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Biomedical subjects

M Gignoux

Publications and source records attributed to M Gignoux.

At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

Adjuvant therapy for resectable oesophageal cancer: results of a pilot study.

119 operable patients with an epidermoid oesophageal carcinoma were treated preoperatively with a combination of chemotherapy (cisplatin 80 to 100 mg/m2: 2 cycles) and radiotherapy (two courses of 18.5 Gy). The response rate was evaluated on resected specimens. The toxicity was moderate. The pathological study of the 101 resected specimens showed no residual tumor (CR) in 24 patients and partial response (PR) in 46. The response rate (CR + PR) was better in stage I (89%) than in stages II and III. A controlled study is needed to evaluate the effectiveness of this protocol as regards survival.

Cisplatin↗
PubMedDate not supplied

[Complications of diverticular disease of the colon. Apropos of 247 cases].

In the last five years, 7 teams, members of a surgical club of lower Normandy, have performed 1,136 colon procedures, including 247 for severe diverticular disease. The patients were grouped in two categories according to the severity of the complications presented: 159 sub-acute complications including 137 acute cases of sigmoiditis (diverticulitis, peri-colic micro abscesses, pseudo-tumoral forms) and 22 fistulae, 88 severe acute complications including 60 generalized peritonites, 12 huge abscesses, 9 occlusions and 7 hemorrhages. The total post-operative mortality is 6 p. cent. It is quite different in the surgery of sub-acute complications (0.6%) and the surgery of acute severe complications (16%). The total morbidity reaches 14.8 p. cent. Complications are more frequent and more severe in acute forms (18.5%) than in subacute forms (10.5%). At long term, 10.8 p. cent of the patients operated upon, kept a permanent colostomy (25 p. cent in acute forms vs 2.3 p. cent in subacute forms). 89.2 p. cent have a normal digestive tract following treatment (97.7 p. cent in subacute forms and 53 p. cent in acute forms).

Abscess↗