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Biomedical subjects

M Geary

Publications and source records attributed to M Geary.

67 records · Page 4Linked to original sources

Shoulder dystocia--is it predictable?

An unmatched comparative study is described to determine if routine clinical indicators are useful predictors for shoulder dystocia. Parity, maternal weight gain during pregnancy, and a history of a previous large baby and increased operative vaginal delivery rate were more often associated with shoulder dystocia. No other significant associations were found. However, shoulder dystocia can not be predicted accurately antepartum using routinely available clinical factors.

Birth Injuries↗

Membrane diffusing capacity and pulmonary capillary volume in rheumatoid disease.

In some patients with rheumatoid disease gas transfer across the lungs is abnormal. We measured the membrane component of gas transfer (Dm) and pulmonary capillary volume (Vc) in 48 patients with rheumatoid arthritis and in 48 normal volunteers matched for age, sex, and smoking habits. Volunteers had normal chest radiographs and normal forced expiratory volume in one second and vital capacity. There were no significant differences between the rheumatoid and control groups for Dm. Mean Vc in rheumatoid male smokers (64.0 ml, SD 16.5) was significantly lower than in control male smokers (76.3 ml, SD 18.0 p less than 0.05). In rheumatoid female smokers mean Vc (43.4 ml, SD 13.3) was significantly lower than in rheumatoid female non-smokers (58.4 ml, SD 15.4 p less than 0.01). There was no significant difference between rheumatoid and control female non-smokers (mean Vc 58.4 ml and 60.7 ml respectively). Significant differences in Vc in terms of per cent predicted normal were found between patients receiving corticosteroids and those not receiving corticosteroids or penicillamine (p less than 0.02) and between patients with nodules and those without (p less than 0.05). Patients with persistently low transfer factor for five years had a significantly lower Vc (p less than 0.02). There was no consistent correlation between Dm and Vc and dynamic compliance or static recoil pressure. It appears that the abnormality of transfer factor in rheumatoid disease previously demonstrated is caused by reduction of Vc. It seems that involvement of pulmonary blood vessels occurs in patients with nodules and is suppressed by treatment with corticosteroids.

Arthritis, Rheumatoid↗

Frequency dependence of dynamic compliance in patients with rheumatoid arthritis.

An investigation of lung function was carried out in 99 randomly selected patients with calssic or definite rheumatoid arthritis and in 60 control subjects matched for age, sex, and smoking habits. Mean FEV1 and mean VC were both significantly lower in the rheumatoid patients due to significant differences for women but mean FEV/VC ratio was 73.0% in the rheumatoid group and 72.1% in the control. Steady-state transfer factor was significantly greater in the normal men than in the comparable rheumatoid group, but there was no difference for women. After excluding patients with FEV1 less than 80% predicted normal and patients with low compliance, 72 rheumatoid patients and 45 controls provided series of tracings that could be assessed for a fall in Cdyn of 20% between 20 cycles and 60 cycles a minute. Dynamic compliance was not significantly different in any group at any rate of respiration. Fourteen of 72 rheumatoid patients and three of 45 controls showed frequency dependence (FDC). After the age of 50 the prevalence in the rheumatoid groupwas 11/38 and in the control group 2/27. This difference was significant (P less than 0.05). FDC was not consistently related to other abnormalities of lung function or to the duration, severity, or treatment of the rheumatoid arthritis. In various categories of smoking habits, dust exposure, or allergic tendency, the prevalence was always greater in the rheumatoid group. This provides evidence of patchy involvement of small airways, or alveoli and connective tissue, by the rheumatoid process.

Adolescent↗

Salmefamol and Salbutamol in exercise-induced asthma in children.

A double-blind controlled study is reported of salmefamol 200 mug and salbutamol 200 mug administered by aerosol before exercise tests in asthmatic children. Both drugs prevented exercise-induced asthma. There was no significant difference between them.

Adolescent↗

A sitting/companionship service for palliative care patients: Leicestershire, England.

Volunteers are vital to most UK hospices, performing wide-ranging duties. In our unit a carefully selected and trained group provides a professionally coordinated setting/companionship service for housebound patients. In this study we questioned their reasons for volunteering to "sit" and their evaluations of the training course. Six (of eight) completing the most recent course returned questionnaires. Five already were engaged in voluntary work, three within Leicestershire Hospice. They wanted to be "sitters" primarily to support the carers and to use their time constructively. They were aware of potential difficulties in "sitting" and considered the course had realistically acknowledged these and highlighted others that the volunteers had not contemplated, preparing them appropriately. Overall the course was valuable; all enthusiastically welcomed ongoing support and training.

Career Choice↗

Early pregnancy loss: how do men feel?

