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Biomedical subjects

M Golimbu

Publications and source records attributed to M Golimbu.

At least 37 records · Page 2Linked to original sources
PubMed1985

Value of scrotal scanning. Report of 62 cases.

A review of sixty-two technetium scrotal scans performed over a one-year period has led to a classification of pathologic states based on the degree of uptake of the radioactive isotope. Absent uptake, or a "cold" scan, is present only with testicular torsion, and rarely with avascular tumors. Increased uptake, or a "hot" scan, is most commonly seen with inflammatory conditions such as acute epididymitis and orchitis, and less commonly with tumor. "Mixed" scans can be associated with abscess, tumor with necrosis, trauma, and late torsion.

Epididymitis↗
PubMed1984

A syndrome of gonadotropin resistance possibly due to a luteinizing hormone receptor defect.

An 18-yr-old 46,XY man with primary hypogonadism and a microphallus is described whose Leydig cells appear to be partially insensitive to gonadotropin action. The external genitalia were well differentiated though abnormally small. The mean +/- SE baseline plasma testosterone (T) level was 62 +/- 3.9 ng/dl, and androstenedione was 34.5 +/- 7.3 ng/dl. Plasma levels of dehydroepiandrosterone, dehydroepiandrosterone sulfate, 17-hydroxyprogesterone, 17-hydroxypregnenolone, corticosterone, deoxycorticosterone, and 17 beta-estradiol were all normal. After the im administration of hCG, plasma T increased insignificantly from 71 to 78 ng/dl, and androstenedione increased from 22 to 47 ng/dl; there was no significant change in the levels of precursor steroids. The mean +/- SE serum FSH level was 17.4 +/- 3.6 mIU/ml, and LH was 15.4 +/- 1.1 mIU/ml (normal, 5-20); both responded briskly to iv GnRH. Exogenous T therapy resulted in normal virilization, whereas therapy with hCG was ineffectual. Testicular biopsy revealed Leydig cells in normal numbers, some spermatogenesis, and thickened tubular basement membranes. In vitro binding studies using [125I]hCG were performed with testicular homogenates from the patient and three normal subjects. With 7.4 fmol labeled hCG, the specific binding (mean +/- SD), expressed as femtomoles of hCG per mg protein, was 1.16 +/- 0.44 compared to 2.49 +/- 0.41 in normal subjects (P less than 0.05). These data demonstrate partial resistance to hCG and suggest that the defect in Leydig cell function may be at the LH receptor or postreceptor level.

Adolescent↗
PubMed1981

CAT scanning in staging of prostatic cancer.

Forty-six patients with histologically proved adenocarcinoma of the prostate underwent pelvic lymphadenectomy after CAT scanning. The accuracy, specificity, and sensitivity of the CAT scan in detecting nodal metastasis were 70, 93 and 30 per cent, respectively; this compares favorably with pedal lymphangiography. Seventeen of the patients had radical prostatectomy. The accuracy, specificity, and sensitivity of the CAT scan in depicting local extent of the tumor were 47, 100, and 18 per cent, respectively; although low, no other clinical or biochemical method provides a better result.

Adenocarcinoma↗
PubMed1981

Stage A prostate cancer from pathologist's viewpoint.

Four hundred sixty-five departments of pathology in the United States were asked the following questions pertaining to Stage A prostatic cancer: (1) If a focus of adenocarcinoma is incidentally found in an enucleated specimen, what is the maximum diameter such a lesion may attain and still be considered an A-1 prostatic carcinoma? (2) If adenocarcinoma is incidentally found in a specimen resected transurethrally, how many chips may contain tumor and the lesion still be considered A-1 prostatic carcinoma? (3) What is your "routine pathologic examination" of a prostatic specimen? The majority of pathologists believe that the maximum diameter of a focal (A-1) lesion in an enucleated specimen is 5 mm., and the maximum number of transurethral chips containing tumor in a focal (A-1) lesion is three. The majority of pathologists section every chip when the specimen weighs less than 10 Gm. However, only 12 per cent of the pathologists section every chip when the specimen is greater than 10 Gm., while the others use a random section technique. There is a great diversity of techniques among pathologists in their methods of examining enucleated prostatic specimens.

Humans↗
PubMed1980

Hydrometrocolpos and polydactyly.

Two cases of hydrometrocolpos and polydactyly in female infants with persistent urogenital sinus are reported. The importance of considering hydrometrocolpos as the cause of an abdominal mass in female infants with polydactyly is stressed. Cytologic examination of the vaginal fluid may help in early diagnosis.

Abnormalities, Multiple↗
PubMed1980

The therapeutic role of pelvic lymphadenectomy in prostatic cancer.

We have reported our observations in 72 patients with clinically localized prostatic cancer who underwent radical transpubic prostatectomy and pelvic lymphadenectomy. Of the 72 patients, histologic examination revealed that 54 had tumor confined within the capsule, three had extracapsular spread of the tumor, and 15 had nodal involvement. It is not clear whether the removal of uninvolved lymph nodes had any benefit, but it is certain that it induced no adverse effect on short-term survival. It seems that pelvic lymphadenectomy can increase the survival of those patients with minimal lymph node metastases (one to two nodes). Three patients with more extensive involvement (three to nine nodes) have survived more than three years without evidence of recurrence. The hope for the cure of prostatic cancer, however, probably lies in the development of more effective anticancer agents that destroy whatever cancer cells are not either excised by radical prostatectomy in combination with pelvic lymphadenectomy or neutralized by irradiation.

