Biomedical subjects

M Gogora

Publications and source records attributed to M Gogora.

10 recordsLinked to original sources

PubMed1996

Pitfalls in the diagnosis of ectopic hamartomatous thymoma.

We describe four cases of ectopic hamartomatous thymoma with unusual morphological features. In cases 1 and 2 we found a dysplastic glandular component which was often arranged in a cribriform pattern bridging several glandular spaces. In case 2 we found solid adenocarcinomatous areas with infiltrative edges. Case 3 showed widespread smooth muscle differentiation within the spindle epithelial cell component, the presence of multiple clear cell glands which contained a distinct myoepithelial layer and an overall picture which vaguely resembled a sclerosing adenosis of the breast. Case 4 contained frequent foci of multinucleated giant epithelial cells within the markedly cellular spindle cell component: it also showed multiple, hypocellular, myxoid areas containing eosinophilic cords and pearls of squamous cells, and resembled squamous cell carcinoma with a sarcomatoid spindle cell component. We could not find any evidence of a thymic origin or of thymic differentiation in our four cases or in any other reported cases of ectopic hamartomatous thymoma. We believe that ectopic hamartomatous thymomas manifest salivary gland differentiation.

Adult↗

PubMed1993

[Double appendicitis--a rare pathologic entity].

We report on a clinical case of appendicitis duplex with atypical and previously not described localisation of the second appendix at the right colic flexure in a 11 years old patient. Type of localisation and synchronicity of the inflammation have not been reported in literature so far. Pathological classification of the double appendix and problems of synchronous inflammation are discussed.

Acute Disease↗

PubMed1993

[Atrophy of the gastric mucosa and Helicobacter pylori].

The authors investigated the prevalence of Helicobacter pylori (H. p.) in atrophic gastritis in the antrum and/or in the corpus of the stomach (groups I-IV), as compared with mucosae without atrophy. Criteria for elimination were age under 50 years, a case-history of the use of antibiotics during the last 6 months and chronic ingestion of alcoholic beverages. Group IV was formed by probands with pernicious anaemia who were divided into sub-group IVa with atrophy of the corpus and sub-group IVb with atrophy of the corpus and antrum. It was revealed that in probands with pernicious anaemia the presence of H. p. is significantly reduced (p < 0.01) when atrophy was present not only in the corpus but also in the antrum. The authors concluded that atrophic changes in the corpus only do not have a significant effect on the presence of H. p. in the antrum. The presence of H. p. is significantly influenced in a negative sense only when atrophic changes, in particular total atrophy, affect the antral mucosa.

Aged↗

PubMed1992

[Angiodysplasia--a cause of severe hemorrhage in the gastrointestinal tract].

The authors describe a case of relapsing severe haemorrhage from angiodysplasias localized in the small intestine in an eighty-year-old female patient diagnosed only after probatory laparotomy. They discuss the diagnostic possibilities in angiodysplasia of the gastrointestinal tract and how it can be influenced by therapy. Even after resection of the affected portion of the intestine the formation of new angiodysplasias must be foreseen in previously intact areas and those can be the source of further severe haemorrhage.

Aged↗

PubMed1990

[Fibrosing mesenteritis--a surgical problem].

The authors describe three cases of rare fibrotizing mesenteritis in adult patients. In two the aetiological agent was not detected, in the third one it was obviously talcum powder. The disease was manifested as acute abdomen or was detected accidentally. Compression of the visceral vessels caused the development of ischaemic foci with intestinal fistulae. Surgical treatment failed.

Adult↗

PubMed1990

[Morphologic changes in chronic active superficial Campylobacter pylori-positive antrum gastritis after treatment with bismuth].

