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Biomedical subjects

M Grandolfo

Publications and source records attributed to M Grandolfo.

At least 55 records · Page 3Linked to original sources
PubMed1990

Serum-induced cytosolic calcium movements and mitogenesis in cultured preosseous chondrocytes.

The differentiation of preosseous chondrocytes begins with the proliferation of resting cells and results in the expression of the hypertrophic phenotype. The effect of fetal calf serum on chondrocyte mitogenesis and intracellular Ca2+ concentration was studied in resting and hypertrophic cells in primary culture. Resting chondrocytes respond to the growth stimulus with immediate release of Ca2+ from intracellular stores and with opening of the plasma membrane Ca2+ channels. These events may be related to the elevated [3H]thymidine incorporation observed after serum exposure. In contrast, in hypertrophic chondrocytes the lower rate of DNA synthesis seems to be coupled with a lower activity of the Ca2+ signaling mechanism and, probably, with reduced intracellular calcium stores. It is proposed that expression of the Ca2+ signaling mechanism may be modulated during the differentiation of preosseous chondrocytes.

Animals↗
PubMed1986

A health examination of railway high-voltage substation workers exposed to ELF electromagnetic fields.

This is a cross-sectional survey on the health conditions of railways workers active in 258 interconnection and conversion substations all over Italy. Measurements performed in both kinds of substations operating at 220 kV have shown that maximum levels of the electric field strength and of the magnetic flux density at 50 Hz are of the order of 5 kV/m and 15 microT, respectively. Three subject groups, differently exposed (1, 10, 20 h/week), and an unexposed control group, for a total number of 627 workers, constitute the population at study. All subjects underwent a general medical examination, laboratory investigations, and a series of selected examinations relative to three systems (nervous, cardiovascular, and haematopoietic) considered at higher risk. No differences have been found between the exposed and the control groups. It is concluded that workers exposed to ELF electromagnetic fields of moderate strength do not show the presence of clear effects on their state of health.

Electromagnetic Fields↗
PubMedDate not supplied

[National and international standards for limiting exposure to electromagnetic fields].

Over recent years the possibility that adverse effects on health could result from exposure to electromagnetic fields has become one of considerable scientific, political and economic importance. In response to this, there has been intense activity, both at the international and national level, on the evaluation of biological effects literature and assessment of health hazards of human exposure to non-ionizing electromagnetic radiation. The health authorities of an increasing number of countries, including Italy, become involved in the development of recommendations, regulations or technical advice to limit the exposure of the workers and the general public and they are looking to the international organizations, particularly to the International Commission on Non-Ionizing Radiation Protection (ICNIRP), for some guidance in this respect. In this paper an attempt will be made to present a comparative analysis of the existing or recently proposed standards.

Electromagnetic Fields↗