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Biomedical subjects

M Grinberg

Publications and source records attributed to M Grinberg.

At least 199 records · Page 11Linked to original sources

Obstetric and perinatal aspects in patients with congenital heart diseases.

The benefits of surgical treatment for patients with congenital heart disease in relation to pregnancy are still controversial. We studied 48 pregnant women (mean age = 25 years) with surgically-corrected congenital heart diseases (Group 1). This included 15 cyanotic diseases: Fallot's tetralogy (11 cases); Ebstein's anomaly (2 cases); transposition of the great arteries (1 case); and double outlet of the right ventricle (1 case). We compared them to 52 pregnant women (mean age = 26 years) with untreated congenital heart diseases, which included 11 cases of Eisenmenger's syndrome (Group 2). Group 2 showed a higher incidence of maternal death (12 vs. 0 percent; p = 0.01), perinatal mortality (15 vs. 0 percent; p = 0.01) and prematurity (32 vs. 7 percent; p = 0.01). Spontaneous abortion (4 vs. 10 percent), Caesarean deliveries (48 vs. 66 percent) or growth retardation (13 vs. 28 percent) did not present any significant differences between these groups. Surgical treatment in patients with heart diseases is associated with a better maternal and fetal prognosis. Therefore, surgery must be considered when counseling patients with congenital heart diseases.

Abortion, Spontaneous↗

[Course of pregnancy and puerperium in women with mitral valve stenosis].

PURPOSE: To study pregnancy, delivery, puerperium and the newborn in cases of mitral valve stenosis, asymptomatic at conception. METHOD: Sixty-two pregnant women, 30 with mitral valve stenosis (GE group) and 32 without cardiac disease (GN group) had their functional class, kind of delivery, anesthetic technique and newborn characteristics evaluated during gestation. RESULTS: In GE group 16 (53.3%) patients changed from functional class (FC) I/II to FC III and 10 (33.3%) to FC IV. In GN group 18 (56.2%) changed from FC I to II during the gestation. Delivery was vaginal in 21 patients (70%); anesthetic technique was regional block in 17 (56.6%). These findings were not statistically different between (p > 0.1) the groups. Premature (20.0%) and small babies for gestational age (36.7%) were higher (p > 0.001) in GE group. There were no cases of maternal death. CONCLUSION: The majority of GE women who started pregnancy in FC I/II changed to FC III/IV during gestation. Probably adequate medical treatment and valvoplasty in one case allowed fetal viability; but we had higher incidence of pre-term and small for gestation age babies in the GE group.

Adolescent↗

Mycotic aneurysm of the celiac trunk and superior mesenteric artery in a case of infective endocarditis.

Mycotic aneurysms of the celiac artery are extremely rare, and in our review of the literature we found that in only one case was it due to infective endocarditis. In our case a 19-year-old female patient with culture-negative infective endocarditis presented with pain in the epigastric area. A celiac artery aneurysm was diagnosed by ultrasonography and confirmed on CT scan and angiography, which also demonstrated an associated aneurysm of the superior mesenteric artery. Since excellent collateral circulation was present, simple ligation of the two aneurysms was performed. The patient presented no major complications in the postoperative course.

Adult↗

Calcific aortic stenosis presenting as acute myocardial infarction.

A previously asymptomatic 38-year-old male with calcific aortic valve stenosis (instantaneous peak-to-peak systolic gradient: 46 mmHg) suffered an acute myocardial infarction. Coronary arteriography revealed an obstruction in a distal branch of the left circumflex artery. Left ventricular angiography demonstrated impairment of contraction of the lateral wall. We suggest that the myocardial infarction was the result of calcific embolism from the calcified aortic valve stenosis and may occur as a first manifestation of the disease.

Adult↗