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Biomedical subjects

M Gummerus

Publications and source records attributed to M Gummerus.

At least 19 recordsLinked to original sources
PubMed1992

Comparison of enoxaparin, a low-molecular-weight heparin, and unfractionated heparin, with or without dihydroergotamine, in abdominal hysterectomy.

The effects of administration of low-molecular-weight heparin (enoxaparin 20 mg) once a day, of unfractionated heparin (5000 IU twice a day, and of unfractionated heparin (2500 IU) plus dihydroergotamine (0.5 mg) twice a day were assessed in 100 patients undergoing abdominal hysterectomy. The test medications were given subcutaneously 2 hours before operation and for 3 days thereafter. There were no thromboembolic complications. Intraoperative blood loss, wound haematomas and blood loss via drains during four days after operation were similar in the three groups. None of the 37 patients receiving enoxaparin experienced major postoperative bleeding. Six out of 31 patients receiving unfractionated heparin without dihydroergotamine and two out of 32 patients receiving dihydroergotamine in addition experienced major bleeding necessitating re-operation and/or blood transfusion, (P < 0.05). Enoxaparin caused less major bleeding than unfractionated heparin with or without dihydroergotamine in patients undergoing hysterectomy.

Dihydroergotamine↗
PubMed1987

Prophylactic long-term oral tocolysis of multiple pregnancies.

After admission to hospital for bed rest, 200 women with multiple pregnancies were randomly allocated to receive either 4 mg of salbutamol orally five times daily, or to receive no drug. After an average of 6 weeks treatment, no difference between the experimental groups could be detected with respect to duration of gestation, birthweight or any other of the outcomes of pregnancy observed.

Albuterol↗
PubMed1986

[Ectopic pregnancy].

In Finland there were 3 193 ectopic pregnancies registered during the years 1973-1976 (1,25% of the newborns) and 4 856 ectopic pregnancies (1,91%) during the years 1977-1980. Also in the State Maternity Hospital Helsinki the ectopic pregnancy rate rose from 0,8% to 1,4%. During the years 1977-1980 241 women were operated on. From 112 patients without postoperative contraception 48% gave birth, 33% remained infertile, 10% had a recurrent ectopic pregnancy and 9% had an abortion. The best results were achieved in the salpingectomy group. In cases of conservative operations expression was more favorable than salpingotomy. With the development of better diagnostic methods the possibility of conservative operations, partial resection of the tube, respectively, later followed by microsurgical anastomosis, will be increased.

Adolescent↗
PubMed1985

Optic neuritis during lactation.

The condition called "lactation optic neuritis" has been previously considered a clinical entity of its own. Four women, who developed optic neuritis within 1-12 months while breast-feeding their infants, were investigated ophthalmologically and neurologically in order, to find specific clinical features for this condition. The course of the disorder was similar to classic optic neuritis without lactation. The clinical history and laboratory findings in three of the four patients suggested a demyelinating disorder. It is possible that the decreased immunosuppressive activity just after pregnancy induces the manifestation of an underlying demyelinating disease. The existence of "lactation optic neuritis," however, is questioned as a separate entity of its own. Lactation together with decreased immunosuppression may merely act as a provocateur in the onset of optic neuritis, which in many cases is the first clinical manifestation of incipient multiple sclerosis.

Adult↗
PubMed1985

Serum salbutamol concentrations during oral and intravenous treatment in pregnant women.

The serum concentration of salbutamol was determined in 29 pregnant women during oral treatment (4 mg five times per day) and in seven during intravenous infusion (6-30 micrograms/min) because of premature labour. The concentration of salbutamol was determined by combined gas-liquid chromatography mass spectrometry. The mean concentration of serum salbutamol was twice as high during intravenous treatment (24; SD 9 ng/ml), than during oral treatment (12; SD 3 mg/ml). During oral treatment, the salbutamol levels were not correlated to maternal height, weight or the incidence or severity of side-effects. The serum concentrations of salbutamol in patients with twin pregnancies did not differ from those with singleton pregnancies. After stopping intravenous treatment, serum salbutamol levels remained high for several hours and oral treatment can be started 4-6 h after stopping intravenous infusion.

Administration, Oral↗
PubMed1985

Best criterion for the assessment of efficacy of tocolysis and choice of most suitable betasympathomimetic.

Over a period of 10 years, 645 patients were treated with six different betasympathomimetics because of threatening premature labor during the 24-36 weeks of gestation. Some 603 comparable patients were analysed with various parameters to find the most suitable criterion for assessing the efficacy of tocolysis and the best tocolytic agent. Delivery after 37 completed weeks proved clinically a sufficient criterion of a successful therapeutic outcome. The various scores did not essentially facilitate comparison of various tocolytics. The combination buphenin (DilaverR) + verapamil (IsoptinR) proved to be the most suitable medication.

