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Biomedical subjects

M Gorsky

Publications and source records attributed to M Gorsky.

At least 55 records · Page 3Linked to original sources

The retrocuspid papillae in Israeli Jews.

The prevalence of an anatomic variation, called retrocuspid papilla, was determined in Israeli Jews. The distribution of the retrocuspid papillae, according to two age groups, and symmetry within the dental arch and in relation to ethnic origin were examined. Results showed that retrocuspid papillae were observed in 38.5% of the young group and in 11.3% of the adult group. Greater occurrence of bilateral than unilateral retrocuspid papillae was observed in each age group and in both sexes. No significant ethnic trend was found when the prevalence of retrocuspid papillae was examined in relation to the ethnic origin of the study sample.

Adolescent↗

Oral mucous membrane pemphigoid. A study of sixty-five patients.

Sixty-five patients with oral mucous membrane pemphigoid were examined, treated, and followed for a mean of 3.5 years. Seventy-two percent were women, and the mean age was 59 years. In most patients multiple oral sites were involved and the gingiva was affected in 94% of the patients. Seven patients had ocular lesions (symblepharon), and seven others had nasal, vaginal, or pharyngeal involvement. Persons with skin lesions (bullous form) were not included in this series. Topical and systemic anti-inflammatory/immunosuppressive medications were successful in controlling signs and symptoms. There were no spontaneous remissions. Candidiasis, tobacco, other diseases, and drugs did not appear to be related to the pemphigoid.

Adult↗

Fordyce's granules in the oral mucosa of adult Israeli Jews.

The prevalence of Fordyce's granules in a group of 2,462 Israeli Jews was determined. Fordyce's granules were observed in 94.9% of the entire sample. The most common location was the vermilion border of the upper lip (82.2%), followed by the retromolar area (73.3%), the buccal mucosa (65.9%) and the vermilion border of the lower lip (29.2%). The granules were common in men. A significant difference in prevalence was found between the Ashkenazi group and each of the other two ethnic groups.

Adolescent↗

A prospective follow-up study of 570 patients with oral lichen planus: persistence, remission, and malignant association.

Five hundred seventy patients with oral lichen planus were followed for periods ranging from 6 months to more than 10 years (mean, 5.6 years). The mean age was 52 years, and 67% of the patients were women. Erosive lichen planus was the most frequent clinical form, and the buccal mucosa was the most common site. Of the 75% patients treated with corticosteroids, 29% experienced complete remission and 63% had partial remission while maintained on medication. Fewer than 3% experienced spontaneous remission. Malignant transformation occurred in 7 patients (1.2%) in a mean time of 3.4 years after the onset of lichen planus. The onset of lichen planus could not be associated with any evident factors, such as family history, Candida albicans, glucose intolerance, and smoking.

Adolescent↗

Commissural lip pits in Israeli Jews of different ethnic origin.

The prevalence of commissural lip pits in a group of 2462 Israeli Jews was determined, and a relation of commissural lip pits to ethnic background was noted. Results showed the presence of commissural lip pits in 17.4% of the entire sample; 9.7% were unilateral and 7.7% were bilaterally located. The Ashkenazi group showed a significant higher prevalence of commissural lip pits (19.4%) when compared to the prevalence in the Sephardic group (14.1%) and the Eastern group (21.1%).

Adolescent↗

Oral leukoplakia and malignant transformation. A follow-up study of 257 patients.

Two hundred fifty-seven patients with oral leukoplakia were studied and followed for an average period of 7.2 years. All lesions were more than one cm in size and had been present and observed for a minimum of 6 months. Of the initial biopsies, 235 revealed a benign hyperkeratosis and 22 others contained some degree of epithelial dysplasia. Seventy-three percent of the patients used tobacco, with cigarette usage being the predominant form. Forty-five patients (17.5%) subsequently developed squamous carcinomas in the hyperkeratotic epithelial site in an average time of 8.1 years. Eight of these malignant transformations came from patients who originally had epithelial dysplasia. High risks for malignant transformation also included non-smoking patients, the clinical presence of erythroplasia (erythroleukoplakia), and a clinical verrucous-papillary hyperkeratotic pattern. Duration of the leukoplakia progressively increased the total number of malignant transformations, with the largest rate occurring in the second year. This study confirms that oral leukoplakia is a precancerous lesion and that certain characteristics indicate greater risks and warrant consideration of more aggressive management.

Adult↗

Denture wearing and oral cancer.