One in five pregnancies (20%) end in miscarriage. A specialized early pregnancy loss clinic to provide dedicated medical advice and support was established at the Rotunda Hospital in July 2002. A qualitative pilot study was conducted in July 2002 to assess the emotional response of male partners and also to establish if sufficient support services are provided for them. Ten consecutive couples attending the clinic 6-8 weeks following early pregnancy loss were included in the study. The partners were asked to complete a questionnaire with open and closed questions and return in the envelope provided. Nine questionnaires were returned. The average age of men attended was 28.6 years (range 20-39). The feelings described by men were typical of the grief and bereavement process. All wanted more time for discussion with doctors. They felt marginalized and although they felt support services for their partner were adequate, they felt that more support services for male partners should be provided. Based on these research findings, the specialized early pregnancy loss clinic is being developed to partner's needs and expectations. The appointment letter sent to the women now specifically states that the partner is welcome to attend. Partners are now included in the consultation.

Abortion, Spontaneous↗

Low cytomegalovirus sero-prevalence in Irish pregnant women.

The aim of this study was to determine the sero-prevalence of cytomegalovirus (CMV) IgG antibody in pregnant women in Ireland and assess individual risk factors for prior acquisition of CMV. In 2002, sera from 1047 pregnant women were tested by enzyme immunoassay for CMV IgG. Age and nationality were recorded for each patient. Among Irish-born women the following additional factors were also recorded: socio-economic status, number of children and occupational exposure to children. Only 30.4% (204/670) of Irish women were CMV antibody positive compared to 89.7% (322/359) of non-Irish women (p < 0.001). Non-Irish women were mostly from Sub-Saharan Africa, Eastern Europe and Asia. Lower socio-economic group and increasing number of children were significant independent predictors of CMV sero-positivity among Irish pregnant women (p < 0.05). Irish pregnant women have one of the lowest reported CMV sero-prevalence rates worldwide, indicating low circulation of CMV within the community. However, up to 70% of Irish women are susceptible to a primary infection during pregnancy.

Adult↗

Recurrent ovarian carcinoma: diagnosis and second-line therapy.

Approximately 10% of patients with ovarian cancer will develop a recurrence. Successful treatment of recurring disease has been documented, and recent developments in chemotherapy are encouraging. In our study, CA125 Tumour Marker was a useful marker to monitor the course of such disease, and detected recurring ovarian cancer at a sub-clinical level, leading to earlier diagnosis. This may have implications for outcome.

Adult↗

The National Maternity Hospital casualty department--a review.

This is a review of obstetrical and gynaecological patients presenting to our maternity unit after clinic hours from 1991 to 1993. Patient data was collected prospectively. The number of patients seen after clinic hours increased by 35%, from 2241 in 1991, to 3014 in 1993. Analysis of data from 1991 revealed that the majority of patients were self referred, General Practitioner referrals accounting for only 9% of patients seen. Antenatal patients were the largest group at 77%, 10% were postnatal and 13% had gynaecological complaints. Unbooked patients presenting with first trimester bleeding accounted for one third of all antenatal patients. Thirty eight percent of patients seen were admitted. The number of out-of-clinic hours patients constituted a sizeable proportion of our hospital population. We conclude that this service is a necessary and important part of patient care at a large maternity unit.

Emergency Service, Hospital↗

Prevention of ovarian cancer: a survey of the practice of prophylactic oophorectomy by consultant gynaecologists in Ireland.

The aim of this study was to investigate attitudes to prophylactic oophorectomy among practicing consultant gynaecologists in Ireland. An anonymous questionnaire was sent to 90 practicing consultants. A total of 68 replies were received (76%). Of these, the number who said they would remove apparently normal ovaries at the time of abdominal hysterectomy from premenopausal women in age groups < 35, 35-39, 40-44, 45-49 and > 49 years was 0 (0%), 0 (0%), 4 (6%), 29 (43%), and 46 (68%) respectively; and from postmenopausal women 60 (88%). Only 2 (3%) routinely considered oophorectomy when performing a vaginal hysterectomy. The majority of respondents said that (i) they would prescribe hormone replacement therapy in premenopausal oophorectomised women (98.5%); (ii) they did not consider unilateral oophorectomy to have a role in the prevention of ovarian cancer (84%); and (iii) they routinely discussed the question of prophylactic oophorectomy with their patients preoperatively (82%). Only 19 (27%) believed that the established figure of 10-15% of ovarian cancers could be prevented by oophorectomy at the time of hysterectomy for benign disease. 43 (63%) would perform prophylactic oophorectomy as a primary surgical procedure in women with a strong family history of ovarian carcinoma.

Adult↗