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Biomedical subjects

M Garvey

Publications and source records attributed to M Garvey.

At least 19 recordsLinked to original sources
PubMed1992

Radiographic screening at four months of infants at risk for congenital hip dislocation.

We report on a radiographic screening programme at four months of age for infants who were clinically normal at neonatal examination but were considered to be 'at risk' for congenital dislocation of the hip because of their family history, breech presentation, or a persistent click. From a total population of 13,662 live births over a two-year period, 357 (2.6%) infants at risk were identified. Of these 46 had abnormal radiographs (six subluxations, 40 acetabular dysplasia). In 12 infants treatment resulted in a normal hip; 34 required no treatment but were followed up until their radiographs were normal and walking had begun. Of the 311 infants with normal radiographs, 256 (82%) were examined after 15 months of age; none had any detectable abnormality. We suggest that radiography of the hip at four months is a valuable adjunct to neonatal screening for infants at increased risk of congenital dislocation of the hip.

Acetabulum↗
PubMed1991

Response of depression to very high plasma levels of imipramine plus desipramine.

Forty-five depressed patients were treated with imipramine for 6 weeks. Seven of 7 patients (100%) who had plasma levels of imipramine plus desipramine greater than 500 ng/ml showed a 50% or greater improvement in Hamilton depression scores compared with 23 of 38 patients (60%) with plasma levels less than 500 ng/ml (p less than 0.057).

Adult↗
PubMed1991

Is there a relationship between MHPG and anxiety in depressed patients?

Previous studies of the relationship between anxiety and 3-methoxy-4-hydroxyphenylglycol (MHPG) in depression have produced conflicting results. The possibility that different definitions of anxiety may have created these discrepant findings was explored. There was no convincing evidence that MHPG was associated with any of a wide range of different anxiety measurements that encompassed the anxiety concepts of somatic anxiety, psychic anxiety, agitation, or situational stress. The relationships of anxiety ratings to each other were also examined.

Anxiety Disorders↗
PubMed1991

Benzodiazepines for panic disorder. Are they safe?

The incidence of benzodiazepine dependence in properly selected patients with panic disorder appears to be very low. Patients with a history of drug abuse should not be given benzodiazepines. Physical dependence manifested by withdrawal symptoms occurs in 5% to 45% of patients who discontinue benzodiazepine therapy. Withdrawal symptoms are usually mild and attenuated by use of a tapering schedule of several weeks' duration. Physical dependence should not be confused with substance dependence, a disorder characterized by multiple problems in daily life caused by use of a particular substance.

Anti-Anxiety Agents↗
PubMed1991

Information and alternatives: the role of a youth non-governmental organization in drug abuse control.

The World Assembly of Youth (WAY), a non-governmental organization promoting the cultural and economic advancement of youth, includes in its programme activities the prevention of youth substance abuse and assistance to the large number of youth currently using drugs. Recognizing that the problem stems from the user, WAY works to provide information and alternatives leading to a responsible decision on the part of youth regarding their consumption.

Adolescent↗
PubMed1990

Comparison of panic disordered patients with high versus low MHPG.

Fourteen panic disorder patients with low 3-methoxy-4-hydroxyphenylglycol (MHPG) were compared to 14 patients with high MHPG. Patients with low MHPG were more likely during the preceding month to have experienced spontaneous panic attacks (P less than 0.008) than were patients with high MHPG. Patients with high MHPG had increased severity ratings on several individual symptoms of anxiety.

Adult↗
PubMed1990

Elevated levels of N-acetyl-beta-glucosaminidase in affective disorders and chemical dependence.

Levels of N-acetyl-beta-glucosaminidase (NAG) were examined in 575 patients with various psychiatric diagnoses and 38 non-ill controls. Ten percent of affectively disordered patients and 19% of chemically dependent patients had abnormal NAG levels, whereas none of the 38 controls did (P less than 0.05 and P less than 0.003 respectively). Other psychiatric diagnostic groups were not associated with abnormal levels of this enzyme.

Acetylglucosaminidase↗
PubMed1990

Reduction of gastrointestinal symptoms following treatment for panic disorder.

Symptoms of gastrointestinal distress, including those of irritable bowel syndrome, were reported more frequently by patients with panic disorder than by nonanxious controls. Five of 30 subjects with panic disorder met criteria for irritable bowel syndrome, the onset of which coincided with the onset of panic disorder. Effective treatment for the anxiety disorder was accompanied by a reduction in gastrointestinal symptoms in all subjects.

Adult↗
PubMed1989

Lymphopenia in primary degenerative dementia.

The central nervous and immune systems share a number of common properties, e.g. neurotransmitter receptors. In contrast to age matched healthy and/or hypertensive controls, the total lymphocyte count in 25 carefully diagnosed and staged patients with primary degenerative dementia were significantly reduced and also correlated with the severity of their dementia. Subjects' age, age of dementia onset, or duration of illness were unrelated. Total leukocyte counts were similar between groups. Nutritional status, ACTH, or plasma cortisol in dementia cohort were also not explanatory of their lymphopenia. These results are potentially significant in light of an immune hypothesis for primary degenerative dementia: Alzheimer's type and/or that population's high concomitant risk of infection.

Adrenocorticotropic Hormone↗
PubMed1989

The relationship of panic disorder and its treatment outcome to 24-hour urinary MHPG levels.

Levels of 24-hour urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) were not markedly elevated in a group of 35 panic disorder patients when compared to healthy controls (mean = 2,430 micrograms/day vs. 2,130 micrograms/day). There was a weak association between elevated pretreatment levels of MHPG and a positive treatment response to alprazolam or diazepam. Alprazolam and diazepam may differ in their effects on MHPG.

Adolescent↗
PubMed1988

Use of psychiatric referral by family physicians.

The family physician occupies a critical place in the detection and management of mental health problems. Optimal case management requires an awareness of individual limitations and effective use of a psychiatric consultant. The consultant must understand the unique relationship between the patient and the family physician. Several historical biases may impede the physician's use of psychiatric consultation and the patient's acceptance of psychiatric treatment options.

Humans↗