Search PubMed⌕ Search

Biomedical subjects

M Glezerman

Publications and source records attributed to M Glezerman.

At least 127 records · Page 7Linked to original sources
PubMed1986

Bilateral ovarian involvement as the only manifestation of malignant lymphoma.

A 16-year-old girl presented with a large pelvic mass. At laparotomy, bilateral ovarian tumors were disclosed and bilateral salpingo-oophorectomy was performed. No evidence of extra-ovarian disease was found. Histopathological examination and histochemical immunoperoxidase studies demonstrated the tumors to be malignant lymphoma of the lymphoblastic type. The patient had radiotherapy and systemic chemotherapy and more than 10 years later she is alive with no evidence of recurrent disease. The rarity of ovarian involvement as the initial manifestation of malignant lymphoma is discussed. The question of whether this patient represents a case of a primary ovarian malignant lymphoma or merely represents a case of ovarian initial manifestation of an occult generalized disease cannot be answered.

Adolescent↗
PubMed1986

The setting-up of an ambulatory urologic-gynecologic service. Management of patients and results.

An ambulatory set-up is presented which comprises a simple armamentarium for management of women complaining of urinary stress incontinence. Since history appeared to be not sufficiently reliable for management of patients, diagnosis was based mainly on cystomanometry and radiology. Of 58 women who have completed at least six months of follow-up, 11 had been diagnosed as suffering from detrusor instability (DI) and 47 from genuine stress incontinence (SI). Treatment was medical in the former group and surgical in the latter. Significant or complete relief of symptoms was reported in 91% of the former group and in 81% in the latter.

Adult↗
PubMed1986

Evaluation of reliability of history in women complaining of urinary stress incontinence.

It was the aim of this study to evaluate critically the value of history in patients complaining of urinary stress incontinence. Diagnosis was established mainly by radiologic and cystomanometric assessment. History included 21 symptoms subdivided into various items. Only 3 symptoms were proven significant in distinguishing between various diagnostic groups. Assessment of stress incontinence should be regarded as incomplete without other means of evaluation in addition to history.

Adult↗
PubMed1986

Choriocarcinoma associated with undetectable levels of human chorionic gonadotropin.

A case of choriocarcinoma is presented which developed during close follow-up for hydatidiform mole. Serum levels of beta subunits of human chorionic gonadotropin (beta-HCG) were assessed by radioimmunoassay (RIA) before, during, and after diagnosis of choriocarcinoma and remained below the sensitivity level of the assay. To our knowledge, this is the fourth reported case where choriocarcinoma was not associated with the presence of elevated beta-HCG levels.

Adult↗
PubMed1985

Steroid receptors in a granulosa cell tumor (GCT) in an infant with precocious puberty.

A granulosa theca cell tumor was found in a 10-month-old girl with precocious puberty. Steroid hormone receptors were measured in fractionated tumor cells. Estrogen and progesterone receptors were measured in the cytosol, and estrogen receptors were measured in the nuclear fraction of the tumor. Although high affinity (Kd 0.4 nM) progesterone receptors were present in the cytosol of this tumor-54 fmole/mg protein-no cytosolic estradiol receptors could be detected; however, these receptors were found to be tightly bound to the nuclear fraction of the tumor. The nuclear protein had lower apparent Kd for the hormones-5.4 nM. This tumor produced and released various steroid hormones. The plasma steroid levels before removal of the tumor were 1,200 pg/ml for estradiol, 350 pg/ml for testosterone, and 5 ng/ml for progesterone. All these steroid hormones declined postoperatively to undetectable levels, with total remission of pubertal signs. Plasma-dehydroepiandrosterone, prolactin, and gonadotropin levels were in the normal range before and after surgery. These results suggest that cytosolic progesterone receptor as an estrogenic marker and/or nuclear estrogen receptors may predict the hormonal dependency of these estrogen-producing tumors.

Cell Nucleus↗
PubMed1984

The Allen Masters syndrome revisited. Successful treatment by laparoscopy.

The main underlying pathology of the Allen Masters syndrome is based on lacerations of the broad ligament. This sometimes incapacitating disease is expressed by persistent pelvic pain, dyspareunia and menstrual disturbances. Treatment modes employed hitherto consisted of either suturing the peritoneal defect or of hysterectomy. We have treated four patients by simple fulguration of the peritoneal laceration, performed during laparoscopy. Results were excellent. It is suggested that this treatment mode may replace more extensive surgery.

Adnexa Uteri↗
PubMed1984

The cervical factor of infertility and intrauterine insemination.

