Search PubMed⌕ Search

Biomedical subjects

M Grellet

Publications and source records attributed to M Grellet.

At least 19 recordsLinked to original sources

Adaptive estimation of residue signal for voice pathology diagnosis.

The use of noninvasive techniques to evaluate the larynx and vocal tract helps the speech specialists to perform accurate diagnose of diseases. In this study, a method to distinguish among 21 different pathologies using speech signals was developed. Through inverse filtering (Kalman and Wiener filters) of the voice signal, the residue was estimated and seven acoustic features were extracted from it to evaluate the laryngeal diseases. As time-invariant inverse filtering was used, the nonstationary nature of dysphonic voices was also considered. Together with the estimation of the acoustic features using a robust statistical method, this technique also allowed us to discriminate among pathologies with very close perceptual characteristics. The results from a Mann-Whitney test indicated that the best measurement for pathological discrimination was JITTER with 54.79% ability to cluster the voice types and the worst one was spectral flatness of residue (SFR) with 36.41%.

Acoustics↗

[Diagnostic procedure in chronic cervicofacial adenopathies].

Results of clinical examination are fundamental for establishment of an etiologic diagnosis, but the additional data provided by paraclinical investigations are essential elements. Adenectomy should be performed when etiology is uncertain.

Chancre↗

[Initial polychemotherapy in the treatment of cancers of the head and neck. The efficacy and tolerance of 2 nonrandomized combinations in 48 patients].

Before loco regional treatment for head and neck cancer forty eight patients received one or the other of the following combined chemotherapy regimens: Regimen A (28 patients): high dosage methotrexate, bleomycin, cis-platin; regimen B (20 patients): common dosage methotrexate, bleomycin, hydroxyurea, vincristin. The effectiveness of regimen A seemed better than that of regimen B (46% responses versus 20%). This assessment must be accepted with caution, since, although the organization of treatment was strictly similar in the two groups, the study was not randomized, and there were noticeable differences between the two groups. Regimen B was associated with no toxicity. Regimen A was responsible for two fatalities. These two cases were linked to high dosage methotrexate. However, a combined chemotherapy regimen of type A with the high dosage methotrexate replaced by intermediate dosage methotrexate, seems feasible to us. Loco regional treatment was not impaired by initial chemotherapy with either regimen.

Antineoplastic Combined Chemotherapy Protocols↗

[Mucopolysaccharidosis].

The different types of mucopolysaccharidosis, due to a congenital absence of a lysosomial dehydrolysase acid, are the origin of facial deformities. Precise diagnosis depends on the results of biochemical and histological examinations.

Facial Asymmetry↗

[Nerve and artery lesions after irradiation (author's transl)].

Recent studies relating to soft tissue lesions following irradiation have been concerned with those involving nerves and arteries: Nerve root myelopathies--Brown-sequard's syndrome--spasmodic paraparesis Peripheral neuropathies--plexal disorders--peripheral lesions Carotid stenosis.

Arterial Occlusive Diseases↗

[Twenty-five cases of bone resection for mandibular osteoradionecrosis (author's transl)].

Good morphological and functional results are obtained in lateral osteoradionecrosis after bone resection by the endobuccal route, and this operation should be performed at an earlier stage. Median resections give poor results and in these cases it is reasonable to temporize in the normal manner. Long-term prognosis is only moderate as tumoral recurrences are frequent in these patients.

Humans↗

[Tricho-rhino-phalangeal syndrome (author's transl)].

Tricho-rhino-phalangeal syndrome, of genetic origin, consists invariably of an association of finger malformations, changes in the hair system and nasal malformations. There may also be other facial abnormalities. Plastic surgery may improve the appearance of these subjects.

Abnormalities, Multiple↗