[Peculiar bilateral opacities].
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Biomedical subjects
Publications and source records attributed to M Grivaux.
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The authors report 9 cases of primary pulmonary lymphoma (PPL). With this report, together with the publication of recent and important studies and with the latest advances in immunology, the principal features of this rare entity are emerging from among other lymphoproliferative pathologies of the lung. As a rule, PPL is a histologically well-differentiated tumour with low malignancy and slow course. Treatment is surgical in localized forms. In extensive forms there is no firmly established treatment, but the absence of clinical symptoms permits therapeutic abstention.
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The authors report a case of lymphangiomatosis (LAM) proven histologically in a 49 year old female. This case benefitted from very detailed CT-scanning (IDM) with characteristic images obtained from the thorax and bilateral renal tumours suggestive of angiomyolipomas. This association seems to be quasi-pathognomic of the disease. The discovery at CT-scanning of cerebral calcification raises a possible connection of LAM with Bourneville's tuberous sclerosis. This CT-scanning study has several points of interest: the early diagnosis of pulmonary lesions which are under evaluated by standard radiography; a complete inventory of the possible localisations of the disease; it enables a possible diagnosis in very frail patients in whom a lung biopsy would be a risk; an ability to assess further progress as there also exists a good correlation between the extent of the disease assessed by TDM and the disturbance in pulmonary function.
A 52-year old woman with systemic scleroderma had been treated since 1978 with factor XIII. The skin lesions had improved, and respiratory lesions had become stabilized. In 1984, she developed a bronchiolo-alveolar carcinoma which was treated by surgery. The authors emphasize that factor XIII is well tolerated and has beneficial effects on the skin and probably also on the lungs, without tachyphylaxis; however, the possibility of a bronchioloalveolar carcinoma occurring cannot be ruled out.
In 54 patients (45 Africans and 9 West-Indians) we searched schistosomiasis and the presence of immunoglobulins E by different tests (total immunoglobulin E levels, measurement of specific IgE, human basophil degranulation test). In patients with an excretion of living eggs we observed 91.6% of positive responses for the II. B. D. T. and 100% for the specific IgE. In cases only identified by examination of rectal mucosa biopsy specimens showing apparently living eggs, we observed 75% and 87.5% of positive responses for the same tests. But in both categories of patients, the parasitological examination is the most important. Moreover the authors observed "false-positive" and "false negative" tests compared with the parasitological results and between the tests. It suggests that the best use of these is in case of very probable schistosomiasis without positive parasitological results.
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Few such observations of beta-blocker-induced lupus have been published in the medical literature. In the index case, the usual criteria were present. Acebutolol withdrawal resulted in rapid clinical improvement. Antinuclear antibodies are still present after nine months follow up. Pathogenic hypotheses are discussed.
Between October 15th 1981 and January 31st 1982, 297 echocardiogrammes were performed in the department of cardiac surgery at Broussais Hospital, 31 of which were requested and carried out as emergency procedures by day or night, 187 pre- or postoperatively and 79 in the out-patient clinic. M mode and 2D echocardiographies were performed at the bedside when necessary, namely in the intensive care unit pre- and postoperatively. The examination was performed by trained personnel, both in the out-patient clinic and in the intensive care unit. In the 31 cases in which the examination was requested as an emergency, the information obtained practically always contributed to establishing the right diagnosis and to correct therapeutic intervention. In 24 cases, the emergency occurred in the post-operative period: 18 cases of cardiac failure, of which echocardiography contributed to the indication of reoperation in 4 cases, the contra-indication of reoperation in 11 cases, and the need for emergency catheter studies in 2 cases. In one case the examination was unnecessary. In 6 other cases, suspected intracardiac thrombosis was excluded. There were 7 requests for emergency echocardiography in the preoperative period and the information obtained contributed to the indication for emergency surgery in 3 cases, and guided the operative strategy. The need for urgent surgery was refuted in 3 cases. The examination was unnecessary in 1 case. The results of echocardiography were very reliable. It does not seem to have provided any misleading information; the examination was incomplete in only 10% of cases.(ABSTRACT TRUNCATED AT 250 WORDS)
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It is well-known that cirrhosis is a predisposing factor to Yersinia septicemia. This study includes 73 cirrhotics and shows a high number of positive serologic tests (47/73 : 64.4%). However, there is no correlation with clinical features or bacteriological findings. The most frequent serotypes, i.e. pseudotuberculosis IV and enterocolitica 0:9, differ from those which are usually found in Yersinia septicemias. Iron overload in cirrhosis, increased intestinal load of gram-negative bacilli and possible latent bacteremia may partly explain these results. However, the role probably played by as yet poorly known cross-reactions between Yersinia and other pathogens (Shigella, E. Coli...) must be underscored. The authors conclude that slightly positive, stable, serodiagnostic tests have little meaning in cirrhotics.