Results with intrauterine insemination in 25 couples are presented. The indication for this procedure was a cervical factor of infertility. After an extensive fertility survey in both partners, intrauterine insemination was performed four to seven times per cycle with up to 0.8 ml fresh semen per insemination. Only the first ejaculatory spurt was used. Prophylactic antibiotics were given to all female partners during the insemination period. Within a mean of 6 months 13 couples reported pregnancies (52%). Except for one midtrimester abortion that was probably due to obstetrical reasons, the abortion rate was 33.3%. There were no side effects related to the insemination procedure. Our data indicate that, with appropriate safeguards, intrauterine insemination should be regarded as a safe and effective method for the treatment of the cervical factor of infertility.

Adult↗
PubMed1984

Artificial hydramnion. A simple method of verifying premature rupture of the membranes.

Accurate diagnosis of premature rupture of the membranes is of paramount importance for proper treatment. Currently available methods of diagnosing this complication of pregnancy are not satisfactory. A new, simple, noninvasive method occludes the amniotic outflow with a cervical cap on the external cervical os, permitting the formation of an artificial hydramnion. Observation of this hydramnion formation using ultrasonography and the release of accumulated amniotic fluid after removal of the cap are strong evidence of the existence of premature rupture of the membranes. We used this method in 17 cases.

Adult↗
PubMed1982

The effect of estrogen and gestagen on the mucus production of human endocervical cells: a histochemical study.

The effect of hormonal stimulation on the intracellular mucus production of the endocervical cells was histochemically and morphometrically investigated. Twenty-seven cervixes from patients who had received estrogen or gestagen prior to hysterectomy were examined. "Upper" versus "lower" cervix and "small" versus "large" crypts were compared in both groups of patients. The histochemical analysis of mucins within the cells was based mainly on the combined alcian blue/periodic acid Schiff (AB/PAS) techniques at various pH levels. A semiquantitative estimation using cell counts and statistical evaluations was done for each staining method. The results indicate that sex hormones influence the chemical composition of endocervical mucus production. In addition, the nature of the intracellular mucus varies with the cryptal size and location within the cervical canal.

Alcian Blue↗
PubMed1982

Polyzoospermia: a definite pathologic entity.

Polyzoospermia has been repeatedly associated with reduced fertility and increased rates of spontaneous abortion. We examined semen samples of 1374 infertile men and found an incidence of 4.2% of semen with a sperm density exceeding 250 X 10(6) sperm cells/ml. The spontaneous pregnancy rate in 30 evaluated couples in whom the male partner presented with polyzoospermia was 38.7% and the spontaneous abortion rate was 25%. Sperm penetration tests revealed normal mucus-penetrating ability in 29 of 30 men examined. The reason for reduced reproductive performance in polyzoospermic men does not seem to be disturbed sperm mucus interaction.

Abortion, Spontaneous↗
PubMed1981

[Gonadotrophin therapy (author's transl)].

Strict selection of patients is of paramount importance with a view to obtaining optimum results in the treatment of infertile men with gonadotrophins (HMG/HCG). The use of algorithmic tables permits the exclusion of cases of primary orchiopathy, or of genetic or other causes of infertility independent of the endocrine system. Within the scope of a retrospective study this paper gives an account of the results obtained with gonadotrophin therapy in 25 men presenting severe oligozoospermia. The patients had been selected according to the above-mentioned algorithmic schedule, and their serum levels of FSH, LH and testosterone were determined before and after GNRH stimulation. The present study establishes criteria for the selection of such patients as can be treated successfully with gonadotrophin.

Chorionic Gonadotropin↗
PubMed1981

Two hundred and seventy cases of artificial donor insemination: management and results.

Whenever male infertility is resistant to therapy, artificial donor insemination (AID) may be employed as a very efficient tool to provide the infertile couple with the desired child. Two hundred and seventy cases of AID were reviewed for the following information: indication for AID, age of the female partner, length and type of infertility, socioeconomic state, ovulatory pattern prior to and following initiation of the AID program, acceptance of the procedure by the male partner, and outcome of pregnancies. The over-all pregnancy rate was 85.2%. There were 159 live births, 2 perinatal deaths, 38 spontaneous abortions, 1 ectopic pregnancy, and 1 therapeutic abortion due to rubella infection. Forty patients discontinued treatment with or without notification. Treatment success was significantly affected by age of the woman, duration of infertility, socioeconomic state of the couple, and the husband's acceptance of the AID procedure. Of all pregnancies, 86.5% occurred within six treatment cycles. Repeated pregnancies required similar numbers of treatment courses per pregnancy.

Abortion, Incomplete↗