Biomedical subjects
M Gupta
Publications and source records attributed to M Gupta.
Hematological changes produced in mice by ochratoxin A.
The effects of ochratoxin A (5 mg/kg, intraperitoneal) on clotting time, hemoglobin, total count of red blood cells and white blood cells and differential count of white blood cells were studied in mice. This mycotoxin caused a significant decrease in the hemoglobin level and in the total count of red blood cells. Among white blood cells there was a significant increase in small lymphocytes and a significant fall in the count of neutrophils, basophils and monocytes in treated mice. The administration of ochratoxin A also prolonged the clotting time by more than 6-fold.
Profile of morbidity and nutritional status and their effect on the growth potentials in preschool children in Delhi, India.
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The influence of cations on the permeability of the outer membrane of Salmonella typhimurium and other gram-negative bacteria.
The high sensitivity of rough mutants of Salmonella typhimurium, S. minnesota, and Escherichia coli 08 (i.e. with defects in the carbohydrate core of the lipopolysaccharide) to several antibiotics and to the dye gentian violet could be substantially reduced by the addition of cations (Mg2+, Na+) into the growth medium. One heptoseless mutant of S. typhimurium (chemotype Re) and its isogenic smooth parent strain were studied in more detail. The uptake of gentian violet was about 20% in the smooth strain, about 60% in the Re strain grown without additional cations, but decreased to about 15% in the same strain, when cations had been present during growth. In all cases, almost 50% of the gentian violet taken up by the cells was membrane-bound. The total membranes of the Re strain grown in nutrient broth without additional Mg2+ ions were reduced in the 36K and 34K major outer membrane proteins compared with the smooth strain; when grown with added cations the Re total membranes (and even whole cells) did not revert to the protein pattern of the smooth strain.
Factors influencing the rate and extent of in vitro demineralization.
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Trichobezoar--clinical diagnosis (a case report).
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Endophthalmitis after trabeculectomy.
Two cases of late endophthalmitis after trabeculectomy surgery are described. Despite intensive antibiotic therapy, the visual end result in both cases was poor. The incidence of endophthalmitis after trabeculectomy, according to this report is similar to that after Scheie's procedure, but less than that after trephination. A possible cause of endophthalmitis is the anterior dissection of the superficial scleral flap into the cornea.
Nutritional status of urban and rural preschool children in Western Rajasthan (in and around Bikaner City): I--Anthropometric study.
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Immunization status of children. Comparison between rural, Rural Health Training Centre (RHTC) and urban community.
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Nutritional status of urban and rural preschool children in Western Rajasthan (in and around Bikaner City). II. Clinical study.
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Blockade of ovulation by ergocornine in rats and its reversal by progesterone.
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Study of histopathological evidence of alpha I anti-trypsin deficiency in Indian childhood cirrhosis.
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Adriamycin cardiotoxicity: early detection by systolic time interval and possible prevention by coenzyme Q10.
Recent work suggests that adriamycin (ADM) cardiotoxicity results from the depletion of coenzyme 10 (CoQ10) activity in myocardial mitochondria. CoQ10 is indispensable in the bioenergetics of coupled respiration of oxidative phosphorylation. It exists naturally in mitochondria, especially in the myocardium. Bertazzoli et al have reported a decrease in ADM-induced cardiotoxicity by CoQ10 both in vivo and in the in vitro isolated rabbit heart. The systolic time interval (ATI) (pre-ejection period/left ventricular ejection time ratio) has been shown to increase (indicating cardiac dysfunction) with increasing doses of ADM. We have noted a gradual increase in the STI in eight of ten patients receiving 200-500 mg/m2 of ADM. Two of these eight patients had congestive heart failure (CHF) at doses of 200 and 350 mg/m2. The continued daily oral administration of 50 mg of CoQ10 beginning with the first dose of ADM resulted in a decreased incidence of cardiac dysfunction, and a gradual increase in STI occurred in only two of eight patients receiving 200-400 mg/m2 of ADM. CHF was observed inone patient at a dose of 350 mg/m2. It is suggested that CoQ10 was nontoxic and did not affect the antitumor activity or modify the ADM-induced bone marrow toxicity. A prospective randomized study comparing ADM with and without CoQ10 is in progress.
Foreign body in the oesophagus.
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The Klipple Feil syndrome: (a case report).
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Study of alpha1 antitrypsin levels in Indian childhood cirrhosis.
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