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Biomedical subjects

M Gembicki

Publications and source records attributed to M Gembicki.

107 records · Page 6Linked to original sources
PubMedDate not supplied

Total and free thyroxine in patients with liver cirrhosis.

In 11 patients with compensated and 10 with decompensated liver cirrhosis the following determinations were carried out: total thyroxine serum concentration (T4), triiodothyronine-binding coefficient (T3BC), free thyroxine by the dialysis method (DFT4), free thyroxine index (FT4I) and absolute value of free thyroxine (ADFT4). A statistically significant rise of T3BC, DFT4, ADFT4 and FT4I was observed only in the group of decompensated cirrhosis. It is supposed that these changes develop not as a result of excessive production of thyroid hormones but due to disturbances in the binding capacity of the proteins which bind thyroid hormones and also due to an impaired degradation of these hormones in the liver.

Diagnosis, Differential↗
PubMedDate not supplied

[The assessment of regional cerebral blood flow using HMPAO-SPECT during depressive episode and in remission].

Twenty patients who met the DSM-IV criteria for major depressive disorder were investigated at rest using Single Photon Emission Computed Tomography (SPECT). Participation in the study required a minimum score of 18 points on the 17-item Hamilton Rating Scale. All patients were drug free for at least one week before the SPECT scan. Assessments were made twice during depression and after recovery. Regional tracer uptake was measured by a semiquantitative method. The reference region was delineated on the cerebellum. In remission a significant increase of 99m Tc-uptake in almost all regions of interest was observed what may point on the improvement of regional blood flow after recovery from depression. For most regions except right frontal and left parietooccipital there were no significant differences of tracer uptake between patients with bipolar and unipolar depression. The negative correlation between regional cerebral blood flow and Hamilton score was found in temporal areas and left temporo-parietal region. We did not find the influence of age on regional cerebral blood flow. In conclusion, during depression global reduction of brain metabolism was observed, which may point on the role of subcortical nuclei with diffuse cortical projection in pathogenesis of depression.

Adult↗
PubMedDate not supplied

[The Landau-Kleffner syndrome. SPECT and EEG investigations].

Four children (three boys and one girl) with acquired epileptic aphasia (the Landau-Kleffner syndrome) have been observed in the Department of Developmental Neurology University of Medical Sciences in Poznań. We present the dynamic of clinical symptoms and fluctuations in EEG studies. The changes in the brain in single photon emission computed tomography (SPECT) during remission of clinical symptoms are discussed.

Brain↗