18 hr after iproniazid (50 mg/kg) pretreatment. When compared to trained animals (working on the avoidance schedule but receiving no drugs), the excited rats had increased levels of GABA in the telencephalon and diencephalon-mesencephalon, decreased levels of aspartate in all 4 brain areas, and a lower content of glycine in the pons-medulla region. The changes in the levels of aspartate in all areas of the brain, GABA in the diencephalon-mesencephalon, and glycine in the pons-medulla were significantly correlated (p less than 0.01) with the degree of excitation. It was observed that avoidance training alone produced increases in the levels of four amino acids: aspartate in telencephalon and cerebellum, GABA in cerebellum, and glycine and glutamate in the pons-medulla. The injection of iproniazid alone or iproniazid followed by TBZ into naive animals had little effect on the levels of the five amino acids. The data are discussed in terms of aspartate and GABA interacting as neurotransmitters with cholinergic and catecholaminergic and/or serotonergic neurons to produced the behavioral excitation.

Amino Acids↗