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Biomedical subjects

M Garrido Peralta

Publications and source records attributed to M Garrido Peralta.

At least 19 recordsLinked to original sources
PubMed1990

[Changes in the glycolytic pathway in patients with essential arterial hypertension].

The defect of the sodium pump of the blood cell membrane in patients with essential blood hypertension, can induce changes in the metabolic use of ATP, especially at glucolytic pathway level. We studied the blood levels of ATP (32.51 +/- 10.80 mg/100 ml), 2,3-DPG (0.82 +/- 0.47 mumol/ml), piruvate (0.36 +/- 0.16 mg/100 ml) and lactate (18.88 +/- 4.53 mg/dl), of a group of 50 patients with essential blood hypertension and of 50 healthy persons in the control group (17.09 +/- 6.37 mg/100 ml, 0.45 +/- 0.23 mumol/ml, 0.33 +/- 0.15 mg/100 ml and 17.32 +/- 3.85 mg/dl respectively). There were statistically significant differences between ATP (p less than 0.0005) levels and 2,3-DPG and lactate (p less than 0.05). These results force us to study the presence of those changes on peripheral tissues to see whether they play an important role in hypertension complications, especially in respect of the vascular wall.

2,3-Diphosphoglycerate↗
PubMed1990

[The role of prostacyclin and thromboxane in the antihypertensive action of enalapril].

Enalapril produces an inhibition of the angiotensin-renin system, correlating the pre-therapy plasmatic renin activity with blood pressure decrease, during its administration. This does not always happen, data to the contrary existing in literature, suggesting that there are some other acting mechanisms. We studied 34 hypertensive patients, whose blood pressure levels were controlled by Enalapril at a mean dosage of 12.32 +/- 0.9. Determining plasmatic concentration of 6-keto PGF1a (a prostacyclin metabolite), T x B2 (a thromboxane A2 metabolite), their distribution, plasmatic renin activity and a radiological and biochemical study. We found a significant increase in their distribution and plasmatic renin at the end of the essay. The results suggest a possible double active mechanism: angiotension-renin and prostaglandins systems, owing to the imbalance occurring between prostacyclin and thromboxane, the first named being the most favoured. This, together with easy application and the lack of side effects, made this drug useful for treatment of blood hypertension.

Adolescent↗
PubMed1990

[Intestinal calcium and vitamin D absorption in essential arterial hypertension].

The intestinal absorption of calcium and seric levels of calcifediol and calcitriol were studied in 27 patients with essential blood hypertension (BH) and 20 normal patients in a control group. The hypertensive patients were divided in three groups depending on the plasmatic renin activity (PRA), (high, normal, low). We found a significantly higher rate of intestinal calcium absorption in the group of patients with BH and low PRA than in the control group (22.73 +/- 19.05 and 10.7 +/- 17.13% respectively) (p less than 0.025). The seric levels of calcitriol (1,25 (OH) 2D3) were significantly higher in the group of patients with hypertension and low PRA than in the control group (48.16 +/- 5.25 and 33.13 +/- 2.9 pg/ml respectively) (p less than 0.025). The seric levels of calcifediol (25-OH-D3) were significantly lower in low PRA patients than those patients in the control group (12.37 +/- 2.44 and 21.94 +/- 2.82 ng/ml respectively) (p less than 0.025). We concluded that patients with essential blood hypertension and low PRA have significantly lower calcitriol levels than any other group, probably conditioning the greater intestinal calcium absorption shown in this group.

Calcifediol↗
PubMed1990

[Intraerythrocyte levels of glucose-6-phosphate dehydrogenase in patients with essential arterial hypertension and persons with normal blood pressure. Modifications after nifedipine therapy].

We evaluate the levels of intra-erythrocytes glucose-6-phosphate-dehydrogenase (G6PD) in a group of 50 patients with essential blood hypertension (EBH) (214.76 +/- 38.31 mU/ml) and in a group of 50 healthy persons (130.11 +/- 49.50 mU/ml) (p minor of 0.0005). At the same time, we have analysed the intraerythrocyte levels of G6PD of 34 healthy sons and daughters of hypertensive parents, detecting high levels in 13 of them. We observed a significant decrease of G6PD after the therapy with nifedipine in 20 hypertensive patients (p less than 0.0005). We conclude that measurement of G6PD enzyme activity can prove to be a good marker of essential hypertension. This change occurs at an early stage and is noticeable in high risk persons with family predisposition. It is possible to modify levels by working on cation changes through membrane cells by calcium-antagonist.

Adult↗
PubMed1990

[Ileocecal and lymph node tuberculosis: a rare association in our area].

A case of ileocecal tuberculosis associated to lymphatic nodes TB, is presented. This association is not frequently observed in all series and isolated cases registered in medical literature. In this particular case, we comment on the pathogenic problems of primary intestinal TB and the importance of the systemic clinical suspicion to diagnose this, nowadays, rare problem in our area. Finally, we discuss the value of certain diagnosis criteria related to the actual therapy, in which the conservative character is dominant, this therapy also being applied to post-surgical fistula in some individual cases such as the one presented here.

Female↗
PubMed1989

[Rhabdomyolysis, ventricular fibrillation and respiratory insufficiency as a form of presentation of type-I renal tubular acidosis].

The renal tubular acidosis type 1 might be laboratory findings or a group of muscular symptoms, renal complication or delayed growth. It can also be a non-frequent case of rhabdomyolysis, producing serious cardiac and respiratory complications such as those described in this case. This tubular disease can produce alteration of calcium and ionic metabolism, and stimulation of renin-angiotensin-aldosterone axis, both reversible with the correction of the systemic pH with alcalin.

Acidosis, Renal Tubular↗
PubMed1989

[Effect of an oral calcium supplement in the treatment of slight-to- moderate essential arterial hypertension].

51 patients with mild essential hypertension (EH) were randomly divided into two groups; the first group (31 patients) was treated with 1 g. of oral calcium during a period of 8 weeks; the second group received a placebo. The treated with calcium showed a significant decrease in blood pressure (BP), the maximal reduction being of 6 mm Hg in the systolic pressure (SBP) and 3 mm in the diastolic (DBP) at the end of the 8th week. We found a substantial positive relationship between the decrease in SBP and seric renin activity (p less than 0.05), as well as a significant negative relationship (p less than 0.05) between DBP and the seric level of parathyroid hormone (PTH). During the administration of the oral calcium supplement, the BP decreased in an inverse proportion to the plasmatic renin and seric level of PTH.

Administration, Oral↗
PubMed1989

[Neutrophil chemotaxis in patients with chronic active hepatitis].

The serum of 18 patients diagnosed as having chronic active hepatitis (CAH) was studied in order to ascertain the neutrophil motility in healthy person serum. The chemotaxis and the chemokinesis induced by the serum of the patients were lower than those obtained using a control serum. When the control serum, activated by zymosan, was added to the patients serum a decrease of chemotaxis was observed. Contrary to this, when activated serum of patients was added to the control serum, there was no alteration of chemotaxis. We concluded that serum of patients affected by CAH have an inhibitor of the motility of neutrophils.

Adult↗