Value of splenic aspirate in the diagnosis of hairy cell leukaemia.
We present a case with hairy cell leukaemia which was diagnosed on a splenic aspirate. The patient refused splenectomy.
Biomedical subjects
Publications and source records attributed to M Gaiha.
We present a case with hairy cell leukaemia which was diagnosed on a splenic aspirate. The patient refused splenectomy.
Seventy cases of malignant lymphoma studied for bone marrow involvement by Jamshidi needle trephine biopsy are reported. Bone marrow involvement was detected in 27 cases. Bone marrow biopsy helped the advancement of disease to stage IV in 22 cases though they were in stage I-III initially. Jamshidi needle biopsy was found to be a very useful diagnostic tool for detection of lymphoma deposit in the marrow.
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The present study was carried out in 33 cases of cyanotic congenital heart disease (CCHD) to determine the prevalence of iron deficiency anemia (IDA) and its correlation to hyperviscosity symptoms in terms of hematocrit levels. Furthermore, the study was aimed at assessing the response to low dose iron therapy (60 mg of elemental iron once daily) in relieving symptoms of hyperviscosity. All these cases were evaluated for presence of symptoms of hyperviscosity and later subjected to various hematological & biochemical parameters of iron deficiency anemia including hemoglobin (Hb), pack cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), serum iron, total iron binding capacity respectively. Results showed presence of IDA in 6/33 cases (18.2%) and hyperviscosity symptoms in 10/33 cases (30.3%). Amongst the group with symptoms of hyperviscosity, in the subset having IDA these symptoms were observed at PCV levels of 0.52 L/L to 0.58 L/L in contrast to the subset not deficient in iron where the symptoms occurred at a PCV 0.68 L/L. Relief of symptoms of hyperviscosity was evident with a minimal rise of mean hemoglobin by 2.1 gm/dl. It was concluded that IDA was not an uncommon finding in CCHD cases and that it leads to symptoms of hyperviscosity at a level of PCV much lower than those known to produce these symptoms. Finally low dose iron therapy was found effective in relieving the symptoms of hyperviscosity.