Four hundred patients with oral cancer were studied to determine if there appeared to be a risk related to denture wearing. Forty-three percent of the group wore dentures, and there seemed to be no correlation between the wearing of dentures and any specific cancer site. Furthermore, there was no difference between denture and nondenture wearers relative to age, sex, time from first signs or symptoms to diagnosis, tumor stage, or tobacco use. In addition, a large number of individuals in the general population wear dentures, and carcinomas occur infrequently in denture-bearing sites. Other studies have shown no difference between denture wearers and control groups in the occurrence of oral cancer. Therefore, it does not seem plausable at this time to consider denture irritation as a significant carcinogenic aggravating factor.

Adolescent↗

Physiologic pigmentation of the gingiva in Israeli Jews of different ethnic origin.

The prevalence of gingival physiologic pigmentation in three ethnic groups of a total of 2,465 Israeli Jews were determined. The distribution of this gingival pigmentation, according to anatomic parts and divisions, was examined. Results showed the presence of gingival pigmentation in 57.9% of the Eastern group, 49.3% of the Sephardic group, and 21.1% of the Ashkenazi group. No indication of sex predilection was found. The most common site of pigmentation was the labial part of the gingiva, and the attached gingiva was the most common pigmented anatomic division. The group of Eastern Jews showed the highest prevalence of physiologic pigmentation in each of the anatomic parts and divisions of the gingiva.

Adolescent↗

Physiologic pigmentation of the oral mucosa in Israeli Jews of different ethnic origin.

The prevalence of oral physiologic pigmentation in three ethnic groups of a total of 2465 Israeli Jews was determined, and the relationship of oral pigmentation to age and sex within the groups was noted. Results showed the presence of oral pigmentation in 63.6% of the Eastern group, 54.8% of the Sephardic group, and 24.9% of the Ashkenazi group. No indication was found of sex predilection, and no significant trend was evident in the prevalence of pigmentation with relation to age. The leading site of pigmentation among the entire sample was the gingiva, and this finding did not vary with ethnicity.

Adolescent↗

Histiocytosis X: occurrence and oral involvement in six adolescent and adult patients.

Six cases of adolescent- and adult-onset histiocytosis X with oral involvement and their evaluation are described. Clinical findings can be mistaken for dental infection. Management involved a combination of low-dose radiation and chemotherapeutic drugs. The extreme variability of clinical signs and symptoms and the extent and progression of the disease suggest that the classic classification of histiocytosis X is inappropriate.

Adolescent↗

Metastatic chordoma to the mandible.

The chordoma is a slowly growing spinal cord tumor that rarely metastasizes. This is the first report in the literature of a chordoma with metastasis to the mandible. The mandibular involvement occurred 4 years after the primary sacral chordoma was controlled by excision and radiation. The jaw lesion did not respond to radiation but has been controlled by resection.

Chordoma↗

Tobacco usage in patients with head and neck carcinomas: a follow-up study on habit changes and second primary oral/oropharyngeal cancers.

One hundred and sixty patients with head and neck carcinomas were followed from one to 15 years to assess the associations between tobacco usage and the development of multiple head and neck cancers. Seventy-three percent had tobacco habits, with nine of ten users smoking cigarettes. In almost one in five patients (18.1%), second primary oral/oropharyngeal cancers developed in a mean time of five years. Those who did not change their original tobacco habits incurred the greatest risk, as a second primary cancer developed in 30%. Reducing or discontinuing smoking appeared to have a beneficial effect. There was also an increased risk for multiple cancers in males, probably because of their larger amount of daily smoking.

Adult↗

Gustafson's method for age determination from teeth--a modification for the use of dentists in identification teams.

Gustafson's method for age determination from teeth is based on the evaluation of ground sections of teeth. Six age-associated parameters are evaluated in the ground section and are compared to a regression curve of age versus the age-associated changes. Two of these changes, transparency of radicular dentin and secondary dentin, have the highest correlation with age. The evaluation of these parameters only from thin (0.25-mm) ground sections may lead to an artificially high "secondary dentin value." These artifacts may be caused by the attempt to include the whole pulp chamber and root canal in a 0.25-mm-thick ground section and by an accidental overgrinding of the apical area of the root, respectively. These artifacts were encountered occasionally even in ground sections prepared by highly trained personnel and became more frequent in ground sections prepared by a person who, though trained, did not use this technique daily. A modification of the data-collecting method is suggested to make possible the use of thick (1.0-mm) ground sections for the evaluation of most of the aging criteria, thereby eliminating the possible inaccuracies in the preparation and evaluation of the thin (0.25-mm) ground sections.

Age Determination by Teeth↗