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Biomedical subjects

M Guarrera

Publications and source records attributed to M Guarrera.

At least 19 recordsLinked to original sources

Anagen hairs may fail to replace telogen hairs in early androgenic female alopecia.

BACKGROUND: Male baldness develops because of an increased duration of the lag phase. OBJECTIVE AND METHODS: To assess if this occurs also in balding women we studied 2 women with Ludwig type I-II patterned baldness for 2 years with monthly phototrichograms. Hairs were identified as thick anagen hairs, thin anagen hairs and telogen hairs. RESULTS AND CONCLUSIONS: Most of the hairs followed the expected development, namely they remained thick anagen hairs or they became thick from thin anagen, telogen from thick anagen or thin anagen from telogen hairs. Other hairs, though, became thin from thick anagen or telogen from thin anagen or thick anagen from telogen hairs. Still others did not regrow immediately after being in the telogen phase, leaving an empty space. Some empty spaces were not refilled for a long time. As in men, in balding women tiny bald spots develop corresponding to telogen hairs not replaced in due time.

Adult

Trichodynia.

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Adult

Synthesis and in vitro phototoxicity of 5-(arylmethylene)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ones, a class of potential sunscreens.

A series of 5-(arylmethylene)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6- ones was prepared by reaction of (+)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-one with aromatic aldehydes in an alkaline medium. These compounds can be considered as potential UVB or UVA sunscreens. In vitro phototoxicity tests (photohemolysis and Candida albicans) showed that they exhibit in general a low phototoxicity level.

Bridged Bicyclo Compounds

Is nifedipine phototoxic?

Circumstantial evidence of phototoxicity of nifedipine is poor, being based only on uncontrolled clinical evidence. The authors have assessed nifedipine phototoxicity in vitro by photohemolysis and Candida albicans tests and found it measurable at 10 and 100 micrograms/ml. These dosages exceed the 0.1 microgram/ml blood levels that are usually attained in vivo.

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