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Biomedical subjects

M Goldberg

Publications and source records attributed to M Goldberg.

At least 505 records · Page 28Linked to original sources
PubMed1986

Activation of hepatic and inactivation of renal xanthine dehydrogenase activity by dexamethasone during the prenatal period in chick eggs.

In the experiments reported here, the effect of dexamethasone on hepatic and renal xanthine dehydrogenase toward the end of incubation was studied. Dexamethasone injected on day 17 of incubation into the chick eggs increased the hepatic and decreased the renal activity of xanthine dehydrogenase. Furthermore, dexamethasone was found to accelerate fetal development as measured by the precocious decrease of thymidine uptake into nuclear DNA and by the increased fetus weight/egg weight ratio. The data suggest that an activation of xanthine dehydrogenase is caused by a hatching-independent factor and by a factor related to the hatching process.

Animals↗
PubMed1986

Clinical trial of Wistar Institute 17-1A monoclonal antibody in patients with advanced gastrointestinal adenocarcinoma: a preliminary report.

Immunotherapy using monoclonal antibody 17-1A has been performed on 22 patients with metastatic gastrointestinal cancer. Criteria for treatment included objective evidence of advanced colon, gastric, or pancreatic cancer (positive CAT scan or x-rays, elevated tumor markers, and/or abnormal liver function tests). The tumor tissue was antigenically positive in all cases. Performance status ranged from 50 to 100%. No adverse reactions were noted. Of the 22 cases treated, 4 (18%) have died, none have rapidly progressive disease, 4 (18%) have slowly progressive disease, 10 (45%) are considered stable with disease, and none are considered partial or complete responses. It is too early to classify the response in 4 cases. In 6 of 8 patients where anti-idiotypic data was available, death or progressive disease was correlated to negative anti-idiotypic response, and clinical stability to a positive anti-idiotypic response. In the patients considered to be stable, the percent change from pre-treatment serum 19-9 concentrations to current values ranged from -10% to +353%. In the patients who have died or have been classified as slowly progressive the serum 19-9 changes ranged from +13% to +707%.

Adenocarcinoma↗
PubMed1986

[Retrospective evaluation of occupational exposure in epidemiologic studies. Use of the Delphi method].

A method, based on the Delphi technique, for evaluating occupational risks in a quantifiable manner was devised in the course of a case-control study on respiratory cancers in the nickel mining and refining industry in New Caledonia. There were four stages in the evaluation process: identification of eleven potential carcinogenic factors in the company during the 1930-1977 period; grouping of a limited number of work-stations; evaluation of exposure levels for the different factors for each workstation; computation of the cumulative value of exposure for each subject under study. A partial validation study shows that this kind of approach may prove useful for future occupational epidemiological studies.

Carcinogens, Environmental↗
PubMed1986

Endobronchial carbon-dioxide laser therapy.

Twenty-four patients underwent single and multiple carbon-dioxide laser treatments for endobronchial lesions at the Mount Sinai Hospital in Toronto. Fifteen had malignant disease, 2 had benign tumours and 7 had benign strictures. Rigid bronchoscopy with Venturi ventilation was used in all, with the CO2 laser therapy directed down the open end of the bronchoscope. In the majority of cases laser therapy was combined with mechanical débridement, consisting of removal with biopsy forceps and use of the end of the rigid bronchoscope to "core out" the tumour mass. Assessments were made subjectively by the patient and objectively by bronchoscopic examination and post-treatment roentgenography. Worthwhile improvement was noted in patients who had proximal malignant lesions and those with benign lesions at all levels. Overall there was an effective improvement in 18 of the 24 patients.

Adult↗
PubMed1985

Decay B--> psi X.

Explore the source record for details and available documents.

Journal Article↗
PubMed1985

Intra-blood-brain barrier IgG synthesis in cerebral cysticercosis.

Patients with central nervous system cysticercosis show elevated binding of cerebrospinal fluid (CSF) IgG to homogenized cysticercus. To determine whether any of the CSF IgG was the result of de novo intra-blood-brain barrier (BBB) synthesis, CSF and serum samples from six patients were examined for elevated rate of synthesis and oligoclonal bands. Five of the six patients had increased intra-BBB IgG synthesis rate and four of these patients also had oligoclonal IgG bands present in the CSF that were absent in the serum. These results demonstrate intra-BBB IgG synthesis similar to that observed in other infectious and inflammatory diseases of the central nervous system.

Blood-Brain Barrier↗