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Biomedical subjects

M Georgescu

Publications and source records attributed to M Georgescu.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[The E.E.G. and E.M.G. findings in sudanophilic leucodystrophy (author's transl)].

Four patients with infantile familial sudanophilic leucodystrophy confirmed histologically and biochemically were investigated by E.E.G. and E.M.G. The E.E.G. showed a severe, non-specific slow wave abnormality, of moderate voltage and disorganized in 2 cases, with some critical' tonic' discharge. E.M.G. study was normal in relaxed muscle; peripheral nerve stimulation, however, revealed marked slowing of motor conduction velocities favouring a segmental demyelinisation process, which was ultimately confirmed histologically. This study underlines the value of investigation of infantile encephalopathies.

Cerebral Cortex↗
PubMedDate not supplied

Safety and efficacy of insulin lispro in patients with diabetes mellitus.

Lispro is a human insulin analogue with a very rapid onset of action, and a shorter duration of activity than soluble insulin. In order to assess the therapeutical value of lispro, we have had an open-label, non-comparative study, for 12 weeks, involving 19 IDDM patients. The treatment regimen with lispro and Humulin N has been adapted depending on each patient characteristics. Patients attended three visits, and the main metabolic control parameters included values of hemoglobin Alc, fasting and postprandial blood glucose monitoring. The patients themselves monitored their blood glucose using a glucometer. The mean age value of 19 patients (8 females and 11 males) was 22.32 (+/- 13.59) years. In patients previously receiving insulin treatment, therapy with lispro insulin significantly reduced postprandial glucose values. Lispro has been administered t.i.d. in 14 patients, and b.i.d. in 5 patients. At visit 1, mean value of HbAlc was 10.32% (+/- 1.63%); at visit 3, mean HbAlc was 9.90% (+/- 1.59%). Total insulin daily dose and the rate of short and long acting insulin did not change from visit 1 to visit 3. There has been reported only one serious adverse event during the study: a ketoacidosis due to a technical dosing error. Ten patients have reported mild hypoglycemic episodes. The outcomes of clinical study and of Quality of Life Questionnaire suggests that lispro--the first human insulin analogue used in humans--is effective, safe, and it is broadening beneficially the spectrum of insulins.

Adolescent↗
PubMedDate not supplied

[The results of the Ravitch-Sutherland technic for surgical correction in pectus excavatum].

The aim of our study was to assess the functional and cosmetic results after performing a modified Ravitch-Sutherland procedure in children presenting with excavatum. A series of 31 children with ages ranging between 5 and 16 years, presenting with pectus excavatum, were operated between 1986-1996 in our service. In 5 cases surgical treatment was required by the presence of respiratory and/or cardiac functional impairment due to the malformation. In the other 23 cases operation was performed mainly for cosmetic reasons. In all cases a modified Ravitch-Sutherland procedure was performed. Modification consisted in renouncing at the plicature of the perichondra and in associating a diaphragmatic elongation and Bedouelle laparoplasty in all cases. Longitudinal sternotomy was performed in 2 cases with severely impaired ventilatory capacity. Functional and cosmetic results were good in all cases. In 2 cases, in which recurrence of the condition was observed, a second identical procedure was performed, with a good result. The interval between the operation and the moment of long-term evaluation ranged between 3 months and 11 years. We conclude that the modified Ravitch-Sutherland procedure represents an effective method for the treatment of pectus excavatum cases, offering good functional and cosmetic long-term results.

Child↗
PubMedDate not supplied

[Structural aspects at the individual level in the epidemiological process in human toxoplasmosis].

Intradermoreaction with toxoplasmin in apparently healthy subjects gave positive reactions in 13% of the cases. The mothers of children with neuropsychical diseases and congenital malformations were positive to toxoplasmin in 62-63% of the cases and with the Sabin-Feldman reaction in 9.6-13.8%. High proportions of positive results. (29.1-30%) were obtained with both tests in the children with neuropsychical diseases and congenital malformations. Host-parasite relationships in the early period of embryonic development deeply affects the normal evolution of the embryo and foetus. The individual structural level of the epidemiologic human toxoplasmosis process is conditioned by the moment at which the host-parasite relationships are established.

Adolescent↗
PubMedDate not supplied

Not only quantitative but also qualitative changes of serum immunoglobulins in diabetes mellitus.

To extend previous observations on the quantitative changes of IgA and other serum Ig in diabetics, additional immunochemical investigations were carried out in 96 patients, 63 males and 33 females, mean age 43.5 +/- 15.7 years, 51 with type 1 (insulin-dependent) and 45 with type 2 (non-insulin-dependent) diabetes. The immunological data were correlated with the clinical-metabolic aspects. In the whole group, the IgA level was increased (144.1 +/- 57.2 I.U.). Significant differences were recorded with respect to age for IgG, to age and diabetes type for IgA, to sex for IgM. Qualitative Ig changes, reflecting disturbances of molecular structure, mainly for IgG, seldom for IgM, but never for IgA, were observed in 20% of the patients with both types of diabetes, more seldom in cases with long disease duration. The IgG with qualitative changes were purified and their functional capacity of inhibiting the natural cytotoxic activity (NK) was tested in comparison with that induced by pretreatment of the effectory cells with normal IgG. Some of these modified IgG showed a reduced capacity of inhibiting the NK activity. These data confirm the existence of certain quantitative changes of the main serum Ig in diabetics and reveal the presence of qualitative disorders of the IgG molecules, with consequences on their functionality.

Adult↗
PubMedDate not supplied

[Mycobacterial drug resistance in patients with pulmonary tuberculosis].

The drug resistance of 1,860 human mycobacterial strains was analysed. Of these 987 were isolated from new cases and 873 from cases who underwent a treatment for pulmonary tuberculosis. The investigation lowered 3 years (1986-1988). It resulted that the frequency of primary resistance was of 23.8% and that of secondary resistance was of 47.6%. As part of primary and secondary resistance, mono-resistance to SN and bi-resistance to SN and INH were the most common.

Antitubercular Agents↗
PubMedDate not supplied

Cholesterol and lipid levels in the hair: indicators of the lipid metabolism balance.

A new method of long term, retrospective evaluation of the lipid metabolism balance, by cholesterol and lipid assays in the human hair, is described. The correlation index between the blood and the hair cholesterol and lipid concentrations was + 0.980 and + 0.9925, respectively. The effects of hypolipemic diet and drug therapy on the cholesterol and lipid values were studied comparatively in the blood and in successive hair segments. The results demonstrate that the new method permits an evaluation of the therapy effectiveness and of the lipid metabolism variations during several weeks or months.

Cholesterol↗
PubMedDate not supplied

[The effectiveness of some culture media with pyruvic acid bases for the isolation of mycobacteria from sputum].

The authors have studied the value of culture media based on pyruvic acid (the Dixon medium and an original medium called P.T.) in the isolation of mycobacteria from sputum, as compared with the Löwenstein-Jensen medium. The studies were carried out in two groups of patients: 1043 samples were collected from ambulatory patients and 1740 samples were collected from hospitalized patients. The superiority of the Dixon and of the P.T. media was confirmed by the increased percentage of positive cultures (11% and 20% respectively) as compared with the Löwenstein-Jensen medium. With these media it was possible to isolate mycobacteria 7--14 days earlier than with the other media. On the basis of the results obtained the authors recommend the use, in parallel, especially in those cases when the samples contain only a small number of bacteria, of the Löwenstein-Jensen medium and one of the media based on pyruvic acid.

Culture Media↗