[Effects of corticosteroids on the synthesis of proteins in the organism].
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Biomedical subjects
Publications and source records attributed to M Grzywa.
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Authors discussed the actual status of information concerning the disturbances in function: 1) of sorbitol biochemical pathway, 2) myoinositol metabolism and 3) activity of Na(+)-K(+)-ATP-ase related to diabetic hyperglycemia. Preliminary data on the possible benefit of aldo-reductase inhibitors therapy are also presented.
The authors present the results of research on the usefulness of clinical data, thyroid hormones, TSH, antithyroid antibody, HLA estimations and a type of behavior, for prognosing the susceptibility to pharmacological therapy in thyrotoxicosis, specially in Graves disease. The highest chance of predictability was found in patients with small goiter, HLA-DR5 positive with onset of the disease at the age before 40. In general it is difficult to predict the reaction to therapy in individual case with high probability.
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