Birth Weight↗
PubMed1983

[Tocolysis with hexoprenalin and salbutamol in a clinical comparison].

140 patients with a threatening premature birth at the greater than or equal to 24-less than 37 week of gestation were in this study randomly treated with hexoprenalin or salbutamol. In 77% in the hexoprenalin and in 74% in the salbutamol group the weight of the newborn was greater than or equal to 2500 g. In 66% in both study groups the birth occurred after the completed 37 weeks of gestation. During infusion of hexoprenalin tachycardia in mothers occurred statistically highly significantly less than during salbutamol. 11% of the mothers in the hexoprenalin group had side-effects during infusion compared to 30% in the salbutamol group. The correlation between the tocolysis-index (Baumgarten) and the prolongation-index (Richter) given by the regression lines facilitates in some measure the comparison of different tocolytic drugs concerning its tocolytic effect.

Albuterol↗
PubMed1983

[Toxic shock syndrome following cesarean section].

In this case report we describe the fourth finnish woman with toxic-shock-syndrome (TSS). The illness begun seven weeks after caesarean section abruptly with high fever, abdominal pain, erythematous rash and sore throat. She was discharged after two weeks of hospitalization in a good condition and there was in a follow up time of four years no recurrence.

Adolescent↗
PubMed1982

Decrease of serum oestriol during intravenous hexoprenaline or salbutamol treatment.

Patients with premature labour were treated with intravenous hexoprenaline (18 patients) or salbutamol (10 patients) infusion between 26 and 36 weeks gestation. After at least 12 h infusion, oral therapy was started. Serum total oestriol was determined by radioimmunoassay every 6 h during intravenous beta-mimetic infusion (p less than 0.005). One day after stopping intravenous treatment, and then every day after stopping the infusion, for 4 days. The mean serum total oestriol concentration decreased significantly during the intravenous treatment, serum oestriol returned to pretreatment levels. The results show that fetal monitoring by maternal oestriol determinations is not reliable during intravenous beta-adrenoceptor agonist therapy.

Adult↗
PubMed1982

[Subpartal tocolysis in fetal distress situations].

43 patients in 31-42 weeks of gestation showed fetal distress confirmed by fetal scalp blood measurements and/or cardiotocography. In addition to conventional treatment of intrapartum fetal distress a beta-adrenergic receptor stimulator, fenoterol was given, 1. as iv. bolus of 25 micrograms in two min. 2. iv. bolus of 25 micrograms + iv. infusion of 3-4 micrograms/min or 3. iv. infusion of 3-4 micrograms/min. The suppression of labor was sufficient in 88 per cent and the improvement of fetal condition allowed the avoidance of an emergency operation in 84 per cent. The diagnosis was confirmed in addition to CTG, by fetal scalp blood pH measurements in 65 per cent of cases. The fetal blood pH was 7,20 and BE - 8,77 before therapy, after tocolytic therapy pH 7,23 and BE - 7,53 and in umbilical cord arterial blood pH 7,21 and BE - 12,12. Apgar scores at 1' and 5' averaged 8,0 and 9,1.

Acid-Base Equilibrium↗
PubMed1981

The management of premature labor with salbutamol.

One hundred and eight patients with imminent premature labor in the 24-36th week of pregnancy and with intact membranes were allocated randomly to two groups. Fifty-four patients were treated with intravenous infusion of 12-50 microgram/min of salbutamol (Ventoline) and 4 mg was subsequently given orally at 4-hour intervals. The weight of the newborn was over 2 500 g in 72% of cases. The duration of pregnancy was prolonged by over seven days in 67%, and 37 weeks of pregnancy and more was achieved in 61%. The comparable figures for the control group treated with fenoterol, 3-4 microgram/min and subsequently 5 mg orally at 4-hour intervals, were 78, 80 and 70% respectively.

Albuterol↗
PubMed1981

[Beta-sympathicomimetics, premature birth, and perinatal mortality (author's transl)].

A group of 658 patients hospitalised throughout one year was examined in the 24th to 36th weeks of pregnancy, with the view to finding out, if prematurity and perinatal mortality could be reduced by systematic beta-mimetics therapy of imminent premature birth. Patients with beta-mimetics treatment for imminent premature birth accounted for 112 cases. The proportions of infants with low birth-weight and of perinatal deaths along with beta-mimetics treatment declined with significance by comparison to another review which covered a period between 1968 and 1970.

Adrenergic beta-Agonists↗
PubMed1981

Eisenmenger complex and pregnancy.

Eisenmenger complex is a congenital heart disease, which causes considerable maternal mortality. Data from the literature suggest a maternal mortality of 26%, with an infant survival of 57%. We describe a successful pregnancy and vaginal delivery of a woman with Eisenmenger complex and discuss the problems associated with Eisenmenger complex and pregnancy.

Adult↗