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Biomedical subjects

M Gilli

Publications and source records attributed to M Gilli.

32 records · Page 2Linked to original sources
PubMed1976

[The influence of noise on the human central nervous system (author's transl)].

We studied the effects of the road noise on the central nervous system in a group of 40 normal adult subjects. The neurophysiological research included the following parameters: acoustic and visual evoked cortical potentials, percentage of EEG desynchronization, contingent negative variation (CNV) and sleep-EEG. The results showed in every subject a reduction of the amplitude of the acoustic evoked potential recorded during the road noise as against to that one we recorded during normal silence. This fact, also in contrast to the stability of the visual evoked potential during the road noise and the normal silence, permitted to verify the existence of a neuronal occlusion phenomenon interesting the evocative acoustic stimulus when the noise is provided at the same time. The study of the EEG desynchronization during the road noise compared to that one during the normal silence did not give any statistically difference. The study of the CNV gave analogous results. Only if we complete the research with the study of the base-personality of every subject by the Rorschachtest, we found significant differences among the neurphysiological parameters as the EEG desynchronization and the CNV during the normal silence and the noise in relation to the different levels of anxiety and endotensivity of every subject.

Acoustic Stimulation↗
PubMedDate not supplied

Natural killer cells in Bal and peripheral blood of patients with idiopathic pulmonary fibrosis (IPF).

Idiopathic Pulmonary Fibrosis/ Usual Interstitial Pneumonia (IPF/UIP) represents the most important interstitial pneumonia. ATh2 cytokine pathway predominance, favoring collagen deposition, associated to a deficit in (IFN- gamma) network, seems to be involved in the pathogenesis of this disease. Nonetheless, few data are available about the potentially involved cells. Natural killer cells (NK), are one of the most important subsets implicated in the IFN-gamma network. The aim of this study was to assess NK cells, both in BAL and peripheral blood of 11 patients suffering from IPF (group A) with respect to 11 patients with other interstitial pneumonia (Group B). Our results did not show any statistically significant difference in NK percentage in BAL between group A and B. On the contrary, patients with IPF showed a higher percentage of NK cells (t = 2.41; p < 0.05) and absolute number of cells (t = 2.32; p < 0.05) in peripheral blood, as well as a strong positive correlation between circulating and BAL NK cells (r = 0.69; p < 0.05). This finding shows, for the first time, a relationship between peripheral and lung resident cell environments in humans suggesting a possible systemic involvement in the natural history of IPF.

Antibodies, Monoclonal↗
PubMedDate not supplied

Risk factors for tuberculosis infection and disease.

We conducted a prospective study among patients with newly diagnosed pulmonary tuberculosis and their close contacts to identify clinical and socio-economic risk factors for tuberculosis infection and disease. Ninety patients and 277 contacts were enrolled. The prevalence of infection was 45% [95% confidence interval (CI): 39-51%] among contacts. Factors like age, gender, race, delay of diagnosis and treatment, presence of cavitation in chest radiograph, cough, unwillingness to cover the mouth, volume of air shared by close contacts and patients were investigated. Inclusion of all these factors in a multivariate logistic regression model showed that only delay in diagnosis is significantly associated to the increase of prevalence (p < 0.0002), documenting that delay in diagnosis of the case is a crucial factor for tuberculosis infection and/or disease.

Adult↗
PubMedDate not supplied

[Neurotoxic action of muzolimine at high doses in uremic patients. Observation of a group of 29 subjects].

We report the results of a study on 29 patients affected by renal chronic insufficiency and treated with high doses of muzolimine. From our data it results that to the muzolimine is probable due a neurological syndrome very similar to combined sclerosis. Up today, it is not possible to know how and where the muzolimine develops its neurotoxic effect.

Combined Modality Therapy↗
PubMedDate not supplied

Isolated hypophyseal tuberculoma: case report.

A 45-year-old woman, lifelong resident in Turin presented an isolated tuberculous granuloma of the hypophysis with no other systemic localizations. Diagnosis could be established only by biopsy. With antituberculous therapy the intracellular tumor regressed but not the endocrine disorders.

Female↗