Four cases of hepatic granulomatosis with positive Yersinia serologic tests are reported. In one case, the Wright serodiagnostic tests were also positive. In the three other cases, no other likely etiology was demonstrated. The authors recall the main causes of hepatic granulomatosis, diagnostic criteria of Yersiniosis infections, and the possible occurrence of simultaneous positive serodiagnostic tests for Yersinia enterocolitica type 9 and Brucella abortus.
A case of Reiter disease in a HLA B27 positive man with urethritis followed by polyarthritis is reported. During the disease, serologic conversion for Yersinia enterocolitica type 9 was detected as well as positive serologic tests for Shigella flexneri and Chlamydia. The features of reactive arthritis related to Yersinia and the etiologies of Reiter disease are recalled.
The authors report two studies : 1) Retrospective : study of liver biopsies in 44 Africans : 22 were HBs Ag positive and 22 HBs Ag negative ; 10 of the HBs Ag positive subjects were found to have chronic persistent hepatitis (CPH), 4 chronic active hepatitis (CAH) and 3 cirrhosis ; 2 of the HBs Ag negative subjects were found to have CPH and 3 CAH ; as far a biological findings are concerned, only the CAH and cirrhosis groups differed from the control group, with higher prothrombin times, transaminase levels and gammaglobulin levels. 2) Prospective : study of the incidence of HBs Ag carriage in 168 Africans ; 17.8 % of them were found to be carriers ; no correlation was found between HBs Ag carriage and S. haematobium schistosomiasis or hemoglobinopathies.
A case of angiocholitis with polymicrobic septicemia in an 85-year-old man with a history of cholecystectomy and choledocho-duodenal anastomosis is reported. The biliary tract was obstructed by a piece of tomato skin. Antibiotherapy and fibroscopic extraction of the skin ensured recovery. The authors recall the low incidence of polymicrobic septicemias, diagnostic criteria, promoting factors, poor prognosis, and the responsibility of digestive reflux and above all of stasis and high pressure in angiocholitis and septicemia following biliodigestive anastomosis.
Cardiac localizations in hydatid disease are uncommon and often latent. A mass at the apex of the heart was discovered in a 42-year-old patient who presented with abnormal EKG repolarization. This mass was anechoic. Coronography demonstrated an avascular lesion with displaced coronary arteries. A hydatid cyst was suspected. No other visceral localizations of hydatid disease were detected. The patient refused surgery and was seen two years later with acute pericarditis and rapidly developing cardiac tamponade. A very large amount of pericardial fluid and a single hydatid cyst were discovered upon surgery. The cyst was aspirated and sterilized and the protruding cyst wall was resected. A severe postpericardotomy syndrome and positivation of hydatid disease serological tests occurred during the postoperative course. The patient was then given flubendazole. Prompt recovery occurred and the patient is still doing well under therapy two years later. In hydatid disease, an isolated cardiac localization is uncommon and often latent and may be revealed by complications. Prompt diagnosis should be made by echocardiography.
A lymphography was performed as a diagnostic procedure in a 69-year-old female patient hospitalized for protracted fever. Akinetic mutism with left hemiparesis occurred 10 minutes after the injection of ultrafluid lipiodol. The patient died 13 days later. Neurologic complications of lymphography are extremely rare but may be life-threatening. Speculations as to the mechanisms which may be responsible for these complications, through a modification of the usual distribution of the contrast media, include lymphovenous shunts, lymphatic vessel compression or obstruction, pulmonary arteriovenous shunts and right-to-left intracardiac shunts. These mechanisms may facilitate cerebral embolization of the contrast media. Indications of lymphography must be restricted in patients with patent lymphatic obstruction.