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Biomedical subjects

M Guslandi

Publications and source records attributed to M Guslandi.

150 records · Page 9Linked to original sources
PubMedDate not supplied

Sustained enhancement of gastric HCO3 secretion in humans by enprostil.

Twelve healthy, male volunteers were treated for ten days, in double-blind conditions, with either enprostil, a PGE2 derivative, at a dose of 35 micrograms bid or with placebo. Before and after treatment fasting gastric juice was collected and basal bicarbonate secretion was measured by Feldman's method. In the enprostil group a statistically significant (p less than 0.01) increase in gastric HCO3 output was detectable 12 hours after the last dose. That finding, which is in keeping with the results of acute single-dose studies, suggests that stimulation of bicarbonate secretion by enprostil is not merely a transient phenomenon involved in the prevention of mucosal injury, but a lasting effect that may contribute to the ulcer-healing activity of the drug.

Adult↗
PubMedDate not supplied

Double-blind trial of pirenzepine versus sucralfate in the treatment of endoscopic duodenitis.

Thirty dyspeptic patients with endoscopic evidence of mild to moderate (nonerosive) duodenitis were randomly assigned to treatment with 50 mg of pirenzepine twice daily or 2 gm of sucralfate twice daily for four weeks. Posttreatment endoscopy revealed normalization of duodenal mucosa in half of the patients in each treatment group. The severity of dyspeptic symptoms was significantly reduced in both groups, with no significant between-group differences.

Adolescent↗
PubMedDate not supplied

Does Helicobacter pylori affect gastric microcirculation?

Chronic gastritis is frequently accompanied by Helicobacter pylori infection and associated with a reduced gastric blood flow. To investigate the possible relationship between the two phenomena, 20 outpatients with histological antral gastritis with or without concomitant duodenal ulcer, 10 of them Hp positive and 10 negative, were selected and compared with a matched group of ten healthy controls. Mucosal blood flow was measured in the gastric antrum by laser Doppler flowmetry during endoscopy. In both groups of patients with chronic gastritis the values were significantly lower than normal (p < 0.01), the difference between Hp+ and Hp- cases being statistically not significant. In six of the Hp+ patients, eradication therapy with omeprazole+amoxycillin was carried out because of concomitant duodenal ulcer. At 6 weeks eradication was successful in four patients, but perfusion values remained unchanged. Mucosal blood flow in chronic gastritis is reduced regardless of concomitant H. pylori infection and eradication has no influence on gastric perfusion. Therefore H. pylori appears to have no direct effects on gastric microcirculation.

Adult↗
PubMedDate not supplied

Enhancement of gastric mucosal blood flow with sulglycotide.

Twelve patients with dyspepsia whose gastric abnormalities ranged from diffuse reddening of the mucosa to multiple erosions were treated for 4 weeks with oral sulglycotide, a sulphated glycopeptide with known gastroprotective and ulcer-healing properties. Before and after treatment, gastric mucosal blood flow was assessed by means of laser Doppler flowmetry. A significant (P < 0.01) increase in mucosal perfusion was observed after sulglycotide treatment, suggesting that enhancement of mucosal blood flow may contribute to the therapeutic properties of the drug.

Administration, Oral↗
PubMedDate not supplied

Measurement of rectal blood flow by laser Doppler flowmetry in inflammatory bowel disease.

BACKGROUND/AIMS: Vascular alterations have been suggested as pathogenic factors in inflammatory bowel disease, particularly Crohn's disease. The aim of our study was to assess rectal blood flow in patients with active inflammatory bowel disease involving the rectum. METHODOLOGY: Endoscopic measurement of rectal blood flow was performed by laser Doppler flowmetry in 45 subjects divided into three groups: healthy controls, ulcerative colitis and rectal Crohn's disease. RESULTS: Rectal perfusion was found to be significantly impaired in patients with ulcerative colitis, but not in those with Crohn's colitis. CONCLUSIONS: Our results confirm the role of local ischemia in ulcerative colitis, but do not support the theory that vascular factors play a key role in the pathogenesis of Crohn's disease.

Adult↗