Mike Grace talks to Tony Kilcoyne. Interview with the editor.
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Awards and Prizes↗
Biomedical subjects
M Grace
Publications and source records attributed to M Grace.
Paradigm busters.
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Attitude of Health Personnel↗
Randomised double-blind placebo-controlled study on adverse effects of rubella immunisation in seronegative women.
BACKGROUND: The objective of our study was to investigate the association of adverse clinical musculoskeletal and neurological events in healthy postpartum women with live attenuated (RA27/3 strain) rubella-virus vaccine, and to assess the frequency of acute and recurrent arthralgia and arthritis and associations with acute and recurrent muscle pain (myalgia) and neurological manifestations (paraesthesias). METHODS: We used a randomised placebo-controlled, double-blind design in a community setting. 636 women were enrolled and, after 90 women dropped out, 546 healthy women aged 18-41 years, who were rubella seronegative on routine screening were immunised parenterally with either monovalent live attenuated (RA27/3 strain) rubella vaccine (n = 270) or saline placebo (n = 276) in the postpartum period. Outcome measures were the occurrence of acute and persistent or recurrent joint manifestations (arthralgia or arthritis) at 1, 3, 6, 9, and 12 months after immunisation. Occurrence of muscle pain (myalgia), and neurological symptoms (paraesthesia) was also assessed at the same times. FINDINGS: 543 women completed 1-month follow-up. 456 women completed the 12-month assessment. There were no differences at the time of immunisation between rubella vaccine and placebo groups in distribution of age, ethnic origin, parity, time between delivery and immunisation, breastfeeding history, or histories of earlier rubella vaccination or joint complaints. Results indicated a significantly higher incidence (p = 0.006; odds ratio = 1.73 [95% CI = 1.17-2.57]) of acute joint manifestations in rubella-vaccine recipients (30%) than in placebo recipients (20%). Frequency of chronic (recurrent) arthralgia or arthritis was only marginally significant (p = 0.042; 1.58 [1.01-2.45]). INTERPRETATION: RA27/3 rubella vaccine given to seronegative women during the postpartum period was significantly associated with development of acute arthralgia or arthritis. Although the numbers of women assessed and length of follow-up revealed only marginally significant differences in persistent or recurrent joint manifestations between rubella vaccine and placebo recipients, it is possible that susceptible women who are given rubella vaccination may experience this outcome.
Adolescent↗
Patient focus.
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Appointments and Schedules↗
Should we give them what they want?
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Health Services Needs and Demand↗
The carboxyl-terminal zinc-binding domain of the human papillomavirus E7 protein can be functionally replaced by the homologous sequences of the E6 protein.
The carboxyl-terminus is necessary for the functional and structural integrity of the human papillomavirus (HPV) E7 oncoprotein. Since many mutations in this domain of E7 result in the formation of unstable proteins, we have evaluated the importance of this region by replacing it with structurally related domains derived from HPV E6 proteins. Biological analysis of these mutant chimeric E7/E6 proteins showed that they retained E7-specific biological activities including cooperation with the ras oncogene to transform primary baby rat kidney cells and transcriptional activation of an E2F responsive reporter plasmid. One of the chimeric proteins was impaired in its ability to physically disrupt pRB/E2F complexes in vitro suggesting that there are defined molecular determinants in the carboxyl-terminus of E7 for this activity. In contrast, none of these proteins exhibited E6-like properties including binding to p53 and/or degradation of associated proteins.
Amino Acid Sequence↗
Mechanical and electrothermal debonding: effect on ceramic veneers and dental pulp.
This study compared the ability of three orthodontic debonding techniques for the removal of brackets from ceramic veneers without creating veneer damage. Three experimental groups included metal brackets debonded by either Howe pliers, lift off debonding instrument (LODI, 3M Unitek), or electrothermal debonder (ETD, "A" Company), as well as a group of electrothermally debonded ceramic brackets. It also evaluated and compared the intrapulpal temperature changes produced by electrothermal debonding metal and ceramic brackets. A sample of 95 extracted maxillary first premolars were prepared and restored with Mirage ceramic veneers (Chameleon Dental Products, Inc.). Veneer buccal surfaces were treated with 2.5% hydrofluoric acid, before silane application and bracket bonding with a no-mix resin. Specimens were thermocycled before debonding. All debonded specimens were examined under x20 magnification for veneer damage. A thermocouple was positioned at the pulp chamber buccal wall to record temperature increases (due to ETD activation) through a digital thermometer. Results suggest that ETD provides predictable debonding to ceramic brackets with no veneer damage and minimal risk to the pulp. Removal of metal brackets through electrothermal debonding produced ceramic damage in 13% of cases, and elevated temperatures beyond the threshold of irreversible pulpal damage (5.5 degrees C) in 46% of cases. Howe plier and LODI bracket removal are associated with ceramic damage incidence of 21% and 35%, respectively.
Analysis of Variance↗
TMJ internal derangement and adolescent craniofacial morphology: a pilot study.
Intrinsic and extrinsic factors influence the growth of mandibular condylar cartilage. Local environmental factors, such as temporomandibular disc displacement, may alter condylar cartilage growth resulting in facial changes. The aim of this study was to determine if there was an association between identifiable altered craniofacial morphology and disc displacement. Magnetic resonance imaging (MRI) was employed to determine disc position in 25 preorthodontic adolescent patients (mean age 12.8 years, range 10 to 17 years). Magnetic resonance imaging and lateral cephalometric radiography were performed with the teeth held in centric occlusion by means of a polyvinylsiloxane bite registration. Radiographs were traced and variability between tracings within patients was insignificant for all variables (p > 0.04) except Co-Go, S-Go, and SN/Go-Me (p < 0.01). For each patient, 10 linear, 4 angular, and 3 ratio measurements were compared with an age- and sex-matched population in the Craniofacial Growth Series. Multiple regression analysis showed positive and negative associations between disc displacement and cephalometric variables. R-square value was .91 for the left TMJ and .82 for the right. Disc displacement in an adolescent population may be associated with altered craniofacial morphology.
Adolescent↗
NHS or private--a balanced choice.
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Attitude of Health Personnel↗
Re-certification.
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Education, Dental, Continuing↗
Rights and responsibilities.
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Health Services Accessibility↗
Who's representing whom?
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Dental Auxiliaries↗