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Biomedical subjects

M Geniaux

Publications and source records attributed to M Geniaux.

At least 37 records · Page 2Linked to original sources
PubMed1988

Evaluation of muscular lesions in connective tissue diseases: thallium 201 muscular scans.

We performed thallium 201 muscle scans to assess muscular involvement in 40 patients with different connective tissue diseases (7 with dermatomyositis, 7 with systemic lupus erythematosus, 12 with progressive systemic scleroderma, 2 with calcinosis, Raynaud's phenomenon, esophageal involvement, sclerodactyly, and telangiectasia (CREST) syndrome, 3 with monomelic scleroderma, 6 with morphea, and 3 with Raynaud's disease). Only 12 of these patients complained of fatigability and/or myalgia. Electromyography was performed and serum levels of muscle enzymes were measured in all patients. Comparison of thallium 201 exercise recording with the other tests revealed that scan sensitivity is greater than electromyographic and serum muscle enzymes levels. Thallium 201 scans showed abnormal findings in 32 patients and revealed subclinical lesions in 18 patients, while electromyography findings were abnormal in 25 of these 32 patients. Serum enzyme levels were raised in only 8 patients. Thallium 201 scanning proved to be a useful guide for modifying therapy when laboratory data were conflicting. It was useful to evaluate treatment efficacy. Because our data indicate a 100% positive predictive value, we believe that thallium 201 scanning should be advised for severe systemic connective tissue diseases with discordant test results.

Connective Tissue Diseases↗
PubMed1987

Linear cutaneous neuromas (dermatoneurie en stries): a limited phakomatosis with striated pigmentation corresponding to cutaneous hyperneury (featuring multiple endocrine neoplasia syndrome?).

A 60-year-old woman developed a progressive linear pigmentation on the trunk. Skin biopsy demonstrated an increase in the number and size of neural fibers in the dermis. Clinical and paraclinical investigations of this unusual disease showed findings similar to the hereditary type of Sipple syndrome (multiple endocrine neoplasia syndrome, Type 2b). Such findings as Marfanoid habitus, abnormal electromyography and hypertrophy of the corneal nerves suggest that our patient's disease and Sipple syndrome are identical. However, such other symptoms of Sipple syndrome as presence of endocrine tumors are absent. Questions of long-term prognosis and physiopathogenicity are raised, since no nerve growth factor was detected in this patient. The name of linear cutaneous neuromas is suggested for the patient's lesions, and a possible association with the pigmentation and cutaneous neuromas of the MEN 2b syndrome.

Biopsy↗
PubMed1987

[Acne and osteoarticular manifestations].

Certain severe forms of acne vulgaris may be accompanied by disorders of the locomotor system. Fulminant acne is manifest as an acute disorder with an alteration of general health and with fever, the onset of painful, necrotic skin lesions, myalgia and arthralgia with arthritis of one or more joints. Acne conglobata, a chronic disorder, is defined by the presence of comedones in sebaceous gland ducts and its progression to form nodules and pustules, leaving indelible scars. Osteoarticular involvement which occurs during the course of acne conglobata, and whose incidence is difficult to determine, is characterized by the frequent presence of sacroiliac inflammation. However, these two forms of acne are often confused and the authors outline differences between them. A more accurate identification of cutaneous manifestations would perhaps provide an eventual classification of "rheumatic disturbances of acne" whose nosological category has not yet been determined.

Acne Vulgaris↗
PubMed1985

[Cerebral lesions in a case of Degos' disease].

The central nervous system may be involved in Degos disease, but neuropathologic observations are still few. We report a typical case with cerebral involvement. The diagnosis was suggested by the characteristic skin lesions and vascular damage. In the central nervous system, occlusive changes of small arteries were responsible for areas of ischaemic necrosis. These foci of infarction were of varying size, age and distribution. Intestinal lesions were discrete and death was due to several cerebral infarcts.

Adult↗
PubMed1984

Bowenoid papulosis. Demonstration of human papillomavirus (HPV) with anti-HPV immune serum.

Two cases of bowenoid papulosis (BP) occurred. The presence of human papillomavirus was demonstrated in one patient. In the other patient, condyloma acuminatum developed after initial spontaneous improvement in his lesions. The discovery of a possible oncogenic virus in BP and the epidemiologic behavior of carcinoma in situ and multicentric carcinomas suggest the need for a very careful follow-up evaluation of such lesions. Bowenoid papulosis may be a chronic dysplasia with a variable long-term prognosis linked to a cocarcinogenic factor.

Adult↗
PubMed1975

[Lepromatous leprosy after BCG vaccination].

The authors describe an eruption of cutaneons nodules after a BCG vaccination. Investigation demonstrated that the lesions were caused by Lepromata. An increased number of B lymphocytes was observed in the bloodstream. Ryphampycin was used with good results.

Adolescent↗