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Biomedical subjects

M Golden

Publications and source records attributed to M Golden.

At least 55 records · Page 3Linked to original sources
PubMed1980

Decreased incidence of HLA-A11 and increased incidence of HLA-B8 in a North American population of insulin dependent diabetics.

Seventy-four North American Caucasian insulin dependent diabetics are presented and compared to 100 healthy controls relative to HLA-A and B locus antigens. A highly significant increase in the frequency of HLA-B8 was found (p < 0.01, relative risk 3.67). The presence of HLA-A11 conferred statistically significant protection against disease development in these patients (p < 0.01, relative risk 0.19). There was no significant difference in the frequency of HLA-B7, B8, or B15 between the study and control groups. The patient group does show a significant increase in heterozygosity for HLA-B8 and HLA-B15 when compared to healthy controls (p < 0.05, relative risk 7.17). Increased incidence of HLA-B18 has previously been noted in French and English populations only. Since most of our HLA-B18 patients are of English extraction, it is concluded tht the altered incidence of the HLA-B18 allele in insulin dependent diabetes does persist in this migratory European population.

Diabetes Mellitus↗
PubMed1979

Sequential intellectual recovery after near-drowning.

Sequential neurological and intellectual recovery after childhood near-drowning is discussed. Decisions concerning the persistence and intensity of resuscitation require a knowledge of the natural history of intellectual improvement after rescue from near-drowning. A severe case of fresh-water immersion, leading to recovery, is described. Evidence is presented to suggest that the time interval of one hour before the first spontaneous respiratory gasp forms the upper limit of the apnoeic time bracket after which survival can still be expected, and to indicate that intellectual improvement (to a measured IQ of 97) can occur even after initial decerebrate signs if vigorous therapy is prosecuted. The proportion of cases capable of sequential neurological improvement is unknown. A time base for sequential clinical and intellectual improvement after near-drowning is presented to form a yardstick with which future cases may be compared.

Brain Damage, Chronic↗
PubMed1979

Cancer and sex.

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Counseling↗
PubMed1977

The relationship between dietary intake, weight change, nitrogen balance, and protein turnover in man.

We have examined the relationships between protein turnover, protein synthesis, and protein breakdown and dietary intake, weight change, and nitrogen balance in children who were recovering and had recovered from severe protein-energy-malnutrition. Protein metabolism was measured by giving [15N]glycine and measuring the enrichment of urinary urea. The level of dietary protein did not affect protein metabolism. There were highly significant correlations between both protein flux and protein synthesis and the ad libitum dietary intake, nitrogen balance, and weight change. Over the range of dietary intake, 60 to 270 cal/kg per day, the protein synthesis rate increased 5-fold. Large changes in dietary intake resulted in small changes in protein breakdown, with breakdown being least on an inadequate intake. Changes in the rate of protein breakdown did not contribute to changes in nitrogen balance or body weight.

Body Weight↗
PubMed1977

Leukocyte electrolytes and sodium transport in protein energy malnutrition.

Intracellular electrolytes and sodium transport were measured in leukocytes obtained from malnourished children. In the presence of edema, leukocyte sodium and potassium were raised. The total flux and the glycoside-sensitive portion were increased. Loss of edema was associated with reductions in all these measurements. In marasmus, glycoside-sensitive sodium efflux was reduced compared to recovered values. Sodium was increased and potassium reduced. It is concluded that at least two defects in sodium transport may occur in protein energy malnutrition, an increased passive permeability in kwashiorkor and a reduced active transport for sodium in marasmus.

Biological Transport↗