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Biomedical subjects

M Grace

Publications and source records attributed to M Grace.

At least 307 records · Page 17Linked to original sources
PubMed1973

Effects of chronic hemodialysis on thyroid function in chronic renal failure.

Thyroid function was studied in 54 patients undergoing chronic hemodialysis. Serum thyroxine, triiodothyronine and free thyroxine and the free thyroxine index were significantly lower than normal. The levels of both serum thyroxine and the free thyroxine index tended to fall progressively the longer the patients were on hemodialysis. These findings, in association with low serum TSH levels and normal increase in radioactive iodine uptake by the thyroid after TSH injection, suggest that a defect in pituitary secretion of TSH may be responsible. Although some patients experienced symptomatic improvement after treatment with L-thyroxine the efficacy of this form of treatment in patients on chronic hemodialysis has not yet been established.

Adolescent↗
PubMed1968

Dysbarism: osmosis caused by dissolved gas?

The pressure in an osmometer, filled with nitrous oxide-saturated water separated from water by a polyurethane polyether membrane 2.5 microns in thickness, rose slowly by 8 to 20 millimeters (of water) in 10 minutes before gradually returning to close to zero within 2 hours. The permeation coefficient of the membrane was approximately 1000 times greater for water than for gases. The osmotic pressure of water saturated with nitrous oxide at 1 atmosphere, derived from the freezing point of the gas solution, was 1.5 atmospheres. It is concluded that dissolved gases exert osmotic pressure. Partial-pressure gradients of dissolved gases in the tissues of animals and man should cause flows of water along osmotic gradients, which may partially account for some of the symptoms and signs of dysbarism.

Decompression Sickness↗
PubMedDate not supplied

Neuropeptides and thermoregulation: the interactions of bombesin, neurotensin, TRH, somatostatin, naloxone and prostaglandins.

In this study we have examined the interactions of bombesin (1 microgram ICV), neurotensin (1 microgram ICV), TRH (10 micrograms ICV), somatostatin (10 micrograms ICV), PGE2 (10 micrograms ICV) and naloxone (10 mg/kg SC) on thermoregulation in the rat at room temperature (20 +/- 1 degree C). Given alone, bombesin, neurotensin, somatostatin and naloxone all produced hypothermia (bombesin greater than neurotensin greater than somatostatin congruent to naloxone). PGE2 was hyperthermic, and TRH had no effect. Bombesin and PGE2 neutralized one another's effects. Neurotensin had no effect on PGE2-induced hyperthermia. Naloxone enhanced the hypothermic effect of bombesin and somatostatin enhanced the rate of onset of hypothermia after bombesin. TRH had no effect on bombesin-induced hypothermia. TRH, somatostatin and naloxone had no effect on neurotensin-induced hypothermia. TRH antagonized the hypothermia due to naloxone and somatostatin.

Animals↗
PubMedDate not supplied

Attitudes and practices of pharmacy managers regarding needle sales to injection drug users.

OBJECTIVE: To determine Louisiana pharmacy managers' attitudes and practices regarding needle and syringe sales to suspected injection drug users (IDUs) without prescriptions, and to assess which factors affect their decisions to sell nonprescription needles and syringes. DESIGN: Cross-sectional mail survey. SETTING: The six most populous cities of Louisiana. PARTICIPANTS: Pharmacy managers with active permits not affiliated with large hospitals or institutions. MAIN OUTCOME MEASURES: Selling nonprescription needles to suspected IDUs, willingness to sell nonprescription needles to suspected IDUs, and reasons for not selling nonprescription needles to suspected IDUs. RESULTS: Approximately one-fourth of the respondents reported that they had sold needles and syringes to suspected IDUs without a prescription. The most frequently cited reason for not selling was fear of increasing drug use; however, many of these pharmacists reported that they would conduct a sale if the customer had a referral from an agency or clinic. CONCLUSION: Pharmacists can assist in the prevention of HIV transmission through nonprescription needle sales to IDUs. This role can be promoted through education of pharmacists and development of referral systems for IDUs.

Adult↗
PubMedDate not supplied

Biological thermal detection: micromechanical and microthermal properties of biological infrared receptors.

Bioinspired design of biomimetic sensors relies upon the complete understanding of properties and functioning of biological analogues in conjunction with an understanding of their microstructural organization at various length scales. In the spirit of this approach, the microscopic properties of infrared (IR) receptors of snakes with "infrared vision" were studied with scanning thermal microscopy and micromechanical analysis. Low surface thermal conductivity of 0.11 W/(m K) was measured for the IR receptor surfaces as compared to the nonspecific skin areas. This difference in surface thermal conductivity should result in a significant local temperature gradient around the receptor areas. Micromechanical analysis showed that pit organs were more compliant than surrounding skin areas with an elastic modulus close to 40 MPa. In addition, the maximum elastic modulus was detected for the outermost layer with gradually reduced elastic resistance for the interior. The porous microstructure of the underlying tissue combined with the highly branched microfibrillar network (Biomacromolecules 2001, 2, 757) is thought to be responsible for such a combination of biomaterial properties. Considering these biomaterials features, we postulated a possible design of an artificial photothermal detector inspired by the microstructure of natural receptors. This bioinspired design would include a microfabricated cavity filled with an ordered lattice of microspheres with a gradient periodicity from the surface to the interior. Such a "photonic cavity" could provide an opportunity for multiple scattering at wavelength tuned to 8-12 microm as a range of highest sensitivity.

Animals↗
PubMedDate not supplied

Who is in control?

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Health Education, Dental↗
PubMedDate not supplied

The continuing saga.

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Fluoridation↗
PubMedDate not supplied

Fraud in dentistry.

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Dental Health Services↗
PubMedDate not supplied

The big issue.

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Attitude of Health Personnel↗
PubMedDate not supplied

Relationship of turnout to hip abduction in professional ballet dancers.

The ability to externally rotate or turn out the hip is fundamental to ballet. Every classical dancer aims to achieve perfect turnout. The purpose of this study was to determine how much turnout is necessary for maximal abduction. It was hypothesized that moderate turnout is sufficient for this purpose. Twenty-two professional dancers from the Alberta Ballet Company were studied. Measurements of passive hip abduction were taken at 0 degree, 45 degrees, 60 degrees, 70 degrees, 80 degrees, 90 degrees and maximum hip lateral rotation using a goniometer and Leighton flexometer. Statistical analysis was done using Pearson correlation coefficients. A significant positive correlation was found between abduction and lateral rotation (P less than 0.05). The greater the position of external rotation, the more abduction achieved. In conclusion, the traditional emphasis on good turnout has some scientific merit and functional implications.

Adult↗
PubMedDate not supplied

Measuring long-term outcome after traumatic brain injury.

We report the results of the first stage of development of an instrument to measure long-term functional outcome after traumatic brain injury. The instrument focuses on both the person with a disability and the impact on the family caregiver. We illustrate the early stages of instrument development, focusing on one approach to standardized reviewer feedback to evaluate content validity. The results of the pilot testing are discussed in terms of: purpose, instrument construction, and clinical utility. While the complete details of the instrument are not presented, example items are used as illustration. A number of methodological issues in instrument development in rehabilitation are described including the logistics of reviewer feedback, the use of family caregivers in instrument development and the reliability of self-report in brain-injured population.

Activities of Daily Living↗