The authors investigated the effect of one month bismuth treatment (Bismuthi citrici 120 mg per capsule), 4 x 120 mg/day, on morphological changes of the gastric mucosa along with the effect on Campylobacter pylori (CP) in a group of 23 probands with histologically verified active superficial CP positive antrum gastritis. The probands suffered only from functional dyspepsia, to eliminate the action of other disease of the digestive tract on chronic gastritis. Complete eradication of CP occurred in 65.2% and disappearance of granulocytic infiltration as a manifestation of activity in 73.9%. The disappearance of activity correlated with the eradication of CP in 88.2. The authors evaluated also the degree of circular nuclear cellulization (grade 1-3). After one-month treatment it was reduced by 1 grade in 56.5% in the antrum, while in the corpus it remained unaltered in the majority. Complete histological normalization of the mucosa was not recorded.

Adult↗

PubMed1990

[Crohn's disease of the stomach].

The authors describe the incidence of Crohn's disease at an uncommon site the stomach--in a 40-year-old man. With regard to the steadily increasing incidence of the disease, it is important to consider its presence also in uncommon sites in the gastrointestinal tract. The establishment of the diagnosis must be comprehensive, as even histological examination of endobioptic specimens or resected portions need not be unequivocal from the diagnostic aspect.

Adult↗

PubMed1990

[Ischemic colitis as a localized manifestation of ergotism?].

The authors discuss a case of the development of ischaemic colitis in a 69-year-old female patient with superficial thrombophlebitis of the lower extremity treated by a combination of dehydrated ergot alkaloid Secatoxin forte drops with smaller doses of Heparin inj. After ruling out other causes of the development of ischaemia, the authors consider ischaemic colitis a local manifestation of ergotism.

Aged↗

PubMed1989

[Incidence of chronic gastritis in young patients with functional dyspepsia].

The authors made during a 16-month period in 226 patients the diagnosis of functional gastric dyspepsia (144 women and 82 men aged 20 to 50 years). The differentiating criterion was a pathological organic finding in the upper part of the digestive tract, a pathological finding on the liver, gallbladder and pancreas as well as a pathological laboratory finding. The probands were divided by age into two groups and compared with a control group with similar differentiating criteria; however, the latter had no dyspeptic complaints. The differences in the incidence of chronic gastritis were not significant. From the investigation the following conclusions ensue: 1. Chronic gastritis is not the prerequisite factor of dyspepsia. 2. With advancing age the incidence of chronic gastritis increases. In group of men with functional dyspepsia and without it at the age of 35 years a normal antral mucosa is found only in 1/4 and a normal mucosa of the corpus in 1/2, whereby the corresponding figures at the age of 50 are 1/10 and 1/3. In the group of women with functional dyspepsia and without it at the age of 35 years a normal mucosa of the antrum is found in 1/3 and in the corpus in 2/3, the corresponding figures at the age of 50 years are 1/5 and 1/2. Under the age of 50 the authors recorded a higher incidence of chronic gastritis in the male population (antrum 96.1%, corpus 66.7%), as compared with women (antrum 76.9%, corpus 54.8%).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMedDate not supplied

[Chronic active surface-positive Campylobacter antrum gastritis-- morphological changes 1 year after treatment with bismuth].

The works is based on a previous investigation published in the journal Vnitrní Lékarství, 36, 1990, 8, pp. 759-762. The authors investigated morphological changes of the gastric mucosa and the presence of Campylobacter pylori (CP) in probands with chronic active surface CP positive antrum gastritis one year after treatment with a bismuth preparation (Bismuth citrate 120 mg per capsule made on prescription) for a one-month period 4 capsules per day. This concerned probands with functional dyspepsia without a history of alcohol intake. After a one-year interval eradication of CP persisted in 8 probands (53.3%); in 7 patients (46.7%) there was a relapse of CP positivity. The authors confirmed that CP and active chronic gastritis are associated. Chronic non-specific inflammatory cellulitis persisted after one year with the same intensity in 17 probands (74%), in 6 it increased by one grade (26%). Improvement or complete recovery of the histological finding was not recorded in any of the patients. In the corpus of the stomach the unaltered finding persisted. Morphological changes were always directly proportional to the presence of CP. Its eradication appears to be causal treatment of chronic active surface CP positive antrum gastritis, one of the groups in the wide spectrum of chronic gastritis.

Adult↗