Aged↗
PubMed1979

Stage A2 prostatic carcinoma: should staging system be reclassified?

Seventy patients with clinically localized prostatic carcinoma were studied for histologic differentiation of primary tumor and the incidence of lymph node metastasis. Also the urologic literature was reviewed regarding the survival of such patients under similar treatment. The results indicate that clinically staged A2 tumors are more aggressive biologically than tumors staged as B1, reaffirming the need for a change in the current staging system. The authors propose reclassification of clinically unsuspected, diffuse carcinoma from the A to the B2 stage.

Adenocarcinoma↗
PubMed1979

Extended pelvic lymphadenectomy for prostatic cancer.

Thirty patients with clinically localized prostatic carcinoma underwent extended pelvic lymph-adenectomy, including the presacral and presciatic (lateral sacral) areas. The first echelon of pelvic nodes to be involved by metastases was the external iliac, obturator, presacral and presciatic. The deep presacral-presciatic nodes were involved almost as often as the more superficial external iliac-obturator group. Metastases limited only to the deep pelvic nodes were found in 14 per cent of the cases.

Adenocarcinoma↗
PubMed1978

Sacrococcygeal teratoma.

Two cases of sacrococcygeal teratomas are presented. One case illustrates the long course of urologic problems produced by a "successful" removal of the tumor. The literature is reviewed, and the characteristics of this congenital tumor are discussed.

Adolescent↗
PubMed1978

Anterior urethral valves.

Three cases of anterior urethral valves, a rare congenital anomaly are reported. Anterior urethral valves probably represent an attempt at duplication of the urethra in the first twelve to fourteen weeks of intrauterine life. The most common type is cusp-like and most frequently located in the bulbar urethra. The presenting complaints are lower tract symptoms, and the diagnosis is usually made by a voiding urethrogram.

Adult↗
PubMed1978

Differences in pathological characteristics and prognosis of clinical A2 prostatic cancer from A1 and B disease.

A retrospective study was done of 53 cases of clinical stages A1 to B2 prostatic carcinomas staged by pelvic lymphadenectomy. The study compared the histologic differentiation, degree of lymphocytic infiltration, incidence of lymph node metastases and type of cellular response of clinical stage A2 to stages A1 and B disease. The available data pertaining to the incidence and survival of patients with stage A2 prostatic carcinoma were analyzed. Our study indicates that 1 of every 3 unsuspected carcinomas is of clinical stage A2. The stage A2 tumors are diffused, with a higher degree of undifferentiation and a higher incidence of lymph node metastases than tumors classified clinically as stages A1 and B1. Also the survival of patients with clinical stage A2 tumors is lower than the survival of patients with clinical stage B1 disease. Clinical stage A2 tumors are more advanced biologically than clinical stage B1 tumors.

Humans↗
PubMed1977

Urographic imaging in neonatal period: radionuclide scan and x-ray.

A retrospective study of efficacy of radioisotopic renal scan intravenous urogram in 10 infants with various urologic diseases showed the scan to be more rapid and accurate in depicting the lesions. Since the radioisotopic renal scan requires less irradiation than the intravenous pyelogram, it should be used first as a screening test in infants suspected of having urologic problems.

Contrast Media↗
PubMed1977

One-stage hypospadias repair.

A surgical technique for correction of hypospadias with chordee in one stage is described. This technique which brings the ectopic meatus up to the tip of the glans was successfully applied in 3 cases of penoscrotal and in 8 cases of penile hypospadias.

Humans↗
PubMed1977

The effects of prostaglandins on sperm motility.

Inflammatory exudates around intrauterine devices were found to produce large concentrations of prostaglandin F2alpha. To evaluate the effect of this substance, 100 semen specimens were incubated in concentrations 100 times greater than that found in normal semen. Motility indices were calculated, and significant inhibition of sperm motility was found. The effect of prostaglandin E on sperm motility is also reviewed. The physiology of prostaglandins and their mechanism of action via the cyclic nucleotide system are discussed.

Humans↗
PubMed1975

Adventitious hysterogram during intravenous pyelography.

This study reports our experience with uterine opacification noted during infusion urography. The phenomenon is observed in 21.7 per cent of urograms performed on adult females. Examples of this entity are presented and the pathophysiology of the uterine opacification discussed.

Adult↗
PubMed1975

Colonic urinary diversion: 10 years of experience.

Experience with 46 colon urinary conduits is summarized. The transverse colon was used in 39 patients and the sigmoid in 7. Initially, we considered widened uretercolic anastomosis with free reflux desirable but later, upon realizing the dangers of reflux, antireflux procedures were incorporated into the operation. Among the advantages of the colon conduit are minimal stomal stenosis, little residuum, less electrolyte disturbance and availability for high and low diversions.

Adolescent↗