[Contribution to the study of vitamin-resistant rickets. Characterization of a new clinical form: osteodystrophy with dwarfism, hypercalciuria and gluco-aminic diabetes].
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Biomedical subjects
Publications and source records attributed to M Georgescu.
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The authors make an analysis of the modalities for the integration of the bacteriological examinations for M. tuberculosis in 3 sanitary units in the city of Jassy. In view of detecting pulmonary tuberculosis, although an improvement was noted in the activity of integration, an intensification is necessary of the culture examination in the present stage of the tuberculous endemia. Also a more close cooperation is necessary between laboratories from sanitary units, and with the central laboratory for cultures of M. tuberculosis. With regard to extra-respiratory tuberculosis the large number of demands for bacteriological examinations from the hospital as well as from the ambulatory units, makes necessary the organization of diagnostic centres by specialities.
Some aspects were analyzed, of drug resistance of primary and secondary type in mycobacteria strains from patients with pulmonary tuberculosis in a district area, between 1975 and 1979. The results were compared with those obtained in a similar study performed in 1971--1974. While the primary resistance has persisted at an approximately similar level under the aspects of frequency and incidence in the two periods (11% and 13,6%, and 4,0-- and 4,5% respectively), the secondary resistance has marked a significant decrease (36% and 12,3 per 100 000 inhabitants in 1979). The intensive use in the recent years of rifampicin and etambutol in the therapy of tuberculosis explains the new aspects noted in the structure of the primary and of the secondary drug resistance. Thus, an increase was noted in resistance to rifampicin, which, between 1977 and 1979 was above the values recorded for primary resistance to streptomycin.
The authors make an analysis of bacteriological data concerning patients with tuberculosis from a certain area (the Jassy County) which have been recorded between 1971 and 1980. An analysis is presented of the instantaneous and of the maximal prevalence of tuberculous bacilli carriers in the urban and the rural environments, and the incidence of tuberculosis in children and adults, also in the urban and the rural media. Some other aspects are studied of primary drug resistance, as well as of secondary resistance. The data presented in the paper stress the major role of the bacteriological investigation in the epidemiological follow-up of tuberculosis, as well as the fact that bacteriological indicators are capable to evidence essential aspects of the evolution of tuberculosis endemia in a certain area.
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In a group of 51 women who had given birth to giant children, the glucose tolerance test (GTT) was performed at entry in the study and after intervals of 6 to 12 years. The results of the first determination, estimated according to the WHO's criteria (1980), have revealed an impaired glucose tolerance (IGT) in 7 cases (14%); the second determination showed IGT in 10 cases (20%) and diabetes mellitus in 2 (4%). Insulinemia assays, concomitant with the second performance of GTT, showed the highest values in the diabetic subjects, moderate values in those with IGT, and low values in those with normal glucose tolerance. The presence of obesity in some cases could not be considered as fully responsible for the glucose tolerance impairment in the women with fetal gigantism. The dynamics of glucose tolerance disorders showed variations in time, i.e. the initial pathologic changes were no more recorded on the second testing in the same subjects, while women with normal initial GTT showed high insulinemia or IGT on the second determination.
The authors present 15 cases of patients with pharyngo-oesophageal foreign bodies, of which 6 occurred in subjects with a normal, healthy oesophagus. In two cases the foreign bodies were eliminated spontaneously, one was extracted by endoscopy, two through cervicotomy and one through thoracotomy. The author stress the fact that dental prostheses are very rarely swallowed, and the deglutition of a live fish is mentioned --. In 7 patients the foreign body became struck in an old post-caustic oesophageal stenosis. In one of these patients the foreign body was extracted by thoracotomy, in 3 cases gastrostomy was performed, in 2 cases colo-oesophagoplasty was necessary and in one case the oeso-colic stenosis was recalibrated. The late results were excellent, excepting one case when the patient died a short time after surgery through a cerebral vascular accident. The therapeutic attitude was differentiated in relation with the condition of the oesophagus, the site of the foreign body and the time of hospitalization.
The present paper reports on a case of spontaneous rupture of the urinary bladder in an alcoholic who ingested a large amount of alcoholic drinks. The presented a misleading uroperitoneum, without signs of peritoneal irritation and was operated under emergency conditions. There were no urinary disturbances during the first 48 hours after admission. The diagnosis was established prior to surgery owing to association of the abdominal phenomena (pain, abdominal meteorism with intestinal paresis) with urinary signs (haematuria), against a background of alcoholic intoxication, confirmed by cystography, the only method that can reveal with certainty spontaneous rupture of the urinary bladder.