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Biomedical subjects

M Guillot

Publications and source records attributed to M Guillot.

159 records · Page 9Linked to original sources
PubMedDate not supplied

Orf and pregnancy.

A 31-year-old woman presented with orf on the forefingers at 34 weeks of gestation. The disease, contracted after handling sheep a week before, was uncomplicated, and the patient gave birth at term to a normal baby. Although some cases with features suggestive of viremic spread had been described, the authors find an overall benign picture of orf in man and recommend symptomatic therapeutic measures.

Adult↗
PubMedDate not supplied

[General problems posed by prescription medications in children. Point of view of the clinician].

Drug therapy for children arise many a problem for clinical practitioners as pediatric requirements are very specific. Adequate dosage according to various developmental stages (neonate, infant, child, adolescent), specific pediatric forms issued from clinical and pharmacokinetics trials in children, galenic drugs suitable for pediatric use without side effects especially for topical preparations, remodelling of adult forms into pediatric forms without loss of effectiveness are some of the main problems. Furthermore medication compliance and potential hazards connected to misuse of some "over the counter" drugs (antipyretics, vitamins, trace elements) delivered without medical prescription are underscored.

Administration, Topical↗
PubMedDate not supplied

[Neonatal primary hyperparathyroidism caused by clear cell hyperplasia].

Neonatal primary hyperparathyroidism is rare but must be evoke during respiratory distress with thoracic deformity and hypercalcemia. The plasma immunoreactive parathyroid hormone level allows the diagnostic. This case, with diffuse hyperplasia of water-clear cells type, develops rickets of vitamin D deficiency before surgery. A large parathyroidectomy (7/8) was performed and the child is normo-calcemic 2 years after. The time of surgery is function of calcium level.

Female↗
PubMedDate not supplied

[Acute aortic dissection. Prognostic factors, therapeutic indications. 137 cases (author's transl)].

137 patients (92 men and 45 women) with an average age of 58 years (range: 19 to 90 years) were hospitalised between January 1970 and June 1977 for acute aortic dissection. In 107 patients (and in 91 cases during the first 24 hours of hospitalisation) aortography was performed. This examination was found to be greatly reliable when its findings were compared with those at surgical exploration. In the absence of surgical treatment, 69 patients died and 5 survived. Amongst the patients undergoing surgery, 37 died and 27 survived. With the exception of type III dissections, survival appeared to be markedly increased by surgical treatment. Preoperative factors indicative of a poor prognosis included a neurological deficit of central origin, oligoanuria, raised blood urea, disseminated intravascular coagulation and dissection of the superior mesenteric artery or the coeliac trunk.

Acute Disease↗
PubMedDate not supplied

[Prognosis of nephrosis].

Renal biopsy, the introduction of immunohistologic methods and electron microscopy have allowed the differentiation of clinicopathologic entities associated to nephrotic syndrome. Two main categories must be differentiated: in the first, diffuse lesions of the glomerulus, including those secondary to specific diseases the same as those that are apparently primary, are responsible for the increased permeability of glomerular capillaries. Any one of the following clinical signs suggests this category: acute onset with nephritic syndrome, moderate nephritic syndrome, moderate nephrotic syndrome, gross hematuria, persistent hypertension and/or renal failure, poor selectivity of proteinuria and drop in complement serum levels (C3). In the second category, known as idiopathic nephrotic syndrome, the mechanism of disorder of the glomerular capillary is unknown and the nephrotic syndrome is more marked. In most cases with idiopathic nephrotic syndrome, minimal glomerular lesions (MGL) are present. The clinicopathologic correlation among these three types of lesions shows that the type with MGL is characterized by selective proteinuria, absence of hematuria, good response to corticosteroids and good outlook; whereas in types with diffuse mesangial proliferation (DMP) and segmentary sclerosis, proteinuria is frequently non selective, hematuria shows in 50 to 75% of the patients; prognosis is poor. However, MGL, DMP and focal segmentary glomerular sclerosis are not different entities, but represent variants of the same disease. Considering that corticosensitive nephrosis to this moment is the most common cause of the nephrotic syndrome, especially in children under 8 years, renal biopsy should be done only under two circumstances: a) when the clinical symptoms suggest diffuse glomerular lesions and b), when resistance to corticosteroids becomes evident.

Adrenal Cortex Hormones↗